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Chemical Compound Review

AG-F-85019     4-(3-hydroxyprop-1-enyl)-2,6- dimethoxy-phenol

Synonyms: SureCN1457517, ACMC-20ajpw, CTK4J8695, AC1L97VK, 4-(3-hydroxyprop-1-enyl)-2,6-dimethoxyphenol
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High impact information on Sinapoyl alcohol


Biological context of Sinapoyl alcohol

  • Docking of p-coumaryl, coniferyl and sinapyl alcohol in the substrate binding site of ATP A2 were analysed on the basis of the crystal structure of a horseradish peroxidase C-CN-ferulic acid complex [5].
  • Taken together, the aromatic ring-modifying reactions (the conversion from guaiacyl to syringyl moiety, including the hydroxylation and methylation) were more important for the regulation of the sinapyl alcohol biosynthesis than the reducing reactions (the reduction of acids to alcohols) in the differentiating xylem [6].

Associations of Sinapoyl alcohol with other chemical compounds


Gene context of Sinapoyl alcohol

  • Consistent with these observations, the expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was reduced by sinapyl alcohol in a concentration-dependent manner [8].
  • The analysis indicates that the precursors p-coumaryl and coniferyl alcohols are preferred by ATP A2, while the oxidation of sinapyl alcohol will be sterically hindered in ATP A2 as well as in all other plant peroxidases due to an overlap with the conserved Pro-139 [5].
  • The ZPO-C:6xHis protein had a peroxidase activity preferring sinapyl alcohol as well as coniferyl alcohol as a substrate, with a narrow pH optimum around 5.25 [9].


  1. Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis. Kim, S.J., Kim, M.R., Bedgar, D.L., Moinuddin, S.G., Cardenas, C.L., Davin, L.B., Kang, C., Lewis, N.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Profiling of oligolignols reveals monolignol coupling conditions in lignifying poplar xylem. Morreel, K., Ralph, J., Kim, H., Lu, F., Goeminne, G., Ralph, S., Messens, E., Boerjan, W. Plant Physiol. (2004) [Pubmed]
  3. The cationic cell-wall-peroxidase having oxidation ability for polymeric substrate participates in the late stage of lignification of Populus alba L. Sasaki, S., Baba, K., Nishida, T., Tsutsumi, Y., Kondo, R. Plant Mol. Biol. (2006) [Pubmed]
  4. Multiform biosynthetic pathway of syringyl lignin in angiosperms. Yamauchi, K., Yasuda, S., Hamada, K., Tsutsumi, Y., Fukushima, K. Planta (2003) [Pubmed]
  5. Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification. Ostergaard, L., Teilum, K., Mirza, O., Mattsson, O., Petersen, M., Welinder, K.G., Mundy, J., Gajhede, M., Henriksen, A. Plant Mol. Biol. (2000) [Pubmed]
  6. The regulation from guaiacyl to syringyl lignin in the differentiating xylem of Robinia pseudoacacia. Yamauchi, K., Fukushima, K. C. R. Biol. (2004) [Pubmed]
  7. Monolignol oxidation by xylem peroxidase isoforms of Norway spruce (Picea abies) and silver birch (Betula pendula). Marjamaa, K., Kukkola, E., Lundell, T., Karhunen, P., Saranpää, P., Fagerstedt, K.V. Tree Physiol. (2006) [Pubmed]
  8. Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin. Choi, J., Shin, K.M., Park, H.J., Jung, H.J., Kim, H.J., Lee, Y.S., Rew, J.H., Lee, K.T. Planta Med. (2004) [Pubmed]
  9. Isolation and Characterization of a Novel Peroxidase Gene ZPO-C Whose Expression and Function are Closely Associated with Lignification during Tracheary Element Differentiation. Sato, Y., Demura, T., Yamawaki, K., Inoue, Y., Sato, S., Sugiyama, M., Fukuda, H. Plant Cell Physiol. (2006) [Pubmed]
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