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Chemical Compound Review

Abbott     1,2-dipropan-2-yl-1,2,4- triazolidine-3,5...

Synonyms: NSC-30379, NSC30379, CTK8J0457, LS-156244, NSC 30379, ...
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Disease relevance of Abbott

  • Bragdon v. Abbott: the Americans with Disabilities Act and HIV infection [1].
  • Among patients with chronic active hepatitis (7%), 80% were anti-HCV positive by the Abbott test (P = 0.002), and 75% were anti-HCV positive by the UBI assay (P less than 0.001) [2].
  • RESULTS: Among patients with cirrhosis (32%), 62% were anti-HCV positive by the Abbott test (P = 0.006), and 41% were anti-HCV positive by the UBI assay (P = 0.007) [2].
  • With this assay the capacity of anti-HBs antibodies to inhibit the binding of hepatitis B surface antigen (HBsAg) with solid-phase anti-HBs (Ausria II, Abbott Laboratories) was studied [3].
  • Determination of estrogen receptor content in 82 breast cancer specimens with immunocytochemical estrogen receptor assay (ER-EIA) (Abbott) was compared with our routinely used binding assay using 125I-estradiol as radioligand with Scatchard plot analysis of the binding data [4].

Psychiatry related information on Abbott

  • Patient specimens (n = 34) were tested in the laboratory using both Abbott Laboratories ADx (ADx) and EZ-SCREEN (EZS-LAB), and by the nursing staff of an inpatient substance abuse treatment program using the EZ-SCREEN (EZS-RN) [5].
  • A recent article (Klapp, Abbott, Coffman, Greim, Snider, and Young, 1979) has concluded that central time demands of motor programming can only be determined by choice reaction time methodology [6].
  • Abbott and SFH shared a common vision for the project and enhanced their partnership through increased communication and problem solving [7].
  • Walkup and Abbott (1978) stated that Edwards and Ashworth's (1977) failure to replicate Bem's (1974) selection of items for the Masculinity and Femininity Scales of the Bern Sex Role Inventory (BSRI) may be attributed to differences in the instructions and anchored rating scales used in the two studies [8].
  • OBJECTIVE: This study sought to determine the effectiveness of a recently developed educational patient compliance program (A Taste for Life [1995]; Abbott Laboratories, Abbott Park, IL) on improving serum phosphate levels in patients receiving hemodialysis [9].

High impact information on Abbott


Chemical compound and disease context of Abbott


Biological context of Abbott


Anatomical context of Abbott

  • Estrogen receptor determinations have been performed on 241 cytosols from 160 breast cancer tumors using both radioactive ligands ([3H])-estradiol, [3H]R2858) and monoclonal antibodies (Abbott ER-EIA Kit) in order to compare the two methods and to evaluate the clinical usefulness of the new immunological, simplified assay [24].
  • RESULTS: Abbott HIV-1-EIA kits detected non-neutralizable antigens in early post-transplantation sera from 12 kidney, five bone-marrow and two heart recipients [25].
  • Tissue recombinant experiments show that the mutation affects the ectoderm, extending the time it responds to ridge induction (R.A. Fraser and U.K. Abbott (1971). J. Exp. Zool. 176, 237-248) while the mesoderm is normal [26].
  • We established a reference interval with both the Abbott IMx microparticle enzyme-linked immunoassay (EIA) (0.6-2.0 mg/L) and the Pharmacia beta 2-micro EIA 96 method (0.8-2.2 mg/L) for beta 2-microglobulin in cerebrospinal fluid [27].
  • Bilirubin in amniotic fluid does not interfere with the Abbott TDx FLM II assay [28].

Associations of Abbott with other chemical compounds


Gene context of Abbott


Analytical, diagnostic and therapeutic context of Abbott

  • Antibody to HCV (anti-HCV) positivity as defined by a repeatedly-reactive enzyme immunoassay and a positive neutralization enzyme immunoassay (Abbott Laboratories, Chicago, Ill) [37].
  • A commercially available solid phase radioimmunoassay for antibody to HBSAg (Ausab, Abbott Laboratories North Chicago, Ill.) has been modified to detect the subtypes of HBSAg as well as the subtype-specific anti-HBS reactivities to detect the subtypes of HBSAg as well as the subtype-specific anti-HBS reactivities (anti-d, anti-y, and anti-w) [38].
  • Monoclonal H222sp gamma and peroxidase antiperoxidase procedures (Abbott kit) were applied in frozen sections, tumor imprints, and fine-needle aspirates [39].
  • METHODS: Archived sera obtained from 163 kidney transplant recipients at the time of transplantation were tested for anti-HCV using the Abbott HCV 2.0 second-generation test system [40].
  • AdbetaGal (5 x 10(9) plaque-forming units) and AAV2betaGal (5.3 x 10(9) DNase-resistant particles) were used to coat BiodivYsio stents with matrix HI coating (Abbott Vascular Devices, Galway, Ireland) [41].


  1. Bragdon v. Abbott: the Americans with Disabilities Act and HIV infection. Neiburger, E.J. N. Engl. J. Med. (1999) [Pubmed]
  2. High prevalence of viral infection in adults with homozygous and heterozygous alpha 1-antitrypsin deficiency and chronic liver disease. Propst, T., Propst, A., Dietze, O., Judmaier, G., Braunsteiner, H., Vogel, W. Ann. Intern. Med. (1992) [Pubmed]
  3. Anti-hepatitis B virus activity of a mixture of two monoclonal antibodies in an "inhibition in solution" assay. Heijtink, R.A., Kruining, J., Weber, Y.A., de Man, R.A., Schalm, S.W. Hepatology (1995) [Pubmed]
  4. Comparison of immunocytochemical estrogen receptor assay, estrogen receptor enzyme immunoassay, and radioligand-labeled estrogen receptor assay in human breast cancer and uterine tissue. Heubner, A., Beck, T., Grill, H.J., Pollow, K. Cancer Res. (1986) [Pubmed]
  5. Evaluation of a point-of-care testing product for drugs of abuse; testing site is a key variable. Kranzler, H.R., Stone, J., McLaughlin, L. Drug and alcohol dependence. (1995) [Pubmed]
  6. Methods in the study of motor programming: is it just a matter of simple vs. choice reaction time? A comment on Klapp et al. (1979). Martenuik, R.G., MacKenzie, C.L. Journal of motor behavior. (1981) [Pubmed]
  7. Case study: improving efficiency in a large hospital laboratory. Bartel, M. Clinical leadership & management review : the journal of CLMA. (2004) [Pubmed]
  8. Effects of instructions and rating scales on item selection for the BSRI scales. Ramanaiah, N.V., Hoffman, S.C. Journal of personality assessment. (1984) [Pubmed]
  9. The effect of an educational patient compliance program on serum phosphate levels in patients receiving hemodialysis. Shaw-Stuart, N.J., Stuart, A. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. (2000) [Pubmed]
  10. Membrane ion channels of endothelial cells. Revest, P.A., Abbott, N.J. Trends Pharmacol. Sci. (1992) [Pubmed]
  11. A natural case of RIP: degeneration of the DNA sequence in an ancestral tandem duplication. Grayburn, W.S., Selker, E.U. Mol. Cell. Biol. (1989) [Pubmed]
  12. The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Peichel, C.L., Prabhakaran, B., Vogt, T.F. Development (1997) [Pubmed]
  13. Comparison of a novel assay for breast cancer mucin to CA15-3 and carcinoembryonic antigen. Daly, L., Ferguson, J., Cram, G.P., Hars, V., George, S.L., McCarty, K.S., Bast, R.C. J. Clin. Oncol. (1992) [Pubmed]
  14. Determination of estrogen receptor in breast cancer using monoclonal antibody technology: results of a multicenter study in the United States. Jordan, V.C., Jacobson, H.I., Keenan, E.J. Cancer Res. (1986) [Pubmed]
  15. Hepatitis-B surface antigen and cirrhosis in Iraq. Boxall, E.H., Flewett, T.H., Paton, A., Rassam, S.W. Gut (1976) [Pubmed]
  16. HIV surveillance by testing saliva. Johnson, A.M., Parry, J.V., Best, S.J., Smith, A.M., de Silva, M., Mortimer, P.P. AIDS (1988) [Pubmed]
  17. Extreme central acidosis from Abbott epinephrine. Feldschuh, J., Gambino, R. Am. J. Med. (1983) [Pubmed]
  18. Estrogen and progesterone receptor assays, by the EIA method (Abbott), of low-speed supernates of breast-cancer homogenates. Hähnel, R., Avenell, M.H., Hähnel, E. Clin. Chem. (1989) [Pubmed]
  19. Localization of the high-affinity binding site for ATP on the membrane-bound chloroplast ATP synthase. Abbott, M.S., Czarnecki, J.J., Selman, B.R. J. Biol. Chem. (1984) [Pubmed]
  20. Fight for reputation. Judah Folkman counter-sued Abbott in the legal battle over kringle 5. Brower, V. EMBO Rep. (2000) [Pubmed]
  21. Influence of timing on the analgesic effect of intravenous ketorolac after orthopedic surgery. Fletcher, D., Zetlaoui, P., Monin, S., Bombart, M., Samii, K. Pain (1995) [Pubmed]
  22. CYP3A5 genotype does not influence the blood concentration of tacrolimus measured with the Abbott immunoassay. Moreton, M., Fredericks, S., McKeown, D.A., Shiferaw, E.W., MacPhee, I.A., Johnston, A., Holt, D.W. Clin. Chem. (2005) [Pubmed]
  23. The Abbott IMx automated benchtop immunochemistry analyzer system. Fiore, M., Mitchell, J., Doan, T., Nelson, R., Winter, G., Grandone, C., Zeng, K., Haraden, R., Smith, J., Harris, K. Clin. Chem. (1988) [Pubmed]
  24. Comparison of monoclonal antibodies and tritiated ligands for estrogen receptor assays in 241 breast cancer cytosols. Goussard, J., Lechevrel, C., Martin, P.M., Roussel, G. Cancer Res. (1986) [Pubmed]
  25. False-positive HIV antigens related to emergence of a 25-30 kD protein detected in organ recipients. Agbalika, F., Ferchal, F., Garnier, J.P., Eugène, M., Bedrossian, J., Lagrange, P.H. AIDS (1992) [Pubmed]
  26. Experimental manipulation leading to induction of dorsal ectodermal ridges on normal limb buds results in a phenocopy of the Eudiplopodia chick mutant. Carrington, J.L., Fallon, J.F. Dev. Biol. (1986) [Pubmed]
  27. Establishment of a reference interval for beta 2-microglobulin in cerebrospinal fluid with use of two commercial assays. Lutz, C.T., Cornell, S.H., Goeken, J.A. Clin. Chem. (1991) [Pubmed]
  28. Bilirubin in amniotic fluid does not interfere with the Abbott TDx FLM II assay. Cariappa, R., Parvin, C.A., Gronowski, A.M. Clin. Chem. (2003) [Pubmed]
  29. Effect of low-dose methotrexate on the disposition of glucocorticoids and theophylline. Glynn-Barnhart, A.M., Erzurum, S.C., Leff, J.A., Martin, R.J., Cochran, J.E., Cott, G.R., Szefler, S.J. J. Allergy Clin. Immunol. (1991) [Pubmed]
  30. Digoxin-like immunoreactivity in the serum of neonates and uremic patients, as measured in the Abbott TDX. Yatscoff, R.W., Desjardins, P.R., Dalton, J.G. Clin. Chem. (1984) [Pubmed]
  31. Method comparison for total plasma homocysteine between the Abbott IMx analyzer and an HPLC assay with internal standardization. Pfeiffer, C.M., Twite, D., Shih, J., Holets-McCormack, S.R., Gunter, E.W. Clin. Chem. (1999) [Pubmed]
  32. Multilayer fluorescent immunoassay technique. Grenner, G., Inbar, S., Meneghini, F.A., Long, E.W., Yamartino, E.J., Bowen, M.S., Blackwood, J.J., Padilla, A.J., Maretsky, D., Staedter, M. Clin. Chem. (1989) [Pubmed]
  33. Abbott's fluorescence polarization immunoassay for cyclosporine and metabolites compared with the Sandoz "Sandimmune" RIA. Sanghvi, A., Diven, W., Seltman, H., Starzl, T. Clin. Chem. (1988) [Pubmed]
  34. Histone deacetylase inhibitors: the Abbott experience. Curtin, M., Glaser, K. Current medicinal chemistry. (2003) [Pubmed]
  35. Multiple forms of prostate-specific antigen in serum: differences in immunorecognition by monoclonal and polyclonal assays. Zhou, A.M., Tewari, P.C., Bluestein, B.I., Caldwell, G.W., Larsen, F.L. Clin. Chem. (1993) [Pubmed]
  36. Immunofluorescent analysis of estrogen induction of progesterone receptor in the rhesus uterus. Okulicz, W.C., Savasta, A.M., Hoberg, L.M., Longcope, C. Endocrinology (1989) [Pubmed]
  37. Hepatitis C virus infection among patients attending a clinic for sexually transmitted diseases. Weinstock, H.S., Bolan, G., Reingold, A.L., Polish, L.B. JAMA (1993) [Pubmed]
  38. Subtyping of hepatitis B surface antigen and antibody by radioimmunoassay. Hoofnagle, J.H., Gerety, R.J., Smallwood, L.A., Barker, L.F. Gastroenterology (1977) [Pubmed]
  39. Multiparametric study (SAMBA 200) of estrogen receptor immunocytochemical assay in 400 human breast carcinomas: analysis of estrogen receptor distribution heterogeneity in tissues and correlations with dextran coated charcoal assays and morphological data. Charpin, C., Martin, P.M., De Victor, B., Lavaut, M.N., Habib, M.C., Andrac, L., Toga, M. Cancer Res. (1988) [Pubmed]
  40. Risk of liver disease in HCV-seropositive kidney transplant recipients. Rohr, M.S., Lesniewski, R.R., Rubin, C.A., Johnson, R.G., Heise, E.R., McDonald, J.C., Adams, P.L. Ann. Surg. (1993) [Pubmed]
  41. Gene-eluting stents: comparison of adenoviral and adeno- associated viral gene delivery to the blood vessel wall in vivo. Sharif, F., Hynes, S.O., McMahon, J., Cooney, R., Conroy, S., Dockery, P., Duffy, G., Daly, K., Crowley, J., Bartlett, J.S., O'Brien, T. Hum. Gene Ther. (2006) [Pubmed]
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