Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Pivalone (8R,9R,10R,11S,13S,17R)-17- [2-(2,2...

Synonyms: JO-1016, LS-118665, JO 1016, AC1L25U4, C26H38O5S, ...

Marks, J.G. et al., Burden, A.D. et al., Wilkinson, S.M. et al., Wilkinson, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TIXOCORTOL PIVALATE

One-hundred and thirty-one cases (4.9%) of corticosteroid hypersensitivity were detected and 119 (90.8%) of these cases were positive to TP [1].
The significance of tixocortol-pivalate-positive patch tests in leg ulcer patients [2].

High impact information on TIXOCORTOL PIVALATE

Among newer allergens, methyldibromoglutaronitrile/phenoxyethanol (cosmetic preservative) caused positive allergic reactions in 2% of the patients; tixocortol-21-pivalate and budesonide (corticosteroids), in 2.0% and 1.1% of the patients, respectively; and ethylene urea/melamine formaldehyde mix (textile resin), in 5% of the patients [3].
Patch tests with Pivalone and a corticosteroid series (all 1% in ethanol) detected all the patients with steroid sensitivity [4].

References

Contact hypersensitivity to topical corticosteroids. Burden, A.D., Beck, M.H. Br. J. Dermatol. (1992) [Pubmed]
The significance of tixocortol-pivalate-positive patch tests in leg ulcer patients. Wilkinson, M., Cartwright, P., English, J.S. Contact Derm. (1990) [Pubmed]
North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. Marks, J.G., Belsito, D.V., DeLeo, V.A., Fowler, J.F., Fransway, A.F., Maibach, H.I., Mathias, C.G., Nethercott, J.R., Rietschel, R.L., Sherertz, E.F., Storrs, F.J., Taylor, J.S. J. Am. Acad. Dermatol. (1998) [Pubmed]
A prospective study into the value of patch and intradermal tests in identifying topical corticosteroid allergy. Wilkinson, S.M., Heagerty, A.H., English, J.S. Br. J. Dermatol. (1992) [Pubmed]

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