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Chemical Compound Review

Feruloyl-CoA     [(2R,3R,4R,5R)-5-(6- aminopurin-9-yl)-4...

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Disease relevance of Feruloyl-CoA

  • The deduced amino acid sequences of fcs exhibited up to 37% amino acid identity to long-chain fatty acid coenzymeA ligases but no significant similarity to the feruloyl-CoA synthetase of Pseudomonas sp. strain HR199 [1].
  • Here, we report on the purification of the recombinant AtCCR1 protein expressed in Escherichia coli and the subsequent determination of its kinetic properties (K(m) and k(cat)/K(m) values) towards its main substrates i.e. feruloyl-CoA, sinapoyl-CoA, and p-coumaroyl-CoA esters [2].

High impact information on Feruloyl-CoA

  • Cell-suspension cultures of Vitis vinifera L. cv Pinot Noir accumulated resveratrol upon fungal elicitation, and the activity of S-adenosyl-L-methionine:trans-caffeoyl-coenzyme A 3-O-methyl-transferase (CCoAOMT), yielding feruloyl-CoA, increased to a transient maximum at 12 to 15 h [3].
  • The feruloyl-CoA synthetase and enoyl-CoA hydratase/aldolase activities of the fcs and ech gene products, respectively, were confirmed by photometric assays and by high-pressure liquid chromatography analysis [4].
  • Furthermore, feruloyl-CoA showed a strong competitive inhibition of the CCR catalysis of other cinnamoyl CoA esters [5].
  • THT follows Michaelis-Menten kinetics in the presence of low concentrations of feruloyl-CoA but negative cooperativity occurs when this concentration increases above 2.5 microM, resulting in a marked decrease of the affinity for tyramine [6].
  • Reduction of feruloyl-CoA to coniferaldehyde catalysed by the reductase is a freely reversible reaction with an equilibrium constant of 5.6 x 10(-4) M at pH 6.25 [7].

Chemical compound and disease context of Feruloyl-CoA


Biological context of Feruloyl-CoA

  • The substrate, feruloyl-CoA, was modelled into the active site based on the structure of enoyl-CoA hydratase bound to the feruloyl-CoA-like substrate 4-(N,N-dimethylamino)-cinnamoyl-CoA (PDB code 1ey3) [9].

Associations of Feruloyl-CoA with other chemical compounds


Gene context of Feruloyl-CoA


Analytical, diagnostic and therapeutic context of Feruloyl-CoA


  1. Identification of Amycolatopsis sp. strain HR167 genes, involved in the bioconversion of ferulic acid to vanillin. Achterholt, S., Priefert, H., Steinbüchel, A. Appl. Microbiol. Biotechnol. (2000) [Pubmed]
  2. Kinetic and inhibition studies of cinnamoyl-CoA reductase 1 from Arabidopsis thaliana. Baltas, M., Lapeyre, C., Bedos-Belval, F., Maturano, M., Saint-Aguet, P., Roussel, L., Duran, H., Grima-Pettenati, J. Plant Physiol. Biochem. (2005) [Pubmed]
  3. Characterization and expression of caffeoyl-coenzyme A 3-O-methyltransferase proposed for the induced resistance response of Vitis vinifera L. Busam, G., Junghanns, K.T., Kneusel, R.E., Kassemeyer, H.H., Matern, U. Plant Physiol. (1997) [Pubmed]
  4. Biochemical and genetic analyses of ferulic acid catabolism in Pseudomonas sp. Strain HR199. Overhage, J., Priefert, H., Steinbüchel, A. Appl. Environ. Microbiol. (1999) [Pubmed]
  5. Clarification of cinnamoyl co-enzyme A reductase catalysis in monolignol biosynthesis of Aspen. Li, L., Cheng, X., Lu, S., Nakatsubo, T., Umezawa, T., Chiang, V.L. Plant Cell Physiol. (2005) [Pubmed]
  6. Purification, characterization and partial amino acid sequencing of hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase from tobacco cell-suspension cultures. Negrel, J., Javelle, F. Eur. J. Biochem. (1997) [Pubmed]
  7. Enzymic synthesis of lignin precursors. Comparison of cinnamoyl-CoA reductase and cinnamyl alcohol:NADP+ dehydrogenase from spruce (Picea abies L.) and soybean (Glycine max L.). Lüderitz, T., Grisebach, H. Eur. J. Biochem. (1981) [Pubmed]
  8. Production of vanillin by metabolically engineered Escherichia coli. Yoon, S.H., Li, C., Kim, J.E., Lee, S.H., Yoon, J.Y., Choi, M.S., Seo, W.T., Yang, J.K., Kim, J.Y., Kim, S.W. Biotechnol. Lett. (2005) [Pubmed]
  9. The 1.8 A resolution structure of hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL) from Pseudomonas fluorescens, an enzyme that catalyses the transformation of feruloyl-coenzyme A to vanillin. Leonard, P.M., Brzozowski, A.M., Lebedev, A., Marshall, C.M., Smith, D.J., Verma, C.S., Walton, N.J., Grogan, G. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  10. Two cinnamoyl-CoA reductase (CCR) genes from Arabidopsis thaliana are differentially expressed during development and in response to infection with pathogenic bacteria. Lauvergeat, V., Lacomme, C., Lacombe, E., Lasserre, E., Roby, D., Grima-Pettenati, J. Phytochemistry (2001) [Pubmed]
  11. Purification, characterization, and immunolocalization of hydroxycinnamoyl-CoA: tyramine N-(hydroxycinnamoyl)transferase from opium poppy. Yu, M., Facchini, P.J. Planta (1999) [Pubmed]
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