Disease relevance of Antilon

• As expected, there is a linear relationship between the degree of toxicity and the barbiturate level, but much higher barbiturate levels were tolerated without toxicity by subjects taking eterobarb [1].
• Effectiveness of N,N-dimethoxymethyl-phenobarbital (eterobarbital) on febrile seizures [2].

High impact information on Antilon

• Metabolism of dimethoxymethyl phenobarbital (eterobarb) in patients with epilepsy [3].
• A comparison of the toxicity effects of the anticonvulsant eterobarb (antilon, DMMP) and phenobarbital in normal human volunteers [1].
• Comparative pharmacokinetics and pharmacodynamics of eterobarbital and phenobarbital in normal volunteers [4].
• A clinical pharmacology of eterobarb: a gas chromatographic--mass spectrometric study [5].

Associations of Antilon with other chemical compounds

• Five of these new drugs have known mechanisms of action (vigabatrin, lamotrigine, tiagabine, oxcarbazepine and eterobarb), which may provide for a more rational approach to the treatment of epilepsy [6].

Analytical, diagnostic and therapeutic context of Antilon

• The unique and clinically intriguing feature of eterobarb is that while sharing the anticonvulsant properties of other barbiturates, the hypnotic side effects usually associated with barbiturates appear to be absent in animal studies and greatly reduced in clinical trials [1].

References