The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pharmacology, Clinical

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pharmacology, Clinical


Psychiatry related information on Pharmacology, Clinical


High impact information on Pharmacology, Clinical


Chemical compound and disease context of Pharmacology, Clinical


Biological context of Pharmacology, Clinical


Anatomical context of Pharmacology, Clinical


Associations of Pharmacology, Clinical with chemical compounds


Gene context of Pharmacology, Clinical

  • Our studies of combinations of high-dose cyclosporin (CsA) or PSC 833 with etoposide, doxorubicin, or paclitaxel have produced data regarding the role of Pgp in the clinical pharmacology of these agents [31].
  • The authors concluded that they had obtained an analytically valid and clinically reliable bioanalytical method for the determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan, and 3-hydroxymorphinan in human urine for CYP2D6 phenotyping and CYP3A4 activity measurements for clinical pharmacology studies [32].
  • OBJECTIVE: We examined a large database containing results on CYP2D6 and CYP2C19 activity of 4301 Dutch volunteers phenotyped in the context of various clinical pharmacology studies [33].
  • Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor [34].
  • CCR3 antagonists are likely to be safe and effective therapies for allergic diseases, and their clinical pharmacology can readily be defined within phase I/II studies in patients with allergy and asthma [35].

Analytical, diagnostic and therapeutic context of Pharmacology, Clinical


  1. Clinical pharmacology and toxicity of 4'-O-tetrahydropyranyladriamycin. Miller, A.A., Schmidt, C.G. Cancer Res. (1987) [Pubmed]
  2. The clinical pharmacology of bopindolol, a new long-acting beta-adrenoceptor antagonist, in hypertension. van den Meiracker, A.H., Man in 't Veld, A.J., van Eck, H.J., Boomsma, F., Derkx, F.H., Mulder, P., Schalekamp, M.A. Clin. Pharmacol. Ther. (1987) [Pubmed]
  3. Inhibition of thrombus formation by low-dose acetylsalicylic acid, dipyridamole, and their combination in a model of platelet-vessel wall interaction. Müller, T.H. Neurology (2001) [Pubmed]
  4. Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension. McIntyre, M., Caffe, S.E., Michalak, R.A., Reid, J.L. Pharmacol. Ther. (1997) [Pubmed]
  5. Tolerability profile of zolmitriptan (Zomig; 311C90), a novel dual central and peripherally acting 5HT1B/1D agonist. International clinical experience based on > 3000 subjects treated with zolmitriptan. Edmeads, J.G., Millson, D.S. Cephalalgia : an international journal of headache. (1997) [Pubmed]
  6. History and current status of opioid maintenance treatments: blending conference session. Kreek, M.J., Vocci, F.J. Journal of substance abuse treatment. (2002) [Pubmed]
  7. Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides. Yarchoan, R., Mitsuya, H., Myers, C.E., Broder, S. N. Engl. J. Med. (1989) [Pubmed]
  8. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Green, A.R., Mechan, A.O., Elliott, J.M., O'Shea, E., Colado, M.I. Pharmacol. Rev. (2003) [Pubmed]
  9. Clinical pharmacology of the dietary supplement creatine monohydrate. Persky, A.M., Brazeau, G.A. Pharmacol. Rev. (2001) [Pubmed]
  10. Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. Roques, B.P., Noble, F., Daugé, V., Fournié-Zaluski, M.C., Beaumont, A. Pharmacol. Rev. (1993) [Pubmed]
  11. The clinical pharmacology of L-arginine. Böger, R.H., Bode-Böger, S.M. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  12. Current pharmacological treatment approaches to central nervous system leukaemia. Blaney, S.M., Balis, F.M., Poplack, D.G. Drugs (1991) [Pubmed]
  13. Clinical pharmacology of two chloramphenicol preparations in children: sodium succinate (iv) and palmitate (oral) esters. Pickering, L.K., Hoecker, J.L., Kramer, W.G., Kohl, S., Cleary, T.G. J. Pediatr. (1980) [Pubmed]
  14. Clinical pharmacology of carboplatin administered in combination with paclitaxel. van Warmerdam, L.J., Huizing, M.T., Giaccone, G., Postmus, P.E., ten Bokkel Huinink, W.W., van Zandwijk, N., Koolen, M.G., Helmerhorst, T.J., van der Vijgh, W.J., Veenhof, C.H., Beijnen, J.H. Semin. Oncol. (1997) [Pubmed]
  15. Role of anastrozole in adjuvant therapy for postmenopausal patients. Buzdar, A.U. Semin. Oncol. (2003) [Pubmed]
  16. Lack of behavioural toxicity of mizolastine: a review of the clinical pharmacology studies. Rosenzweig, P., Patat, A. Clin. Exp. Allergy (1999) [Pubmed]
  17. Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics. Lin, J.T., Cashmore, A.R., Baker, M., Dreyer, R.N., Ernstoff, M., Marsh, J.C., Bertino, J.R., Whitfield, L.R., Delap, R., Grillo-Lopez, A. Cancer Res. (1987) [Pubmed]
  18. Cocaine: clinical pharmacology and toxicology. Farrar, H.C., Kearns, G.L. J. Pediatr. (1989) [Pubmed]
  19. Magnesium sulphate: a review of clinical pharmacology applied to obstetrics. Duley, L., Farrell, B., Neilson, J.P. British journal of obstetrics and gynaecology. (1999) [Pubmed]
  20. Valdecoxib: a review. Chavez, M.L., DeKorte, C.J. Clinical therapeutics. (2003) [Pubmed]
  21. Linkage between X-chromosome markers and manic-depressive illness. Two Sardinian pedigrees. Del Zompo, M., Bocchetta, A., Goldin, L.R., Corsini, G.U. Acta psychiatrica Scandinavica. (1984) [Pubmed]
  22. The pharmacology of intraperitoneally administered bleomycin. Howell, S.B., Schiefer, M., Andrews, P.A., Markman, M., Abramson, I. J. Clin. Oncol. (1987) [Pubmed]
  23. Experimental and clinical pharmacology of metampicillin in the biliary tract. Brogard, J.M., Pinget, M., Adloff, M., Dorner, M., Lavillaureix, J. J. Antimicrob. Chemother. (1976) [Pubmed]
  24. Overview of FTY720 clinical pharmacokinetics and pharmacology. Kovarik, J.M., Schmouder, R.L., Slade, A.J. Therapeutic drug monitoring. (2004) [Pubmed]
  25. Single-dose treatment of acute cystitis with fosfomycin tromethamine. Stein, G.E. The Annals of pharmacotherapy. (1998) [Pubmed]
  26. The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonists. Thibonnier, M., Coles, P., Thibonnier, A., Shoham, M. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  27. Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: clinical pharmacology and pharmacodynamics. Grochow, L.B., Noe, D.A., Dole, G.B., Rowinsky, E.K., Ettinger, D.S., Graham, M.L., McGuire, W.P., Donehower, R.C. J. Natl. Cancer Inst. (1989) [Pubmed]
  28. Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole. Rigas, J.R., Francis, P.A., Muindi, J.R., Kris, M.G., Huselton, C., DeGrazia, F., Orazem, J.P., Young, C.W., Warrell, R.P. J. Natl. Cancer Inst. (1993) [Pubmed]
  29. Clinical pharmacology of oral and i.v. N-methylformamide: a pharmacologic basis for lack of clinical antineoplastic activity. Rowinsky, E.K., Noe, D.A., Orr, D.W., Grochow, L.B., Ettinger, D.S., Donehower, R.C. J. Natl. Cancer Inst. (1988) [Pubmed]
  30. Congestive heart failure associated with itraconazole. Ahmad, S.R., Singer, S.J., Leissa, B.G. Lancet (2001) [Pubmed]
  31. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Sikic, B.I., Fisher, G.A., Lum, B.L., Halsey, J., Beketic-Oreskovic, L., Chen, G. Cancer Chemother. Pharmacol. (1997) [Pubmed]
  32. Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening. Wieling, J., Tamminga, W.J., Sakiman, E.P., Oosterhuis, B., Wemer, J., Jonkman, J.H. Therapeutic drug monitoring. (2000) [Pubmed]
  33. CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences. Tamminga, W.J., Wemer, J., Oosterhuis, B., Weiling, J., Wilffert, B., de Leij, L.F., de Zeeuw, R.A., Jonkman, J.H. Eur. J. Clin. Pharmacol. (1999) [Pubmed]
  34. Clinical pharmacology of etoricoxib: a novel selective COX2 inhibitor. Patrignani, P., Capone, M.L., Tacconelli, S. Expert opinion on pharmacotherapy. (2003) [Pubmed]
  35. Eotaxin receptor (CCR3) antagonism in asthma and allergic disease. Erin, E.M., Williams, T.J., Barnes, P.J., Hansel, T.T. Current drug targets. Inflammation and allergy. (2002) [Pubmed]
  36. Role of leucovorin dosing and administration schedule. Jolivet, J. Eur. J. Cancer (1995) [Pubmed]
  37. A pharmacokinetic model and the clinical pharmacology of cis-platinum, 5-fluorouracil and mitomycin-C in isolated pelvic perfusion. Wanebo, H.J., Belliveau, J.F. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  38. Clinical pharmacology of oral and intravenous 4-demethoxydaunorubicin. Smith, D.B., Margison, J.M., Lucas, S.B., Wilkinson, P.M., Howell, A. Cancer Chemother. Pharmacol. (1987) [Pubmed]
  39. Clinical experience with iomeprol in myelography and myelo-CT: clinical pharmacology and double-blind comparisons with iopamidol, iohexol, and iotrolan. Katayama, H., Heneine, N., van Gessel, R., Taroni, P., Spinazzi, A. Investigative radiology. (2001) [Pubmed]
  40. The pharmacology of orally administered chemotherapy. A reappraisal. Poplack, D.G., Balis, F.M., Zimm, S. Cancer (1986) [Pubmed]
WikiGenes - Universities