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Chemical Compound Review:

Spatozoate butyl benzyl benzene-1,2-dicarboxylate

Synonyms: Sicol, Palatinol BB, Ketjenflex 160, Santicizer 160, Unimoll BB, ...

Seek Rhee, G. et al., Jobling, S. et al., Wibe, A.E. et al., Yoshikawa, Y. et al., Fujita, T. et al., et al.

Seo, Kim, Kim, Choi, Lee, Choi, Wibe, Fjeld, Rosenqvist, Jenssen,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on Palatinol BB

In a laboratory experiment we documented effects of sublethal concentrations of p,p'-2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE) and butylbenzylphthalate (BBP) on feeding behavior in threespine stickleback Gasterosteus aculeatus [1].

High impact information on Palatinol BB

Recently, one of the phthalate esters, n-butylbenzyl phthalate (BBP), has been shown to induce estrogen receptor-mediated responses [2].
The U.S. Environmental Protection Agency (EPA) reference doses for these chemicals are 100 (DBP) , 800 (DEP) , 200 (BBzP) , and 20 (DEHP) microg/kg/day [3].
Neither BBP nor DBP were able to act as antagonists, indicating that, in the presence of endogenous estrogens, their overall effect would be cumulative [4].
Further studies, using mammalian estrogen screens in vitro, revealed that the two phthalate esters butylbenzyl phthalate (BBP) and di-n-butylphthalate (DBP) and a food antioxidant, butylated hydroxyanisole (BHA) were estrogenic; however, they were all less estrogenic than the environmental estrogen octylphenol [4].
Postexposure effects of DDE and butylbenzylphthalate on feeding behavior in threespine stickleback [1].

Biological context of Palatinol BB

By using the truncated types of ER mutants, we revealed that activation function-1 (AF-1) activity was necessary for the BBP-dependent transactivation function of ERalpha [2].
The IC(50) of limb bud cell differentiation and cytotoxicity in DBP is 1.9 and 7.1 less than that of BBP [5].

Anatomical context of Palatinol BB

From these results, limb bud cells responded more sensitively to BBP and DBP than mid-brain cells [5].
In this study, the embryotoxicity of ESBO and phthalate esters, namely, diethyl hexyl phthalate (DEHP), butylbenzyl phthalate (BBP) and dibutyl phthalate (DBP) was evaluated using short-term in vitro battery system, such as the whole embryo, midbrain and limb bud culture systems [5].

Associations of Palatinol BB with other chemical compounds

A dramatic and dose-dependent increase in hepatic MDA levels was observed in CF (100 mg/kg), DEHP (>or=50 mg/kg), DBP and BBP (>or=200 mg/kg) groups [6].
The permeated amounts of these chemicals within 180 min in the apical to basolateral (A-to-B) and the basolateral to apical (B-to-A) directions without verapamil, a P-glycoprotein (P-gp) inhibitor, were in the rank order of tBP > tOP > BPA > DOP > DBP > BBP and BPA >> tBP > tOP > DOP > DBP > BBP, respectively [7].

References

Postexposure effects of DDE and butylbenzylphthalate on feeding behavior in threespine stickleback. Wibe, A.E., Fjeld, E., Rosenqvist, G., Jenssen, B.M. Ecotoxicol. Environ. Saf. (2004) [Pubmed]
Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. Fujita, T., Kobayashi, Y., Wada, O., Tateishi, Y., Kitada, L., Yamamoto, Y., Takashima, H., Murayama, A., Yano, T., Baba, T., Kato, S., Kawabe, Y., Yanagisawa, J. J. Biol. Chem. (2003) [Pubmed]
Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Marsee, K., Woodruff, T.J., Axelrad, D.A., Calafat, A.M., Swan, S.H. Environ. Health Perspect. (2006) [Pubmed]
A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Jobling, S., Reynolds, T., White, R., Parker, M.G., Sumpter, J.P. Environ. Health Perspect. (1995) [Pubmed]
Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system. Seek Rhee, G., Hee Kim, S., Sun Kim, S., Hee Sohn, K., Jun Kwack, S., Ho Kim, B., Lea Park, K. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Seo, K.W., Kim, K.B., Kim, Y.J., Choi, J.Y., Lee, K.T., Choi, K.S. Food Chem. Toxicol. (2004) [Pubmed]
Permeability characteristics of endocrine-disrupting chemicals using an in vitro cell culture model, Caco-2 cells. Yoshikawa, Y., Hayashi, A., Inai, M., Matsushita, A., Shibata, N., Takada, K. Curr. Drug Metab. (2002) [Pubmed]

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