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Chemical Compound Review

AGN-PC-00CF31     3-(3,4-dihydroxyphenyl)-2- hydroxy...

Synonyms: SureCN829784, AG-E-66709, CHEBI:17807, HMDB03503, CTK1A5625, ...
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Disease relevance of C01207


High impact information on C01207

  • It has been demonstrated that salvianolic acid B and danshensu are the major components among the eight commercial Fufang Danshen products studied [2].
  • A simple HPLC method with photodiode-array (PDA) ultraviolet detection was developed for the simultaneous determination of three major lipophilic components (cryptotanshinone, tanshinone I and tanshinone IIA) and three major hydrophilic components (danshensu, protocatechuic aldehyde and salvianolic acid B) of Danshen (Salvia miltiorrhiza) [2].
  • The electrospray ionization (ESI) MS-MS spectra of most salvianolic acids displayed a characteristic behavior of loss of danshensu and caffeic acid moieties, while those of tanshinones showed a particular behavior of loss of H2O which is quite different from the fragmentation pattern in electron ionization mass spectrometry (EI-MS) [3].
  • Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels [4].
  • In 5-HT-primed preparations, the CaCl(2)-induced vasoconstriction was abolished by 2 mg/ml danshen aqueous extract and 200 mug/ml danshensu, whereas, in KCl-primed preparations, 10 mg/ml danshen aqueous extract and 600 mug/ml danshensu were required to abrogate the vasoconstriction [4].

Biological context of C01207


Anatomical context of C01207


Associations of C01207 with other chemical compounds

  • In this study, we have investigated the actions of danshensu, an active, water-extractable component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 muM 5-hydroxytryptamine (5-HT) and its action compared to the water-extractable fraction of the herb [4].

Gene context of C01207

  • An active component Danshensu (DS) of CDDP was separated by reversed-phase high performance liquid chromatography using column-switching system and analyzed by electrospray mass spectrometry [6].
  • Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone HA, and cryptotanshinone were determined [7].

Analytical, diagnostic and therapeutic context of C01207


  1. Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Zhao, B.L., Jiang, W., Zhao, Y., Hou, J.W., Xin, W.J. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  2. Improved quality control method for Danshen products--consideration of both hydrophilic and lipophilic active components. Zhou, L., Chow, M., Zuo, Z. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  3. Multi-component HPLC fingerprinting of Radix Salviae Miltiorrhizae and its LC-MS-MS identification. Hu, P., Liang, Q.L., Luo, G.A., Zhao, Z.Z., Jiang, Z.H. Chem. Pharm. Bull. (2005) [Pubmed]
  4. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Lam, F.F., Yeung, J.H., Chan, K.M., Mei Yu Or, P. Vascul. Pharmacol. (2007) [Pubmed]
  5. Pharmacokinetics of a Chinese traditional medicine, danshensu (3,4-dihydroxyphenyllactic acid), in rabbits using high-performance liquid chromatography. Zhao, F.Q., Zheng, N.X., Sato, H., Adachi, I., Horikoshi, I. Biol. Pharm. Bull. (1997) [Pubmed]
  6. Study of the determination and pharmacokinetics of Compound Danshen Dripping Pills in human serum by column switching liquid chromatography electrospray ion trap mass spectrometry. Pei, W.J., Zhao, X.F., Zhu, Z.M., Lin, C.Z., Zhao, W.M., Zheng, X.H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  7. Contents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza). Zhang, H., Yu, C., Jia, J.Y., Leung, S.W., Siow, Y.L., Man, R.Y., Zhu, D.Y. Acta Pharmacol. Sin. (2002) [Pubmed]
  8. Determination of Danshensu, a major active compound of Radix Salvia miltiorrhiza in dog plasma by HPLC with fluorescence detection. Luo, X., Bi, K., Zhou, S., Wei, Q., Zhang, R. Biomed. Chromatogr. (2001) [Pubmed]
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