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Chemical Compound Review

Tokunol M     N-[methoxy-(4-methyl-2- nitro...

Synonyms: SureCN116428, NTN 80, AG-F-25249, CHEMBL1256629, NSC-313446, ...
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Disease relevance of Tokunol M

  • The upA12 mutation caused twofold resistance to amiprophos-methyl and oryzalin, and twofold hypersensitivity to the microtubule-stabilizing drug taxol, suggesting that the mutation enhanced microtubule stability [1].
  • Following 2-year trials, amiprofos-methyl (APM) was found to be superior to oryzalin on the basis of a lower toxicity, and we were able to narrow the range of concentrations of APM [2].

High impact information on Tokunol M


Biological context of Tokunol M


Anatomical context of Tokunol M


Associations of Tokunol M with other chemical compounds


Gene context of Tokunol M


Analytical, diagnostic and therapeutic context of Tokunol M

  • Exposure of the early-log phase suspension culture to 32muM APM led to a marked increase in the MI 12 and 24h after treatment, while higher as well as lower concentrations (16, 24 and 48muM) had no effect [19].


  1. A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii confers resistance to anti-microtubule herbicides. James, S.W., Silflow, C.D., Stroom, P., Lefebvre, P.A. J. Cell. Sci. (1993) [Pubmed]
  2. Chromosome doubling procedures of onion (Allium cepa L.) gynogenic embryos. Jakse, M., Havey, M.J., Bohanec, B. Plant Cell Rep. (2003) [Pubmed]
  3. A MAP kinase is activated late in plant mitosis and becomes localized to the plane of cell division. Bögre, L., Calderini, O., Binarova, P., Mattauch, M., Till, S., Kiegerl, S., Jonak, C., Pollaschek, C., Barker, P., Huskisson, N.S., Hirt, H., Heberle-Bors, E. Plant Cell (1999) [Pubmed]
  4. Nuclear fusion-defective phenocopies in Chlamydomonas reinhardtii: mating-type functions for meiosis can act through the cytoplasm. Dutcher, S.K. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  5. Covalent binding of the benzamide RH-4032 to tubulin in suspension-cultured tobacco cells and its application in a cell-based competitive-binding assay. Young, D.H., Lewandowski, V.T. Plant Physiol. (2000) [Pubmed]
  6. Plant cell growth responds to external forces and the response requires intact microtubules. Wymer, C.L., Wymer, S.A., Cosgrove, D.J., Cyr, R.J. Plant Physiol. (1996) [Pubmed]
  7. Mutants resistant to anti-microtubule herbicides map to a locus on the uni linkage group in Chlamydomonas reinhardtii. James, S.W., Ranum, L.P., Silflow, C.D., Lefebvre, P.A. Genetics (1988) [Pubmed]
  8. Effects of amiprophosmethyl on massive and limited calcium loading of maize mitochondria. Hertel, C., Affolter, H., Marme, D., Dierks-Ventling, C. Biochem. J. (1983) [Pubmed]
  9. Drugs with colchicine-like effects that specifically disassemble plant but not animal microtubules. Bajer, A.S., Molè-Bajer, J. Ann. N. Y. Acad. Sci. (1986) [Pubmed]
  10. Isolation and characterization of dominant, pleiotropic drug-resistance mutants in Chlamydomonas reinhardtii. James, S.W., Lefebvre, P.A. Curr. Genet. (1989) [Pubmed]
  11. Microtubule distribution in gravitropic protonemata of the moss Ceratodon. Schwuchow, J., Sack, F.D., Hartmann, E. Protoplasma (1990) [Pubmed]
  12. Microtubules and microfilaments coordinate to direct a fountain streaming pattern in elongating conifer pollen tube tips. Justus, C.D., Anderhag, P., Goins, J.L., Lazzaro, M.D. Planta (2004) [Pubmed]
  13. Microtubules restrict plastid sedimentation in protonemata of the moss Ceratodon. Schwuchow, J., Sack, F.D. Cell Motil. Cytoskeleton (1994) [Pubmed]
  14. Roles of microtubules and cellulose microfibril assembly in the localization of secondary-cell-wall deposition in developing tracheary elements. Roberts, A.W., Frost, A.O., Roberts, E.M., Haigler, C.H. Protoplasma (2004) [Pubmed]
  15. The action of antimitotic herbicides on flagellar regeneration in Chlamydomonas reinhardtii: a comparison with the action of colchicine. Quader, H., Filner, P. Eur. J. Cell Biol. (1980) [Pubmed]
  16. Turgor pressure regulation and the orientation of cortical microtubules in Spirogyra cells. Iwata, K., Tazawa, M., Itoh, T. Plant Cell Physiol. (2001) [Pubmed]
  17. Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants. Kawahigashi, H., Hirose, S., Ozawa, K., Ido, Y., Kojima, M., Ohkawa, H., Ohkawa, Y. Transgenic Res. (2005) [Pubmed]
  18. Structure, synthesis and orientation of microfibrils. V. On the recovery of Oocystis solitaria from microtubule inhibitor treatment. Quader, H., Wagenbreth, I., Robinson, D.G. Cytobiologie. (1978) [Pubmed]
  19. Isolation of microprotoplasts from a partially synchronized suspension culture of Citrus unshiu. Zhang, Q., Liu, J., Deng, X. J. Plant Physiol. (2006) [Pubmed]
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