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Chemical Compound Review:

AC1MXCI7 2,3-bis-sulfanylpropane-1- sulfonate

Synonyms: STK386918, AKOS005431561, MolPort-003-708-708, 2,3-disulfanylpropane-1-sulfonate, 2,3-bis(sulfanyl)propane-1-sulfonate

This record was replaced with 6321.

Suzuki, S. et al., Hurlbut, K.M. et al., Zalups, R.K. et al., Chen, W.Y. et al., Reuther, H. et al., et al.

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Disease relevance of DMPS

The therapeutic use of 2,3-dimercaptopropane-1-sulfonate in two cases of inorganic mercury poisoning [1].
Mechanisms of action of 2,3-dimercaptopropane-1-sulfonate and the transport, disposition, and toxicity of inorganic mercury in isolated perfused segments of rabbit proximal tubules [2].
Use of 2,3-dimercaptopropane-1-sulfonate in treatment of lead poisoning in children [3].

High impact information on DMPS

The pharmacokinetics of 2,3-dimercaptopropane-1-sulfonate (DMPS), an effective chelating agent for mercury, were determined in five healthy adults after i.v. administration of 3.0 mg/kg of DMPS [4].
Acute inhibitory effects of mercuric chloride on the activities of several enzymes from rat duodenal mucosa and kidney cortex and the protection provided by 2,3-dimercaptopropane-1-sulfonate (DMPS) were examined [5].
Interactions of the chelating agent 2,3-dimercaptopropane-1-sulfonate with red blood cells in vitro. II. Effects on metalloproteins [6].
Determination of total mercury and methylmercury in human hair by graphite-furnace atomic absorption spectrophotometry using 2,3-dimercaptopropane-1-sulfonate as a complexing agent [7].

Analytical, diagnostic and therapeutic context of DMPS

The increase urinary excretion of mercury after treatment with 2,3-dimercaptopropane-1-sulfonate is reported on a 5-year follow-up [8].

References

The therapeutic use of 2,3-dimercaptopropane-1-sulfonate in two cases of inorganic mercury poisoning. Campbell, J.R., Clarkson, T.W., Omar, M.D. JAMA (1986) [Pubmed]
Mechanisms of action of 2,3-dimercaptopropane-1-sulfonate and the transport, disposition, and toxicity of inorganic mercury in isolated perfused segments of rabbit proximal tubules. Zalups, R.K., Parks, L.D., Cannon, V.T., Barfuss, D.W. Mol. Pharmacol. (1998) [Pubmed]
Use of 2,3-dimercaptopropane-1-sulfonate in treatment of lead poisoning in children. Chisolm, J.J., Thomas, D.J. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers. Hurlbut, K.M., Maiorino, R.M., Mayersohn, M., Dart, R.C., Bruce, D.C., Aposhian, H.V. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
Protective effects of 2,3-dimercaptopropane-1-sulfonate on mercuric chloride-induced acute inhibition of enzymes from rat duodenal mucosa and kidney cortex. Suzuki, S., Takamura, S., Sugiki, K., Imai, M., Niwa, O., Tamatani, R. Toxicology (1994) [Pubmed]
Interactions of the chelating agent 2,3-dimercaptopropane-1-sulfonate with red blood cells in vitro. II. Effects on metalloproteins. Reuther, H., Wildenauer, D.B., Weger, N. Chem. Biol. Interact. (1982) [Pubmed]
Determination of total mercury and methylmercury in human hair by graphite-furnace atomic absorption spectrophotometry using 2,3-dimercaptopropane-1-sulfonate as a complexing agent. Chen, W.Y., Wang, Y.C., Kuo, M.S. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2002) [Pubmed]
Intravenous self-administration of metallic mercury: report of a case with a 5-year follow-up. Torres-Alanís, O., Garza-Ocañas, L., Piñeyro-López, A. J. Toxicol. Clin. Toxicol. (1997) [Pubmed]

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