Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

C00411 [(2R,3R,4R)-5-(6-aminopurin- 9-yl)-4...

Synonyms:

Schmidt, A. et al., Ma, Q.H. et al., Wengenmayer, H. et al., Yamauchi, K. et al.

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Disease relevance of C00411

Recombinant Ta-CCR2 protein purified from E. coli converted feruloyl CoA, 5-OH-feruloyl CoA, sinapoyl CoA and caffeoyl CoA with almost similar efficiency, suggesting that it is involved in both G and S lignin synthesis [1].

High impact information on C00411

Recombinant THT exhibited a broad substrate specificity, similar to that of native potato THT, accepting cinnamoyl-, 4-coumaroyl-, caffeoyl-, feruloyl- and sinapoyl-CoA as acyl donors and tyramine, octopamine, and noradrenalin as acceptors tested [2].
These results indicate that robinia and oleander have a pathway that produces sinapyl alcohol from sinapic acid via sinapoyl-CoA [3].
Feruloyl-CoA was the substrate with the lowest Km value (73 muM) and highest V (230 nkat/mg) followed by 5-hydroxy-feruloyl-CoA, sinapoyl-CoA, p-coumaroyl-CoA, caffeoyl-CoA and cinnamoyl-CoA [4].

References

Biochemical characterization of a cinnamoyl-CoA reductase from wheat. Ma, Q.H., Tian, B. Biol. Chem. (2005) [Pubmed]
Cloning and expression of a potato cDNA encoding hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase. Schmidt, A., Grimm, R., Schmidt, J., Scheel, D., Strack, D., Rosahl, S. J. Biol. Chem. (1999) [Pubmed]
Multiform biosynthetic pathway of syringyl lignin in angiosperms. Yamauchi, K., Yasuda, S., Hamada, K., Tsutsumi, Y., Fukushima, K. Planta (2003) [Pubmed]
Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax). Wengenmayer, H., Ebel, J., Grisebach, H. Eur. J. Biochem. (1976) [Pubmed]

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