Disease relevance of N-cyclohexylcyclohexanamine

• John's wort, was assayed as a stable dicyclohexylammonium salt (Hyp-DCHA) for cytotoxicity and inhibition of matrix proteinases, tumor invasion, and metastasis [1].

High impact information on N-cyclohexylcyclohexanamine

• Intracellular putrescine and spermidine were sensitive to difluoromethylornithine, dicyclohexylammonium sulfate, and dimethylformamide, a planar, polar solvent which has been reported to "normalize" the transformed phenotype [2].
• Dicyclohexylammonium sulphate inhibited both spermidine synthase and spermine synthase activities in Acetobacteria [3].
• The results also suggest that caution should be used in the interpretation of results obtained from experiments where cell adhesion is blocked using exogenous monosaccharides that are in the form of dicyclohexylammonium salts [4].
• This effect is reserved by dicyclohexylammonium, an inhibitor of spermidine synthase (SPDS) [5].

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