Disease relevance of Salvianolic acid A

• Salvianolic acid B improves motor function after cerebral ischemia in rats [1].
• Salvianolic acid B (10 mg/kg) also improved the integrity of microvessels after ischemia [1].
• Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B [2].
• Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice [3].

High impact information on Salvianolic acid A

• Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-alpha (TNF-alpha)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species [4].
• Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells [5].
• 3,4-Dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde were purified from 100mg water extracted crude sample of Salvia miltiorrhiza Bunge at purity of 97.6%, 94.2% and 98.2% and at yield of 98.6%, 73.6% and 90.2% [6].
• One-step separation and purification of 3,4-dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography [6].
• Activation of the iberiotoxin-sensitive BK(Ca) channels by salvianolic acid B of the porcine coronary artery smooth muscle cells [7].

Biological context of Salvianolic acid A

• In 5-HT-primed preparations, 2 mg/ml danshen aqueous extract and 0.72 mg/ml salvianolic acid B abolished the CaCl(2)-induced vasoconstriction, whereas, in KCl-primed preparations, 10 mg/ml danshen aqueous extract and 1.44 mg/ml salvianolic acid B produced 90% inhibition [8].
• However, salvianolic acid B, an activate component of SME did not inhibit NF-kappaB transcriptional activity and IkappaB phosphorylation/degradation in IEC-18 cells [9].
• These results suggest that the treatment with salvianolic acid B-rich fraction of SM induces apoptosis in neointima which in turn may help prevent the neointimal thickening [10].
• This method is suitable for determining salvianolic acid B in plasma and thus investigating the pharmacokinetics of salvianolic acid B. Copyright (c) 2007 John Wiley & Sons, Ltd [11].
• Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells [12].

Anatomical context of Salvianolic acid A

• Crude extract of Salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line [13].
• Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels [8].
• Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Abeta(25-35)-induced reduction in BPRP in PC12 cells [14].
• Salvianolic acid B attenuates plasminogen activator inhibitor type 1 production in TNF-alpha treated human umbilical vein endothelial cells [15].
• These findings suggest the vasorelaxant effects of danshen aqueous extract and salvianolic acid B were produced by inhibition of Ca(2+) influx in the vascular smooth muscle cells [8].

Associations of Salvianolic acid A with other chemical compounds

• A new depside named salvianolic acid I was isolated from the aqueous extract of SALVIA CAVALERIEI, along with salvianolic acids A, B, C, H, isosalvianolic acid C, lithospermic acid, and rosmarinic acid [16].
• In conclusion, our results suggest that salvianolic acid B, a major hydrophilic constituent found in Radix S. miltiorrhiza, activated the opening of the BK(Ca) channels of the porcine coronary artery smooth muscle cells through the activation of guanylate cyclase without the involvement of the nitric oxide synthase activation [7].
• The pharmacologically active marker compounds salvianolic acid B, rosmarinic acid, and tanshinone IIA in herbal medicine were quantitatively determined using reverse-phase HPLC techniques [17].
• It has been demonstrated that salvianolic acid B and danshensu are the major components among the eight commercial Fufang Danshen products studied [18].
• The water and MeOH extracts of S. deserta showed strong aldose reductase (AR) inhibitory activity, and their active constituents were determined to be polar compounds different from "tanshinones" of S. miltiorhiza, i.e., lithospermic acid B (1), salvianolic acid K (2), salviaflaside (3), and rosmarinic acid (4) (IC50, 2.63-3.91 microM) [19].

Gene context of Salvianolic acid A

• Effect of salvianolic acid B on Smad3 expression in hepatic stellate cells [20].
• Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells [9].
• Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells [21].
• Salvianolic acid B could markedly inhibit the VEGF-induced hyperpermeability in BAECs (P < 0.01) [22].
• Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells [23].

Analytical, diagnostic and therapeutic context of Salvianolic acid A

• In vivo recoveries of microdialysis probes of salvianolic acid B in rat blood and bile averaged 22 +/- 2% and 41 +/- 1%, respectively [24].
• Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatography [24].
• HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract [25].
• A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model [10].

References