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Chemical Compound Review:

PubChem13735 but-2-ynedioic acid

Synonyms: NSC-1903, A15207_ALDRICH, AG-D-84070, ACMC-209cog, CHEBI:30781, ...

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Disease relevance of Butynedioic acid

Effects of acetylenedicarboxylate: relationship between decreased carcass lipid and increased liver size and lean body weight [1].

High impact information on Butynedioic acid

Acetylenedicarboxylic acid dimethylester (ADDM): A new inhibitor of oxidative phosphorylation in beef heart mitochondria [2].
The integrated bioelectrodes consisting of NR and CoII-Mb show catalytic activities for NO3- reduction and acetylene-dicarboxylic acid hydrogenation, respectively [3].
Novel heterocyclic systems, tetrazolo[4,5-a][1,7]benzodiazonine inner salt 2 and 3-oxo-3,7-dihydro-2H-pyrazolo[3,4-b]pyridine 5, have been synthesized by the reactions of dimethyl acetylenedicarboxylate with 1 and tetrazolium-5-anilide 4, respectively, and fully characterized by X-ray crystallography [4].
It is therefore plausible that dicyanoacetylene and its hydrolytic product acetylene dicarboxylic acid (ADCA) may have played a role in chemical evolution [5].

References

Effects of acetylenedicarboxylate: relationship between decreased carcass lipid and increased liver size and lean body weight. Arch, J.R., Cornish, S., Green, A., Cawthorne, M.A. International journal of obesity. (1979) [Pubmed]
Acetylenedicarboxylic acid dimethylester (ADDM): A new inhibitor of oxidative phosphorylation in beef heart mitochondria. Bäuerlein, E., Trasch, H. FEBS Lett. (1979) [Pubmed]
Fully integrated biocatalytic electrodes based on bioaffinity interactions. Katz, E., Heleg-Shabtai, V., Bardea, A., Willner, I., Rau, H.K., Haehnel, W. Biosensors & bioelectronics. (1998) [Pubmed]
Reaction cascades initiated by nucleophilic attack of heteropentalene mesomeric betaine and nitrogen-rich mesoionic tetrazolium-5-amides on electron-deficient unsaturated compounds. Synthesis of novel heterocyclic systems. Araki, S., Kuzuya, M., Hamada, K., Nogura, M., Ohata, N. Org. Biomol. Chem. (2003) [Pubmed]
Urea-acetylene dicarboxylic acid reaction: a likely pathway for prebiotic uracil formation. Subbaraman, A.S., Kazi, Z.A., Choughuley, A.S., Chadha, M.S. Orig. Life (1980) [Pubmed]

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