The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ccl27a  -  chemokine (C-C motif) ligand 27A

Mus musculus

Synonyms: ALP, AW558992, C-C motif chemokine 27, CC chemokine ILC, CTACK, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ccl27


High impact information on Ccl27


Chemical compound and disease context of Ccl27


Biological context of Ccl27

  • Chemotaxis transmigration assay demonstrated that CCL27 promotes a greater degree of migration of T cells in diseased Tg mice [2].
  • Because differences in ALP activity, bone-forming ability, cortical bone width, and osteoblastic activity were detected at birth, the different MAR/BFR phenotypes develop at very early life and even perhaps during embryogenesis [9].
  • These data show that VIP, without affecting cell proliferation, can stimulate osteoblastic ALP biosynthesis and bone noduli formation by a mechanism mediated by cyclic AMP [10].
  • Forskolin and choleratoxin stimulated ALP activity and cyclic AMP formation in a concentration-dependent manner, without affecting cell number [10].

Anatomical context of Ccl27

  • Finally, CTACK selectively attracts CLA(+) memory T cells [11].
  • CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes [11].
  • Specifically, CTACK message is found in the mouse epidermis and in human keratinocytes, and anti-CTACK mAbs predominantly stain the epithelium [11].
  • To examine biological roles for PESKY we have overexpressed it in 3T3 cells [12].
  • Using the murine embryonal stem cell system, we have identified a novel gene encoding a highly divergent member of the beta-chemokine family of proinflammatory mediators and have called this protein ESkine [13].

Associations of Ccl27 with chemical compounds

  • Moreover, mutation of the tyrosines at the amino terminus of PSGL-1 to phenylalanine abolished the binding, further supporting the role of sulfated tyrosines in the CCL27-PSGL-1 interaction [14].
  • In contrast, PTH/dexamethasone-treated cells formed Alcian blue-positive nodules but remained negative for alizarin red staining and ALP activity [15].
  • BMP-2/insulin-treated cells became refractile without forming cartilaginous nodules and reached terminal differentiation, became positive for alizarin red staining, and developed considerable ALP activity [15].
  • The highly proliferating bone marrow cells were negative for ALP and OCN, suggesting that they could represent early osteoblast precursors [16].
  • The cyclic AMP phosphodiesterase inhibitors ZK 62 711 (10(-4) M) and isobutyl-methylxanthine (10(-4) M) stimulated ALP activity and synergistically potentiated the effect of VIP [10].

Other interactions of Ccl27


Analytical, diagnostic and therapeutic context of Ccl27

  • Both human and mouse CTACK are detected only in skin by Southern and Northern blot analyses [11].
  • In the present study, we investigated the role of CCL27, a T cell skin-homing chemokine known to be elevated in sera of human AD patients, in disease development in our animal model of AD [2].
  • CCL27 transcripts are most abundantly expressed in the retina, as judged by in situ hybridization [18].
  • METHODS: Conventional RT-PCR, 5' RACE, and dideoxy DNA sequencing were used to examine the sequences of CCL27 related RNAs in the eye [18].
  • During the 8 days following viral infection we have compared ALP activity in serum and liver homogenates with ALP cytological localization in liver tissue (light and electron microscopy) [19].


  1. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki, I., Kitaura, M., Baba, M., Nakayama, T., Izawa, D., Imai, T., Yamada, H., Hieshima, K., Suzuki, R., Nomiyama, H., Yoshie, O. FEBS Lett. (1999) [Pubmed]
  2. CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model. Chen, L., Lin, S.X., Agha-Majzoub, R., Overbergh, L., Mathieu, C., Chan, L.S. Int. Immunol. (2006) [Pubmed]
  3. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. Murakami, T., Cardones, A.R., Finkelstein, S.E., Restifo, N.P., Klaunberg, B.A., Nestle, F.O., Castillo, S.S., Dennis, P.A., Hwang, S.T. J. Exp. Med. (2003) [Pubmed]
  4. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. Reiss, Y., Proudfoot, A.E., Power, C.A., Campbell, J.J., Butcher, E.C. J. Exp. Med. (2001) [Pubmed]
  5. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Gao, J.Q., Tsuda, Y., Katayama, K., Nakayama, T., Hatanaka, Y., Tani, Y., Mizuguchi, H., Hayakawa, T., Yoshie, O., Tsutsumi, Y., Mayumi, T., Nakagawa, S. Cancer Res. (2003) [Pubmed]
  6. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey, B., Alenius, H., Müller, A., Soto, H., Bowman, E.P., Yuan, W., McEvoy, L., Lauerma, A.I., Assmann, T., Bünemann, E., Lehto, M., Wolff, H., Yen, D., Marxhausen, H., To, W., Sedgwick, J., Ruzicka, T., Lehmann, P., Zlotnik, A. Nat. Med. (2002) [Pubmed]
  7. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Bäumer, W., Seegers, U., Braun, M., Tschernig, T., Kietzmann, M. Br. J. Dermatol. (2004) [Pubmed]
  8. Carcinogenicity of biphenyl in mice by two years feeding. Umeda, Y., Aiso, S., Yamazaki, K., Ohnishi, M., Arito, H., Nagano, K., Yamamoto, S., Matsushima, T. J. Vet. Med. Sci. (2005) [Pubmed]
  9. In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells. Sheng, M.H., Lau, K.H., Beamer, W.G., Baylink, D.J., Wergedal, J.E. Bone (2004) [Pubmed]
  10. Neuro-hormonal control of bone metabolism: vasoactive intestinal peptide stimulates alkaline phosphatase activity and mRNA expression in mouse calvarial osteoblasts as well as calcium accumulation mineralized bone nodules. Lundberg, P., Boström, I., Mukohyama, H., Bjurholm, A., Smans, K., Lerner, U.H. Regul. Pept. (1999) [Pubmed]
  11. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Morales, J., Homey, B., Vicari, A.P., Hudak, S., Oldham, E., Hedrick, J., Orozco, R., Copeland, N.G., Jenkins, N.A., McEvoy, L.M., Zlotnik, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  12. The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. Gortz, A., Nibbs, R.J., McLean, P., Jarmin, D., Lambie, W., Baird, J.W., Graham, G.J. J. Immunol. (2002) [Pubmed]
  13. ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. Baird, J.W., Nibbs, R.J., Komai-Koma, M., Connolly, J.A., Ottersbach, K., Clark-Lewis, I., Liew, F.Y., Graham, G.J. J. Biol. Chem. (1999) [Pubmed]
  14. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. Hirata, T., Furukawa, Y., Yang, B.G., Hieshima, K., Fukuda, M., Kannagi, R., Yoshie, O., Miyasaka, M. J. Biol. Chem. (2004) [Pubmed]
  15. Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice. Kamiya, N., Jikko, A., Kimata, K., Damsky, C., Shimizu, K., Watanabe, H. J. Bone Miner. Res. (2002) [Pubmed]
  16. Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts. Heino, T.J., Hentunen, T.A., Väänänen, H.K. Exp. Cell Res. (2004) [Pubmed]
  17. TNF family molecule LIGHT regulates chemokine CCL27 expression on mouse embryonic stem cell-derived dendritic cells through NF-kappaB activation. Zou, G.M., Hu, W.Y., Wu, W. Cell. Signal. (2007) [Pubmed]
  18. Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eye. Ledee, D.R., Chen, J., Tonelli, L.H., Takase, H., Gery, I., Zelenka, P.S. Mol. Vis. (2004) [Pubmed]
  19. The alkaline phosphatase activity in DBA/2 and A/JAX mouse strains injected with mouse hepatitis virus 3: a morphological and biochemical comparative study. Sabolovic, N., Gérard, A., Maréchal, J., Gérard, H. Biomed. Pharmacother. (1984) [Pubmed]
WikiGenes - Universities