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Chemical Compound Review

Pronamid     3,5-dichloro-N-(2-methylbut- 3-yn-2...

Synonyms: PRONAMIDE, Clanex, Propyzamide, KERB, PS349_SUPELCO, ...
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High impact information on Clanex

  • The touch-dependent sku6 root skewing phenotype is suppressed by the antimicrotubule drugs propyzamide and oryzalin, and right skewing is exacerbated by cold treatment [1].
  • The erh2-1 and rhd3-1 mutants differed from other anisotropic cell expansion mutants, though, by an inability to respond to low doses of the microtubule-binding drug propyzamide, which normally causes enhanced left-handed CFR and right skewing [2].
  • Furthermore, both filamentous actin and spindle bodies disappeared in the cells treated with propyzamide, which depolymerizes microtubules, supporting the notion that actin filaments are associated with microtubules organizing the spindle body [3].
  • Propyzamide and oryzalin cause the accumulation of membrane tubules or vacuoles in the tip that reverse direction and stream in a reverse fountain [4].
  • Applications of amiprophosmethyl, propyzamide or oryzalin, which all disrupt microtubules, stop growth, alter organelle motility within the tip, and alter the organization of actin microfilaments [4].

Biological context of Clanex

  • The term "superhaplotype" is suggested for gene constellations such as the HL-A9, RH-315, 12 "haplotype". It is suggested that the associations between cross-reacting antigens from one series with the same antigen from another series may reflect recent evolutionary divergence of the cross-reacting antigens [5].
  • Northern blot analysis of BY-2 cells synchronized with aphidicolin or a combination of aphidicolin and propyzamide showed that the histone H4 gene was specifically expressed in the S phase but NtFib1 mRNA remained at high levels during the cell cycle [6].
  • A cell synchrony starting from S phase is obtained after release of BY-2 cells from aphidicolin treatment, while that from M phase is available after release from a sequential treatment of aphidicolin followed by propyzamide [7].

Anatomical context of Clanex


  1. The Arabidopsis sku6/spiral1 gene encodes a plus end-localized microtubule-interacting protein involved in directional cell expansion. Sedbrook, J.C., Ehrhardt, D.W., Fisher, S.E., Scheible, W.R., Somerville, C.R. Plant Cell (2004) [Pubmed]
  2. Loss-of-function mutations of ROOT HAIR DEFECTIVE3 suppress root waving, skewing, and epidermal cell file rotation in Arabidopsis. Yuen, C.Y., Sedbrook, J.C., Perrin, R.M., Carroll, K.L., Masson, P.H. Plant Physiol. (2005) [Pubmed]
  3. Localization of actin filaments on mitotic apparatus in tobacco BY-2 cells. Yasuda, H., Kanda, K., Koiwa, H., Suenaga, K., Kidou, S., Ejiri, S. Planta (2005) [Pubmed]
  4. Microtubules and microfilaments coordinate to direct a fountain streaming pattern in elongating conifer pollen tube tips. Justus, C.D., Anderhag, P., Goins, J.L., Lazzaro, M.D. Planta (2004) [Pubmed]
  5. HL-A antigen, gene, and haplotype frequencies in Denmark. Staub Nielsen, L., Jersild, C., Ryder, L.P., Svejgaard, A. Tissue Antigens (1975) [Pubmed]
  6. Molecular cloning and gene expression of a fibrillarin homolog of tobacco BY-2 cells. Makimoto, Y., Yano, H., Kaneta, T., Sato, Y., Sato, S. Protoplasma (2006) [Pubmed]
  7. Plant cell biology through the window of the highly synchronized tobacco BY-2 cell line. Nagata, T., Kumagai, F. Methods in cell science : an official journal of the Society for In Vitro Biology. (1999) [Pubmed]
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