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Chemical Compound Review

Etotoina     3-ethyl-5-phenyl- imidazolidine-2,4-dione

Synonyms: Peganone, ethotoin, Accenon, Ethotoine, Pegoanone, ...
 
 
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Disease relevance of D00708

 

High impact information on D00708

 

Associations of D00708 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of D00708

  • Plasma samples were collected for 49 hr after dosing and were assayed by HPLC for ethotoin [6].
  • In a retrospective study, records of 46 patients (24 women and 22 men aged 17-51 years; mean 29.2 years), who had been treated with ethotoin (EHN) as adjunctive therapy for control of intractable seizures were reviewed [7].
  • Stereoselective analysis of the enantiomers of ethotoin in human serum using chiral stationary phase liquid chromatography and gas chromatography-mass spectrometry [10].

References

  1. Cleft lip and palate with the anticonvulsant ethotoin. Zablen, M., Brand, N. N. Engl. J. Med. (1977) [Pubmed]
  2. Hydantoin-induced teratogenesis: are arene oxide intermediates really responsible? Finnell, R.H., DiLiberti, J.H. Helvetica paediatrica acta. (1983) [Pubmed]
  3. Clinical pharmacology of mephenytoin and ethotoin. Troupin, A.S., Friel, P., Lovely, M.P., Wilensky, A.J. Ann. Neurol. (1979) [Pubmed]
  4. Role of microtubule assembly in phenytoin teratogenic action in the sea urchin (Arbacia punctulata) embryo. Estus, S., Blumer, J.L. Mol. Pharmacol. (1989) [Pubmed]
  5. Ethotoin in seizures of childhood and adolescence. Carter, C.A., Helms, R.A., Boehm, R. Neurology (1984) [Pubmed]
  6. Nonlinear ethotoin kinetics. Meyer, M.C., Holcombe, B.J., Burckart, G.J., Raghow, G., Yau, M.K. Clin. Pharmacol. Ther. (1983) [Pubmed]
  7. Adjunctive therapy for intractable epilepsy with ethotoin. Biton, V., Gates, J.R., Ritter, F.J., Loewenson, R.B. Epilepsia (1990) [Pubmed]
  8. Enantioselective pharmacokinetics of ethotoin in humans following single oral doses of the racemate. Hooper, W.D., O'Shea, N.J., Qing, M.S. Chirality. (1992) [Pubmed]
  9. Simultaneous rapid HPLC determination of anticonvulsant drugs in plasma and correlation with EMIT. Rydzewski, R.S., Gadsden, R.H., Phelps, C.A. Ann. Clin. Lab. Sci. (1980) [Pubmed]
  10. Stereoselective analysis of the enantiomers of ethotoin in human serum using chiral stationary phase liquid chromatography and gas chromatography-mass spectrometry. Inotsume, N., Fujii, J., Honda, M., Nakano, M., Higashi, A., Matsuda, I. J. Chromatogr. (1988) [Pubmed]
 
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