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Chemical Compound Review:

Preforan 2-nitro-1-(4-nitrophenoxy)- 4...

Synonyms: Fluordifen, Fluorodifen, Soyex, Fluorodifene, Fluorodiphen, ...

Dixon, D.P. et al., Dixon, D.P. et al., Nimptsch, J. et al.

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High impact information on Fluorodiphen

Further mutagenesis of this residue generated an EFD with a 29-fold higher catalytic efficiency toward fluorodifen as compared with the parents but with unaltered catalysis toward other substrates [1].
The glutathione transferases (GSTs) from maize (Zea mays L.) with activities toward the chloroacetanilide herbicide metolachlor and the diphenyl ether herbicide fluorodifen were fractionated into two pools based on binding to affinity columns [2].
Myriophyllum quitense reacts to the pollution stress increasing the activity of glutathione-S-transferases (CDNB and Fluorodifen), glutathione reductase (GR) and peroxidase (POD) [3].

Analytical, diagnostic and therapeutic context of Fluorodiphen

Using reconstructive PCR, a series of mutant GSTUs were generated from in vitro recombination and mutagenesis of the maize sequences ZmGSTU1 and ZmGSTU2 (with the prefix Zm designating Zea mays L.). A screen of 5000 mutant GSTUs identified seven enzymes with enhanced fluorodifen detoxifying activity [1].

References

Forced evolution of a herbicide detoxifying glutathione transferase. Dixon, D.P., McEwen, A.G., Lapthorn, A.J., Edwards, R. J. Biol. Chem. (2003) [Pubmed]
Purification, regulation and cloning of a glutathione transferase (GST) from maize resembling the auxin-inducible type-III GSTs. Dixon, D.P., Cole, D.J., Edwards, R. Plant Mol. Biol. (1998) [Pubmed]
Antioxidant and biotransformation enzymes in Myriophyllum quitense as biomarkers of heavy metal exposure and eutrophication in Suquía River basin (Córdoba, Argentina). Nimptsch, J., Wunderlin, D.A., Dollan, A., Pflugmacher, S. Chemosphere (2005) [Pubmed]

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