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Chemical Compound Review

Lomeguatrib     6-[(4-bromothiophen-2- yl)methoxy]-7H-purin...

Synonyms: PaTrin-2, PaTrin 2, QCR-156, CHEMBL339133, SureCN4621691, ...
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Disease relevance of Lomeguatrib


High impact information on Lomeguatrib


Chemical compound and disease context of Lomeguatrib


Analytical, diagnostic and therapeutic context of Lomeguatrib


  1. Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Ranson, M., Middleton, M.R., Bridgewater, J., Lee, S.M., Dawson, M., Jowle, D., Halbert, G., Waller, S., McGrath, H., Gumbrell, L., McElhinney, R.S., Donnelly, D., McMurry, T.B., Margison, G.P. Clin. Cancer Res. (2006) [Pubmed]
  2. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Clemons, M., Kelly, J., Watson, A.J., Howell, A., McElhinney, R.S., McMurry, T.B., Margison, G.P. Br. J. Cancer (2005) [Pubmed]
  3. Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Watson, A.J., Sabharwal, A., Thorncroft, M., McGown, G., Kerr, R., Bojanic, S., Soonawalla, Z., King, A., Miller, A., Waller, S., Leung, H., Margison, G.P., Middleton, M.R. Clin. Cancer Res. (2010) [Pubmed]
  4. Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Barvaux, V.A., Lorigan, P., Ranson, M., Gillum, A.M., McElhinney, R.S., McMurry, T.B., Margison, G.P. Mol. Cancer Ther. (2004) [Pubmed]
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