Disease relevance of C01207

• It was found that Danshensu could protect the mitochondrial membrane from the ischemia-reperfusion injury and lipid peroxidation [1].

High impact information on C01207

• It has been demonstrated that salvianolic acid B and danshensu are the major components among the eight commercial Fufang Danshen products studied [2].
• A simple HPLC method with photodiode-array (PDA) ultraviolet detection was developed for the simultaneous determination of three major lipophilic components (cryptotanshinone, tanshinone I and tanshinone IIA) and three major hydrophilic components (danshensu, protocatechuic aldehyde and salvianolic acid B) of Danshen (Salvia miltiorrhiza) [2].
• The electrospray ionization (ESI) MS-MS spectra of most salvianolic acids displayed a characteristic behavior of loss of danshensu and caffeic acid moieties, while those of tanshinones showed a particular behavior of loss of H2O which is quite different from the fragmentation pattern in electron ionization mass spectrometry (EI-MS) [3].
• Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels [4].
• In 5-HT-primed preparations, the CaCl(2)-induced vasoconstriction was abolished by 2 mg/ml danshen aqueous extract and 200 mug/ml danshensu, whereas, in KCl-primed preparations, 10 mg/ml danshen aqueous extract and 600 mug/ml danshensu were required to abrogate the vasoconstriction [4].

Biological context of C01207

• The pharmacokinetics of Danshensu in rabbits was evaluated by the HPLC method for plasma Danshensu [5].

Anatomical context of C01207

• The danshen aqueous extract was 13 times less potent than danshensu in relaxing 5-HT-precontracted coronary artery rings; IC(50) values were 930.3+/-133.5 mug/ml and 71.5+/-11.0 mug/ml [4].
• These findings suggest the vasorelaxant actions of danshen aqueous extract and danshensu were produced by inhibition of Ca(2+) influx in the vascular smooth muscle cells [4].

Associations of C01207 with other chemical compounds

• In this study, we have investigated the actions of danshensu, an active, water-extractable component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 muM 5-hydroxytryptamine (5-HT) and its action compared to the water-extractable fraction of the herb [4].

Gene context of C01207

• An active component Danshensu (DS) of CDDP was separated by reversed-phase high performance liquid chromatography using column-switching system and analyzed by electrospray mass spectrometry [6].
• Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone HA, and cryptotanshinone were determined [7].

Analytical, diagnostic and therapeutic context of C01207

• Determination of Danshensu, a major active compound of Radix Salvia miltiorrhiza in dog plasma by HPLC with fluorescence detection [8].
• A simple and sensitive high performance liquid chromatography method has been developed for the determination of Danshensu (3, 4-dihydroxyphenyllactic acid) in dog plasma [8].
• This validated assay was applied to the determination of Danshensu concentration in dog plasma after oral administration of Radix Salvia miltiorrhiza extracts [8].

References