The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Enzyme Induction

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Enzyme Induction


Psychiatry related information on Enzyme Induction


High impact information on Enzyme Induction


Chemical compound and disease context of Enzyme Induction


Biological context of Enzyme Induction


Anatomical context of Enzyme Induction


Associations of Enzyme Induction with chemical compounds


Gene context of Enzyme Induction

  • These results indicate that in uninduced mice, the normal Ah receptor facilitates formation of IQ/DNA adducts in liver and alters the profile of adducts in lung, via an unknown mechanism, whereas the Ah receptor-dependent enzyme induction reduces adducts in liver, probably due to increased detoxification, but increases them in lung [31].
  • METHODS: We measured hepatic CYP3A activity at baseline and after rifampin (INN, rifampicin) enzyme induction in 12 patients with end-stage renal disease and 12 healthy, age-matched controls [4].
  • We compared the performance of several modifications of the caffeine test for measurement of CYP1A2 activity in subjects with exceptionally high, low, or absent enzyme induction [32].
  • CONCLUSIONS: Alterations in the activity of CYP3A4, CYP2C9 and FMO3 through genetic polymorphisms, enzyme induction or inhibition bear the potential to cause clinically significant changes in perazine clearance [33].
  • However, associated with IL-1beta, TNF-alpha greatly potentiated this enzyme induction [34].

Analytical, diagnostic and therapeutic context of Enzyme Induction


  1. Coronary heart disease, cancer, lipoproteins, and the effects of clofibrate: is enzyme induction a common link and are lipoproteins red herrings? Heller, R.F. Lancet (1981) [Pubmed]
  2. Leiomyoblastoma associated with intractable hypercalcemia and elevated 1,25-dihydroxycholecalciferol levels. Treatment by hepatic enzyme induction. Maislos, M., Sobel, R., Shany, S. Arch. Intern. Med. (1985) [Pubmed]
  3. Increased faecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment. Tsai, H.H., Dwarakanath, A.D., Hart, C.A., Milton, J.D., Rhodes, J.M. Gut (1995) [Pubmed]
  4. Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. Dowling, T.C., Briglia, A.E., Fink, J.C., Hanes, D.S., Light, P.D., Stackiewicz, L., Karyekar, C.S., Eddington, N.D., Weir, M.R., Henrich, W.L. Clin. Pharmacol. Ther. (2003) [Pubmed]
  5. Changes in serum enzymes in moderate drinkers after an alcohol challenge. Nemesánszky, E., Lott, J.A., Arato, M. Clin. Chem. (1988) [Pubmed]
  6. Hepatic gamma-glutamyltransferase activity in alcoholic fatty liver: comparison with other liver enzymes in man and rats. Teschke, R., Neuefeind, M., Nishimura, M., Strohmeyer, G. Gut (1983) [Pubmed]
  7. Long-term nitrazepam treatment in psychiatric out-patients with insomnia. Kangas, L., Kanto, J., Lehtinen, V., Salminen, J. Psychopharmacology (Berl.) (1979) [Pubmed]
  8. Hormonal regulation of plasminogen activator mRNA production in porcine kidney cells. Nagamine, Y., Sudol, M., Reich, E. Cell (1983) [Pubmed]
  9. Microsomal enzyme induction by methadone and its implications on tolerance to methodone lethality. Masten, L.W., Peterson, G.R., Burkhalter, A., Way, E.L. Nature (1975) [Pubmed]
  10. Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Insel, P.A., Bourne, H.R., Coffino, P., Tomkins, G.M. Science (1975) [Pubmed]
  11. Induction of cytochrome P4501A1. Whitlock, J.P. Annu. Rev. Pharmacol. Toxicol. (1999) [Pubmed]
  12. Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis. Xu, G., Salen, G., Shefer, S., Tint, G.S., Nguyen, L.B., Chen, T.S., Greenblatt, D. J. Clin. Invest. (1999) [Pubmed]
  13. The influence of culture conditions on the induction of tyrosine aminotransferase by cyclic nucleotides in rat hepatoma cells. Stellwagen, R.H., Kohli, K.K., Sailor, R.D. J. Cell. Physiol. (1977) [Pubmed]
  14. Bezafibrate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hyperlipidaemia. Monk, J.P., Todd, P.A. Drugs (1987) [Pubmed]
  15. beta-Lactamase stability and in vitro activity of oral cephalosporins against strains possessing well-characterized mechanisms of resistance. Sanders, C.C. Antimicrob. Agents Chemother. (1989) [Pubmed]
  16. Guinea-pig model of halothane-associated hepatotoxicity in the absence of enzyme induction and hypoxia. Lunam, C.A., Cousins, M.J., Hall, P.D. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  17. Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells. Shertzer, H.G., Vasiliou, V., Liu, R.M., Tabor, M.W., Nebert, D.W. Chem. Res. Toxicol. (1995) [Pubmed]
  18. Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain. Brdar, B. Cancer Res. (1986) [Pubmed]
  19. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Chen, Y., Kramer, D.L., Diegelman, P., Vujcic, S., Porter, C.W. Cancer Res. (2001) [Pubmed]
  20. Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP. A role for the rapid form of histone acetylation. Plesko, M.M., Hargrove, J.L., Granner, D.K., Chalkley, R. J. Biol. Chem. (1983) [Pubmed]
  21. Drug interactions affecting analgesic toxicity. Prescott, L.F., Critchley, J.A. Am. J. Med. (1983) [Pubmed]
  22. Enzyme induction in the elderly: effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone. Dilger, K., Hofmann, U., Klotz, U. Clin. Pharmacol. Ther. (2000) [Pubmed]
  23. Induction of calcium-dependent nitric oxide synthases by sex hormones. Weiner, C.P., Lizasoain, I., Baylis, S.A., Knowles, R.G., Charles, I.G., Moncada, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  24. P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats. Diwan, B.A., Rice, J.M., Nims, R.W., Lubet, R.A., Hu, H., Ward, J.M. Cancer Res. (1988) [Pubmed]
  25. Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N'-nitrosonornicotine in F344 rats. Castonguay, A., Rivenson, A., Trushin, N., Reinhardt, J., Spathopoulos, S., Weiss, C.J., Reiss, B., Hecht, S.S. Cancer Res. (1984) [Pubmed]
  26. Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells. Sardana, M.K., Sassa, S., Kappas, A. J. Biol. Chem. (1982) [Pubmed]
  27. Regulation of creatine phosphokinase expression during differentiation of BC3H1 cells. Olson, E.N., Caldwell, K.L., Gordon, J.I., Glaser, L. J. Biol. Chem. (1983) [Pubmed]
  28. Evidence for multiple sites of regulation of heme synthesis in murine erythroleukemia cells. Ebert, P.S., Bonkowsky, H.L., Deisseroth, A. J. Natl. Cancer Inst. (1979) [Pubmed]
  29. Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs. McClements, B.M., Hyland, M., Callender, M.E., Blair, T.L. Lancet (1990) [Pubmed]
  30. Enzyme inducation as a possible cause of increased serum-trigylcerides after oral contraceptives. Martin, J.V., Martin, P.J., Goldberg, D.M. Lancet (1976) [Pubmed]
  31. Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction. Nerurkar, P.V., Schut, H.A., Anderson, L.M., Riggs, C.W., Fornwald, L.W., Davis, C.D., Snyderwine, E.G., Thorgeirsson, S.S., Weber, W.W., Rice, J.M., Levy, G.N. Mol. Pharmacol. (1996) [Pubmed]
  32. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Abraham, K., Geusau, A., Tosun, Y., Helge, H., Bauer, S., Brockmöller, J. Clin. Pharmacol. Ther. (2002) [Pubmed]
  33. Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Störmer, E., Brockmöller, J., Roots, I., Schmider, J. Psychopharmacology (Berl.) (2000) [Pubmed]
  34. TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways. Said, F.A., Werts, C., Elalamy, I., Couetil, J.P., Jacquemin, C., Hatmi, M. Br. J. Pharmacol. (2002) [Pubmed]
  35. Measurement of angiotensin converting enzyme induction and inhibition using quantitative in vitro autoradiography: tissue selective induction after chronic lisinopril treatment. Kohzuki, M., Johnston, C.I., Chai, S.Y., Jackson, B., Perich, R., Paxton, D., Mendelsohn, F.A. J. Hypertens. (1991) [Pubmed]
  36. Effects of testosterone, hypophysectomy and growth hormone treatment on clofibrate induction of peroxisomal beta-oxidation in female rat liver. Sugiyama, H., Yamada, J., Suga, T. Biochem. Pharmacol. (1994) [Pubmed]
  37. Effects of ageing on transcriptional and post-transcriptional regulation of malic enzyme and glucose-6-phosphate dehydrogenase in rat liver. Fukuda, H., Katsurada, A., Iritani, N. Eur. J. Biochem. (1990) [Pubmed]
  38. Disopyramide pharmacokinetics and metabolism: effect of inducers. Kapil, R.P., Axelson, J.E., Mansfield, I.L., Edwards, D.J., McErlane, B., Mason, M.A., Lalka, D., Kerr, C.R. British journal of clinical pharmacology. (1987) [Pubmed]
  39. m-xylene toxicokinetics in phenobarbital-treated rats: comparison among inhalation exposure, oral administration, and intraperitoneal administration. Kaneko, T., Wang, P.Y., Tsukada, H., Sato, A. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
WikiGenes - Universities