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Chemical Compound Review:

AC1L1F2Q [2-(17-acetyloxy-6,9- difluoro-11-hydroxy...

Synonyms:

Johansson, E.A. et al., Krueger, G.G. et al., Bäumer, W. et al., Bluefarb, S.M. et al., Hersle, K. et al.

Bäumer, Seegers, Braun, Tschernig, Kietzmann,

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Disease relevance of Diflorasone diacetate

OBJECTIVE: Our purpose was to determine the relative efficacy of flurandrenolide (4 microg/cm2) tape versus 0.05% diflorasone diacetate ointment in plaque psoriasis [1].
RESULTS: Flurandrenolide tape-treated plaques showed consistently greater clearing in terms of erythema, scaling, induration, and treatment success for all plaques, as well as the subset of knee and elbow plaques, when compared with the lesions receiving diflorasone diacetate ointment [1].
TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines [2].
At Week 3, this difference in the improvement of pruritus was marginally significant in favour of diflorasone diacetate [3].
Excluding the complications due to a secondary infection, no adverse reactions were recorded in the diflorasone diacetate-treated patients; 1 betamethasone valerate-treated patient developed telangiectasia [3].

High impact information on Diflorasone diacetate

The effects on chemokine concentrations of the highly selective phosphodiesterase 4 inhibitor cilomilast and the glucocorticoid diflorasone diacetate were studied in mouse ears [2].
Once daily application of diflorasone diacetate ointment compared with betamethasone valerate ointment twice daily in patients with eczematous dermatoses [4].
In a double-blind comparison in 384 patients with dermatoses, 0-05% diflorasone diacetate cream was as effective as 0-05% fluocinonide cream in the therapy of lesions of psoriasis or atopic/neurodermatitis [5].

Chemical compound and disease context of Diflorasone diacetate

At Week 2, the diflorasone diacetate group improved significantly more than the betamethasone valerate group with respect to pruritus [3].

References

Comparative efficacy of once-daily flurandrenolide tape versus twice-daily diflorasone diacetate ointment in the treatment of psoriasis. Krueger, G.G., O'Reilly, M.A., Weidner, M., Dromgoole, S.H., Killey, F.P. J. Am. Acad. Dermatol. (1998) [Pubmed]
TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Bäumer, W., Seegers, U., Braun, M., Tschernig, T., Kietzmann, M. Br. J. Dermatol. (2004) [Pubmed]
Comparative efficacy of once a day diflorasone diacetate and twice a day betamethasone valerate ointment applications in eczematous dermatitis. Johansson, E.A., Stiger, T.R. Current medical research and opinion. (1984) [Pubmed]
Once daily application of diflorasone diacetate ointment compared with betamethasone valerate ointment twice daily in patients with eczematous dermatoses. Hersle, K., Mobacken, H. J. Int. Med. Res. (1982) [Pubmed]
Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. Bluefarb, S.M., Howard, F.M., Leibsohn, E., Schlagel, C.A., Wexler, L. J. Int. Med. Res. (1976) [Pubmed]

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