Disease relevance of Octylguanidine

• Myocardial protective effect of octylguanidine against the damage induced by ischemia reperfusion in rat heart [1].
• ECG tracings from rats treated with an i.v., injection of 5 mg/kg of octylguanidine showed a total absence of post-reperfusion arrhythmias, conversely to what was observed in untreated rats [1].
• We propose that the protective effect of octylguanidine might be due to its documented inhibitory action on the opening of mitochondrial non-specific pores, a mechanism which is associated in heart injury as induced by reperfusion [1].

High impact information on Octylguanidine

• Inactivation of mitochondrial permeability transition pore by octylguanidine and octylamine [2].
• 5. Octylguanidine inhibits the ATPase activity of sonic submitochondrial particles with a hyperbolic titration-curve analogous to that obtained for oligomycin inhibition [3].
• A kinetic explanation is given for the reported higher sensitivity of site I phosphorylation to octylguanidine [3].
• The octylguanidine-curve for inhibition of succinate oxidation is sigmoid with half-maximal inhibition at about 250 muM [3].
• The effect of octylguanidine and oligomycin on the oxygen uptake of rat liver mitochondria and on the ATPase activity of "sonic" submitochondrial particles has been studied [3].

References