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Chemical Compound Review

Spatozoate     butyl benzyl benzene-1,2-dicarboxylate

Synonyms: Sicol, Palatinol BB, Ketjenflex 160, Santicizer 160, Unimoll BB, ...
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Psychiatry related information on Palatinol BB

  • In a laboratory experiment we documented effects of sublethal concentrations of p,p'-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE) and butylbenzylphthalate (BBP) on feeding behavior in threespine stickleback Gasterosteus aculeatus [1].

High impact information on Palatinol BB


Biological context of Palatinol BB


Anatomical context of Palatinol BB

  • From these results, limb bud cells responded more sensitively to BBP and DBP than mid-brain cells [5].
  • In this study, the embryotoxicity of ESBO and phthalate esters, namely, diethyl hexyl phthalate (DEHP), butylbenzyl phthalate (BBP) and dibutyl phthalate (DBP) was evaluated using short-term in vitro battery system, such as the whole embryo, midbrain and limb bud culture systems [5].

Associations of Palatinol BB with other chemical compounds

  • A dramatic and dose-dependent increase in hepatic MDA levels was observed in CF (100 mg/kg), DEHP (>or=50 mg/kg), DBP and BBP (>or=200 mg/kg) groups [6].
  • The permeated amounts of these chemicals within 180 min in the apical to basolateral (A-to-B) and the basolateral to apical (B-to-A) directions without verapamil, a P-glycoprotein (P-gp) inhibitor, were in the rank order of tBP > tOP > BPA > DOP > DBP > BBP and BPA >> tBP > tOP > DOP > DBP > BBP, respectively [7].


  1. Postexposure effects of DDE and butylbenzylphthalate on feeding behavior in threespine stickleback. Wibe, A.E., Fjeld, E., Rosenqvist, G., Jenssen, B.M. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
  2. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. Fujita, T., Kobayashi, Y., Wada, O., Tateishi, Y., Kitada, L., Yamamoto, Y., Takashima, H., Murayama, A., Yano, T., Baba, T., Kato, S., Kawabe, Y., Yanagisawa, J. J. Biol. Chem. (2003) [Pubmed]
  3. Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Marsee, K., Woodruff, T.J., Axelrad, D.A., Calafat, A.M., Swan, S.H. Environ. Health Perspect. (2006) [Pubmed]
  4. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Jobling, S., Reynolds, T., White, R., Parker, M.G., Sumpter, J.P. Environ. Health Perspect. (1995) [Pubmed]
  5. Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system. Seek Rhee, G., Hee Kim, S., Sun Kim, S., Hee Sohn, K., Jun Kwack, S., Ho Kim, B., Lea Park, K. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
  6. Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Seo, K.W., Kim, K.B., Kim, Y.J., Choi, J.Y., Lee, K.T., Choi, K.S. Food Chem. Toxicol. (2004) [Pubmed]
  7. Permeability characteristics of endocrine-disrupting chemicals using an in vitro cell culture model, Caco-2 cells. Yoshikawa, Y., Hayashi, A., Inai, M., Matsushita, A., Shibata, N., Takada, K. Curr. Drug Metab. (2002) [Pubmed]
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