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Chemical Compound Review

ANAPP3     [[[(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: AC1MI2US, 58775-41-0, 80832-84-4, Arylazido aminopropionyl ATP, Arylazidoaminopropyladenosine triphosphate
 
 
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High impact information on Arylazido aminopropionyl ATP

  • The effects of the ATP affinity label periodate-oxidized ATP (ATP-2',3'-dialdehyde; P-ATP) on contractile responses of the guinea pig vas deferens to ATP was characterized and compared to the effects of the specific P2x-purinoceptor photoaffinity label antagonist, arylazido aminopropionyl ATP (ANAPP3) [1].
  • To characterize the site of covalent photoincorporation of ANAPP3, intact vasa deferentia were treated with [3H]ANAPP3 and samples of homogenate, cytosol and a crude membrane fraction were analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) [2].
  • In order to determine if ATP contributes as an excitatory transmitter in the guinea-pig bladder, experiments were conducted with ANAPP3, a photoaffinity analogue of ATP, which is an antagonist of adenine nucleotides in several other smooth muscles [3].
  • The specific purine-receptor antagonist, arylazido aminopropionyl ATP (ANAPP3), was used to determine if purines released from nerves of the guinea-pig was deferens contribute to the neurogenic response [4].
 

Anatomical context of Arylazido aminopropionyl ATP

 

Associations of Arylazido aminopropionyl ATP with other chemical compounds

  • The photoincorporation of [3H]ANAPP3 was associated with the crude membrane fraction and not the cytosol, was reduced in the presence of ATP in an ATP-concentration-dependent manner, was lessened following pretreatment of the tissues with photolyzed nonradiolabeled ANAPP3, and was unaffected by the nucleoside transport inhibitor, dipyridamole [2].
  • It has been demonstrated previously with the vas deferens of the guinea-pig that the first and second phases of the contractile response to motor nerve stimulation are preferentially antagonized by the P2-purinoceptor antagonist arylazido aminopropionyl ATP (ANAPP3), and the alpha 1-adrenoceptor antagonist prazosin, respectively [6].
 

Analytical, diagnostic and therapeutic context of Arylazido aminopropionyl ATP

References

  1. Two dissociable phases in the contractile response of the guinea pig isolated vas deferens to adenosine triphosphate. Fedan, J.S., Lamport, S.J. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  2. Interaction of [3H]arylazido aminopropionyl ATP ([3H]ANAPP3) with P2-purinergic receptors in the smooth muscle of the isolated guinea-pig vas deferens. Fedan, J.S., Hogaboom, G.K., O'Donnell, J.P., Jeng, S.J., Guillory, R.J. Eur. J. Pharmacol. (1985) [Pubmed]
  3. Evidence for a contribution by purines to the neurogenic response of the guinea-pig urinary bladder. Westfall, D.P., Fedan, J.S., Colby, J., Hogaboom, G.K., O'Donnell, J.P. Eur. J. Pharmacol. (1983) [Pubmed]
  4. Contribution by purines to the neurogenic response of the vas deferens of the guinea pig. Fedan, J.S., Hogaboom, G.K., O'Donnell, J.P., Colby, J., Westfall, D.P. Eur. J. Pharmacol. (1981) [Pubmed]
  5. Comparison of the effects of arylazido aminopropionyl ATP (ANAPP3), an ATP antagonist, on responses of the smooth muscle of the guinea-pig vas deferens to ATP and related nucleotides. Fedan, J.S., Hogaboom, G.K., Westfall, D.P., O'Donnell, J.P. Eur. J. Pharmacol. (1982) [Pubmed]
  6. A pharmacological investigation of the biphasic nature of the contractile response of rabbit and rat vas deferens to field stimulation. Sneddon, P., Westfall, D.P., Colby, J., Fedan, J.S. Life Sci. (1984) [Pubmed]
  7. Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label. Theobald, R.J., Hoffman, V. Life Sci. (1986) [Pubmed]
 
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