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Chemical Compound Review

SureCN10041475     3-(3,4-dihydroxyphenyl)-2- [(E)-3-[2-[(E)-2...

Synonyms: AC-20308, AKOS015965219, FT-0674511, AC1O1L81, Salvianolicacid A
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Disease relevance of Salvianolic acid A


High impact information on Salvianolic acid A


Biological context of Salvianolic acid A


Anatomical context of Salvianolic acid A


Associations of Salvianolic acid A with other chemical compounds


Gene context of Salvianolic acid A


Analytical, diagnostic and therapeutic context of Salvianolic acid A


  1. Salvianolic acid B improves motor function after cerebral ischemia in rats. Tang, M., Feng, W., Zhang, Y., Zhong, J., Zhang, J. Behavioural pharmacology. (2006) [Pubmed]
  2. Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B. Liu, P., Hu, Y.Y., Liu, C., Zhu, D.Y., Xue, H.M., Xu, Z.Q., Xu, L.M., Liu, C.H., Gu, H.T., Zhang, Z.Q. World J. Gastroenterol. (2002) [Pubmed]
  3. Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice. Du, G.H., Qiu, Y., Zhang, J.T. Journal of Asian natural products research. (2000) [Pubmed]
  4. Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-alpha (TNF-alpha)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species. Zhang, H.S., Wang, S.Q. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  5. Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells. Lin, S.J., Lee, I.T., Chen, Y.H., Lin, F.Y., Sheu, L.M., Ku, H.H., Shiao, M.S., Chen, J.W., Chen, Y.L. J. Cell. Biochem. (2007) [Pubmed]
  6. One-step separation and purification of 3,4-dihydroxyphenyllactic acid, salvianolic acid B and protocatechualdehyde from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography. Gu, M., Wang, X., Su, Z., Ouyang, F. Journal of chromatography. A (2007) [Pubmed]
  7. Activation of the iberiotoxin-sensitive BK(Ca) channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. Lam, F.F., Seto, S.W., Kwan, Y.W., Yeung, J.H., Chan, P. Eur. J. Pharmacol. (2006) [Pubmed]
  8. Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels. Lam, F.F., Yeung, J.H., Kwan, Y.W., Chan, K.M., Or, P.M. Eur. J. Pharmacol. (2006) [Pubmed]
  9. Salvia miltiorrhiza water-soluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells. Kim, J.S., Narula, A.S., Jobin, C. Clin. Exp. Immunol. (2005) [Pubmed]
  10. A salvianolic acid B-rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model. Hung, H.H., Chen, Y.L., Lin, S.J., Yang, S.P., Shih, C.C., Shiao, M.S., Chang, C.H. Histol. Histopathol. (2001) [Pubmed]
  11. A solid-phase extraction method for high-performance liquid chromatographic determination of salvianolic acid B in rabbit plasma: application to pharmacokinetic study. Ma, Y., Wang, T. Biomed. Chromatogr. (2007) [Pubmed]
  12. Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells. Shi, C.S., Huang, H.C., Wu, H.L., Kuo, C.H., Chang, B.I., Shiao, M.S., Shi, G.Y. Thromb. Res. (2007) [Pubmed]
  13. Crude extract of Salvia miltiorrhiza and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line. Lay, I.S., Chiu, J.H., Shiao, M.S., Lui, W.Y., Wu, C.W. Planta Med. (2003) [Pubmed]
  14. Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents Abeta(25-35)-induced reduction in BPRP in PC12 cells. Lin, Y.H., Liu, A.H., Wu, H.L., Westenbroek, C., Song, Q.L., Yu, H.M., Ter Horst, G.J., Li, X.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  15. Salvianolic acid B attenuates plasminogen activator inhibitor type 1 production in TNF-alpha treated human umbilical vein endothelial cells. Zhou, Z., Liu, Y., Miao, A.D., Wang, S.Q. J. Cell. Biochem. (2005) [Pubmed]
  16. Salvianolic Acid I: A New Depside from Salvia cavaleriei. Zhang, H.J., Li, L.N. Planta Med. (1994) [Pubmed]
  17. Quality assessment of radix salviae miltiorrhizae. Hu, P., Luo, G.A., Zhao, Z., Jiang, Z.H. Chem. Pharm. Bull. (2005) [Pubmed]
  18. Improved quality control method for Danshen products--consideration of both hydrophilic and lipophilic active components. Zhou, L., Chow, M., Zuo, Z. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  19. Comparative study of seventeen Salvia plants: aldose reductase inhibitory activity of water and MeOH extracts and liquid chromatography-mass spectrometry (LC-MS) analysis of water extracts. Kasimu, R., Tanaka, K., Tezuka, Y., Gong, Z.N., Li, J.X., Basnet, P., Namba, T., Kadota, S. Chem. Pharm. Bull. (1998) [Pubmed]
  20. Effect of salvianolic acid B on Smad3 expression in hepatic stellate cells. Zhao, J.F., Liu, C.H., Hu, Y.Y., Xu, L.M., Liu, P., Liu, C. HBPD INT (2004) [Pubmed]
  21. Prostate apoptosis response-4 involved in the protective effect of salvianolic acid B against amyloid beta peptide-induced damage in PC12 cells. Tang, M., Zhang, J. Jpn. J. Pharmacol. (2002) [Pubmed]
  22. VEGF induced hyperpermeability in bovine aortic endothelial cell and inhibitory effect of salvianolic acid B. Qui, Y., Rui, Y.C., Zhang, L., Li, T.J., Zhang, W.D. Acta Pharmacol. Sin. (2001) [Pubmed]
  23. Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells. Liu, P., Liu, C.H., Wang, H.N., Hu, Y.Y., Liu, C. Acta Pharmacol. Sin. (2002) [Pubmed]
  24. Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatography. Chen, Y.F., Jaw, I., Shiao, M.S., Tsai, T.H. Journal of chromatography. A. (2005) [Pubmed]
  25. HPLC determination and pharmacokinetic studies of salvianolic acid B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract. Zhang, J., Yu, H., Sheng, Y., Li, L., Ye, M., Guo, D. Biomed. Chromatogr. (2005) [Pubmed]
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