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Chemical Compound Review:

AG-E-76724 3,4-dimethylhexane-2,5-dione

Synonyms: AC1L1OJO, LS-75117, CTK4F5262, 25234-79-1, EINECS 246-746-2, ...

Kim, M.S. et al., Horan, K.L. et al., Boekelheide, K., Sabri, M.I., Griffin, J.W. et al.

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High impact information on EINECS 246-746-2

3,4-Dimethyl-2,5-hexanedione impairs the axonal transport of neurofilament proteins [1].
Changes began with the formation of proximal, neurofilament-filled axonal swellings of the type seen after treatment with 3,4-dimethyl-2,5-hexanedione, a potent derivative of the active metabolite of the neurotoxic aliphatic hydrocarbon solvents n-hexane and methyl n-butyl ketone [2].
Animals intoxicated with 3,4-dimethyl-2,5-hexanedione for 12 days showed proximal region increases in phosphorylation of the 55 and 180 kDa proteins and the major myelin proteins, Po and Pr [3].
In vitro incubation with the 2,5-HD congener 3,4-dimethyl-2,5-hexanedione produced similar alterations in microtubule assembly [4].

Anatomical context of EINECS 246-746-2

Effect of 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione on retrograde axonal transport in sciatic nerve [5].

References

3,4-Dimethyl-2,5-hexanedione impairs the axonal transport of neurofilament proteins. Griffin, J.W., Anthony, D.C., Fahnestock, K.E., Hoffman, P.N., Graham, D.G. J. Neurosci. (1984) [Pubmed]
1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Kim, M.S., Sabri, M.I., Miller, V.H., Kayton, R.J., Dixon, D.A., Spencer, P.S. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
Hexanedione effects on protein phosphorylation in rat peripheral nerve. Horan, K.L., Eichberg, J., Berti-Mattera, L.N., LoPachin, R.M. Brain Res. (1989) [Pubmed]
2,5-Hexanedione alters microtubule assembly. II. Enhanced polymerization of crosslinked tubulin. Boekelheide, K. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
Effect of 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione on retrograde axonal transport in sciatic nerve. Sabri, M.I. Neurochem. Res. (1992) [Pubmed]

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