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MeSH Review

Mercury Poisoning, Nervous System

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Disease relevance of Mercury Poisoning, Nervous System


High impact information on Mercury Poisoning, Nervous System


Chemical compound and disease context of Mercury Poisoning, Nervous System

  • Cerebellar neurons in primary culture were exposed to methylmercury, a well-established neurotoxicant known as a cause of Minamata disease, at 0.1-1.0 microM for up to 72 hours and compared with the neurons undergoing apoptosis induced by withdrawing K+ from the medium [11].
  • We looked at regional cerebellar blood flow in patients with Minamata disease (MD) using technetium-99m ethyl cysteinate dimer (99m-Tc-ECD) [12].
  • 5. Thus, both the composition of the sulfur-containing radical and the steroid moiety are important for protection against inorganic mercury poisoning [13].
  • In order to prove or disprove that industrial waste from the Chisso Factory was the culprit in Minamata disease, a total of ten cats were fed food mixed with industrial waste produced in the acetaldehyde-producing plant [14].
  • Autopsy specimens from the historic cat experiment were recently discovered in a storage area at the Kumamoto University School of Medicine. The specimens were from an experiment prompted by physicians in the Chisso Minamata Plant following the announcement made by the Study Group for Minamata disease [14].

Anatomical context of Mercury Poisoning, Nervous System


Gene context of Mercury Poisoning, Nervous System


  1. Renal tubular dysfunction in Minamata disease. Detection of renal tubular antigen and beta-2-microglobin in the urine. Iesato, K., Wakashin, M., Wakashin, Y., Tojo, S. Ann. Intern. Med. (1977) [Pubmed]
  2. Environmental release of chemicals and reproductive ecology. Bajaj, J.S., Misra, A., Rajalakshmi, M., Madan, R. Environ. Health Perspect. (1993) [Pubmed]
  3. Mercury dispersion from Minamata Bay to the Yatsushiro Sea during 1975-1980. Kudo, A., Miyahara, S. Ecotoxicol. Environ. Saf. (1984) [Pubmed]
  4. Truncal hypesthesia in patients with Minamata disease. Yoshida, Y., Kamitsuchibashi, H., Hamada, R., Kuwano, Y., Mishima, I., Igata, A. Intern. Med. (1992) [Pubmed]
  5. Comparison of heavy metal concentrations in human umbilical cord in 1980 and 1990. Sugiyama, S., Noda, H., Tatsumi, S., Yamaguchi, M., Furutani, A., Yasui, M., Yoshimura, M. Nippon Hoigaku Zasshi (1996) [Pubmed]
  6. The therapeutic use of 2,3-dimercaptopropane-1-sulfonate in two cases of inorganic mercury poisoning. Campbell, J.R., Clarkson, T.W., Omar, M.D. JAMA (1986) [Pubmed]
  7. Environmental distribution, analysis, and toxicity of organometal(loid) compounds. Dopp, E., Hartmann, L.M., Florea, A.M., Rettenmeier, A.W., Hirner, A.V. Crit. Rev. Toxicol. (2004) [Pubmed]
  8. Mercuric oxide poisoning treated with whole-bowel irrigation and chelation therapy. Ly, B.T., Williams, S.R., Clark, R.F. Annals of emergency medicine. (2002) [Pubmed]
  9. Evaluation of genotoxic and cytotoxic potential of thiola (N-2-mercaptopropionylglycine), a medicine used in the treatment of humans contaminated with mercury. Formigli, L.M., Ferrari, I., Grisolia, C.K. Environ. Mol. Mutagen. (2002) [Pubmed]
  10. Widespread neuronal degeneration in rats following oral administration of methylmercury during the postnatal developing phase: a model of fetal-type minamata disease. Sakamoto, M., Wakabayashi, K., Kakita, A., Hitoshi Takahashi, n.u.l.l., Adachi, T., Nakano, A. Brain Res. (1998) [Pubmed]
  11. Methylmercury induces apoptosis of rat cerebellar neurons in primary culture. Kunimoto, M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Cerebellar blood flow in methylmercury poisoning (Minamata disease). Itoh, K., Korogi, Y., Tomiguchi, S., Takahashi, M., Okajima, T., Sato, H. Neuroradiology. (2001) [Pubmed]
  13. The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. Szabo, S., Gagnon, M.J. Gen. Pharmacol. (1983) [Pubmed]
  14. Reappraisal of the historic 1959 cat experiment in Minamata by the Chisso Factory. Eto, K., Yasutake, A., Nakano, A., Akagi, H., Tokunaga, H., Kojima, T. Tohoku J. Exp. Med. (2001) [Pubmed]
  15. Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Akagi, H., Grandjean, P., Takizawa, Y., Weihe, P. Environmental research. (1998) [Pubmed]
  16. Ultrastructural changes of human sural nerves in the neuropathy induced by intrauterine methylmercury poisoning (so-called fetal Minamata disease). Takeuchi, T., Eto, K., Oyanag, S., Miyajima, H. Virchows Archiv. B: Cell pathology. (1978) [Pubmed]
  17. Extracorporeal regional complexing haemodialysis treatment of acute inorganic mercury intoxication. Kostyniak, P.J., Greizerstein, H.B., Goldstein, J., Lachaal, M., Reddy, P., Clarkson, T.W., Walshe, J., Cunningham, E. Human & experimental toxicology. (1990) [Pubmed]
  18. Effects of methylmercury on the brain of infant rats reared artificially. Naruse, I., Arakawa, H., Fukui, Y. Tokushima J. Exp. Med. (1993) [Pubmed]
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