The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pruritus


Psychiatry related information on Pruritus


High impact information on Pruritus


Chemical compound and disease context of Pruritus


Biological context of Pruritus

  • None of these indices correlated with levels of hemoglobin, PTH, alkaline phosphatase or albumin, or with nerve conduction velocity or any other subsequent clinical outcomes including death, technique failure, hospital days, peritonitis rate and subjective indices of fatigue, pruritus and insomnia [18].
  • The main side effects of megestrol acetate included weight gain (20% or over), pruritus, elevation of blood pressure, weakness, and vaginal bleeding; they were only occasionally observed [19].
  • Visual analog pain scores, sensory changes, blood pressure, heart rate, ephedrine requirements, motor blockade, sedation, pruritus, and nausea were also recorded [20].
  • There was a statistically significant and positive correlation between the pruritus intensity (AUC 0, 72 h) and the malaria parasite load in the itching subjects, not receiving prednisolone (n = 9) (r = 0.73, P = 0.026 ANOVA) [21].
  • Furthermore, with long-term use of mizolastine over 1 year, a reduction in pruritus and the number of urticarial episodes was maintained with no evidence of tachyphylaxis or tolerance [22].

Anatomical context of Pruritus


Gene context of Pruritus


Analytical, diagnostic and therapeutic context of Pruritus


  1. Oral disodium cromoglycate in the treatment of systemic mastocytosis. Soter, N.A., Austen, K.F., Wasserman, S.I. N. Engl. J. Med. (1979) [Pubmed]
  2. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. De Marchi, S., Cecchin, E., Villalta, D., Sepiacci, G., Santini, G., Bartoli, E. N. Engl. J. Med. (1992) [Pubmed]
  3. Paraben allergy. Nagel, J.E., Fuscaldo, J.T., Fireman, P. JAMA (1977) [Pubmed]
  4. Treatment of pruritus of cholestasis by plasma perfusion through USP-charcoal-coated glass beads. Lauterburg, B.H., Taswell, H.F., Pineda, A.A., Dickson, E.R., Burgstaler, E.A., Carlson, G.L. Lancet (1980) [Pubmed]
  5. Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. Bachs, L., Parés, A., Elena, M., Piera, C., Rodés, J. Lancet (1989) [Pubmed]
  6. Secondary hyperparathyroidism in a patient with eight parathyroid glands. Hines, O.J., Gordon, H.E. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  7. Failure of terfenadine as an antipruritic agent in atopic dogs: results of a double-blinded, placebo-controlled study. Scott, D.W., Miller, W.H., Cayatte, S.M., Decker, G.A. Can. Vet. J. (1994) [Pubmed]
  8. Anal pruritus after cancer chemotherapy with gemcitabine. Hejna, M., Valencak, J., Raderer, M. N. Engl. J. Med. (1999) [Pubmed]
  9. A controlled trial of cyclosporine in the treatment of primary biliary cirrhosis. Wiesner, R.H., Ludwig, J., Lindor, K.D., Jorgensen, R.A., Baldus, W.P., Homburger, H.A., Dickson, E.R. N. Engl. J. Med. (1990) [Pubmed]
  10. Cimetidine for the treatment of pruritus. Hess, C.E. N. Engl. J. Med. (1979) [Pubmed]
  11. Pruritus in dialysis patients treated with parenteral lidocaine. Tapia, L., Cheigh, J.S., David, D.S., Sullivan, J.F., Saal, S., Reidenberg, M.M., Stenzel, K.H., Rubin, A.L. N. Engl. J. Med. (1977) [Pubmed]
  12. Improvement of cholestatic pruritus by ondansetron. Schwörer, H., Ramadori, G. Lancet (1993) [Pubmed]
  13. Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy. Kondrackiene, J., Beuers, U., Kupcinskas, L. Gastroenterology (2005) [Pubmed]
  14. Endoprosthesis for internal drainage of the biliary tract. Technique and results in 48 cases. Burcharth, F., Jensen, L.I., Olesen, K. Gastroenterology (1979) [Pubmed]
  15. Subhypnotic doses of propofol relieve pruritus associated with liver disease. Borgeat, A., Wilder-Smith, O.H., Mentha, G. Gastroenterology (1993) [Pubmed]
  16. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. Kaufmann, R., Bieber, T., Helgesen, A.L., Andersen, B.L., Luger, T., Poulin, Y., Al-Hafidh, J., Paul, C. Allergy (2006) [Pubmed]
  17. Sertraline as a first-line treatment for cholestatic pruritus. Mayo, M.J., Handem, I., Saldana, S., Jacobe, H., Getachew, Y., Rush, A.J. Hepatology (2007) [Pubmed]
  18. Lack of correlation between urea kinetic indices and clinical outcomes in CAPD patients. Blake, P.G., Sombolos, K., Abraham, G., Weissgarten, J., Pemberton, R., Chu, G.L., Oreopoulos, D.G. Kidney Int. (1991) [Pubmed]
  19. Megestrol acetate in advanced breast carcinoma after failure to tamoxifen and/or aminoglutethimide. Brufman, G., Isacson, R., Haim, N., Gez, E., Sulkes, A. Oncology (1994) [Pubmed]
  20. The effect of adding a minidose of clonidine to intrathecal sufentanil for labor analgesia. Mercier, F.J., Dounas, M., Bouaziz, H., Des Mesnards-Smaja, V., Foiret, C., Vestermann, M.N., Fischler, M., Benhamou, D. Anesthesiology (1998) [Pubmed]
  21. Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. Adebayo, R.A., Sofowora, G.G., Onayemi, O., Udoh, S.J., Ajayi, A.A. British journal of clinical pharmacology. (1997) [Pubmed]
  22. Clinical advantages of dual activity in urticaria. Kontou-Fili, K. Allergy (2000) [Pubmed]
  23. Raised histamine concentrations in chronic cholestatic liver disease. Gittlen, S.D., Schulman, E.S., Maddrey, W.C. Gut (1990) [Pubmed]
  24. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. Bilsborough, J., Leung, D.Y., Maurer, M., Howell, M., Boguniewcz, M., Yao, L., Storey, H., LeCiel, C., Harder, B., Gross, J.A. J. Allergy Clin. Immunol. (2006) [Pubmed]
  25. Miconazole in the treatment of coccidioidomycosis. Stevens, D.A. Drugs (1983) [Pubmed]
  26. Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. Hansson, L., Bäckman, A., Ny, A., Edlund, M., Ekholm, E., Ekstrand Hammarström, B., Törnell, J., Wallbrandt, P., Wennbo, H., Egelrud, T. J. Invest. Dermatol. (2002) [Pubmed]
  27. A controlled trial of ondansetron in the pruritus of cholestasis. O'Donohue, J.W., Pereira, S.P., Ashdown, A.C., Haigh, C.G., Wilkinson, J.R., Williams, R. Aliment. Pharmacol. Ther. (2005) [Pubmed]
  28. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Dillon, S.R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S.R., Haugen, H.S., Maurer, M., Harder, B., Johnston, J., Bort, S., Mudri, S., Kuijper, J.L., Bukowski, T., Shea, P., Dong, D.L., Dasovich, M., Grant, F.J., Lockwood, L., Levin, S.D., LeCiel, C., Waggie, K., Day, H., Topouzis, S., Kramer, J., Kuestner, R., Chen, Z., Foster, D., Parrish-Novak, J., Gross, J.A. Nat. Immunol. (2004) [Pubmed]
  29. Skin testing of the pruritogenic activity of histamine and cytokines (interleukin-2 and tumour necrosis factor-alpha) at the dermal-epidermal junction. Darsow, U., Scharein, E., Bromm, B., Ring, J. Br. J. Dermatol. (1997) [Pubmed]
  30. Cytokine expression patterns distinguish HIV associated skin diseases. Breuer-McHam, J.N., Ledbetter, L.S., Sarris, A.H., Duvic, M. Exp. Dermatol. (2000) [Pubmed]
  31. The neurogenic vasodilator response to endothelin-1: a study in human skin in vivo. Katugampola, R., Church, M.K., Clough, G.F. Exp. Physiol. (2000) [Pubmed]
  32. B-cell chronic lymphocytic leukemia associated with high serum IGE levels and pruriginous skin lesions: successful therapy with IFN-alpha 2b after failure on IFN-gamma. Neuber, K., Berg-Drewniock, B., Volkenandt, M., Neumaier, M., Zeller, W., Gross, G., Ring, J. Dermatology (Basel) (1996) [Pubmed]
  33. Prolonged cholestasis due to trimethoprim sulfamethoxazole. Kowdley, K.V., Keeffe, E.B., Fawaz, K.A. Gastroenterology (1992) [Pubmed]
  34. Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile. Kurbegov, A.C., Setchell, K.D., Haas, J.E., Mierau, G.W., Narkewicz, M., Bancroft, J.D., Karrer, F., Sokol, R.J. Gastroenterology (2003) [Pubmed]
  35. Antimitochondrial antibodies in kindreds of patients with primary biliary cirrhosis: antimitochondrial antibodies are unique to clinical disease and are absent in asymptomatic family members. Caldwell, S.H., Leung, P.S., Spivey, J.R., Prindiville, T., de Medina, M., Saicheur, T., Rowley, M., Reddy, K.R., Coppel, R., Jeffers, L.J. Hepatology (1992) [Pubmed]
  36. Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders. Fitton, A., Wiseman, L. Drugs (1996) [Pubmed]
WikiGenes - Universities