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Chemical Compound Review:

MBzP 2-phenylmethoxycarbonylbenzoic acid

Synonyms: SureCN116566, AG-E-77005, CBDivE_003018, ACMC-20ajvz, NSC-402008, ...

Lampen, A. et al., Kim, K.S. et al., Jepsen, K.F. et al., Xu, X.R. et al., Ema, M. et al., et al.

Lampen, Zimnik, Nau, Xu, Li, Gu, Li,

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Disease relevance of Benzyl hydrogen phthalate

Characterization of developmental toxicity of mono-n-benzyl phthalate in rats [1].

High impact information on Benzyl hydrogen phthalate

Only the five test compounds, mono-2-ethyl-hexyl-phthatate, mono-1-methyl-heptyl-phthalate, mono-benzyl-phthalate, benzyl-butyl-phthalate, and 2-ethyl-hexanoic acid activated PPARdelta and interacted with a specific PPARdelta-response element [2].
In the F9 cell assay only five compounds, mono-2-ethyl-hexyl-phthalate, mono-1-methyl-heptyl-phthalate, mono-benzyl-phthalate, benzyl-butyl-phthalate, and 2-ethyl-hexanoic acid were found to induce F9 cell differentiation [2].
The major metabolites of BBP degradation were identified as mono-butyl phthalate, mono-benzyl phthalate, phthalic acid and benzoic acid by gas chromatography-mass spectrometry, and a preliminary metabolic pathway of BBP was proposed [3].
The human epithelial cell line A549 was exposed to 15.6-2000 microg/ml, in two-fold dilutions, to either mono-n-butyl phthalate, monobenzyl phthalate, mono-n-octyl phthalate, mono-2-ethylhexyl phthalate, mono-iso-nonyl phthalate or mono-iso-decyl phthalate [4].
A glucopyranosyl benzyl phthalate, two mannopyranosyl benzyl phthalates, and a 2-deoxyglucopyranosyl benzyl phthalate, which were prepared from the corresponding 1-hydroxy sugars and benzyl hydrogen phthalate, were found to be efficient glycosyl donors in the glycosylations of various glycosyl acceptors using TMSOTf as a promoter [5].

Chemical compound and disease context of Benzyl hydrogen phthalate

Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats [6].

References

Characterization of developmental toxicity of mono-n-benzyl phthalate in rats. Ema, M., Harazono, A., Miyawaki, E., Ogawa, Y. Reprod. Toxicol. (1996) [Pubmed]
Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells. Lampen, A., Zimnik, S., Nau, H. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
Kinetics of n-butyl benzyl phthalate degradation by a pure bacterial culture from the mangrove sediment. Xu, X.R., Li, H.B., Gu, J.D., Li, X.Y. J. Hazard. Mater. (2007) [Pubmed]
Monophthalates promote IL-6 and IL-8 production in the human epithelial cell line A549. Jepsen, K.F., Abildtrup, A., Larsen, S.T. Toxicology in vitro : an international journal published in association with BIBRA. (2004) [Pubmed]
Glycosylation with glycosyl benzyl phthalates as a new type of glycosyl donor. Kim, K.S., Lee, Y.J., Kim, H.Y., Kang, S.S., Kwon, S.Y. Org. Biomol. Chem. (2004) [Pubmed]
Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats. Ema, M., Harazono, A., Miyawaki, E., Ogawa, Y. Toxicol. Lett. (1996) [Pubmed]

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