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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00HR4K     10,13-dimethyl- 1,2,4,5,6,7,8,9,11,12,14,15...

Synonyms: ACMC-1B99G, AG-D-40674, CTK4B0654, AKOS004900538, AC1L97NH, ...
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Disease relevance of C01876

  • We describe the cloning, sequencing, and overexpression of the steroid isomerase (3-oxosteroid delta 5-delta 4-isomerase, EC gene of Pseudomonas testosteroni [1].

High impact information on C01876

  • The permeability of bacterial outer membranes was assayed by coupling the influx of highly hydrophobic probes, 3-oxosteroids, with their subsequent oxidation catalysed by 3-oxosteroid delta 1-dehydrogenase, expressed from a gene cloned from Pseudomonas testosteroni [2].
  • Lipid requirement of membrane-bound 3-oxosteroid delta4-delta5-isomerase. Studies on beef adrenocortical microsomes [3].
  • Homology search revealed that the putative product encoded by ORF3 has high level of similarity with the 3-oxosteroid dehydrogenases from A. simplex and P. testosteroni (90% identity in their putative active sites) [4].
  • Isolated hepatocytes rapidly reduced the 3-oxosteroid to the corresponding 3 alpha-hydroxysteroid, which was more rapidly sulphated than the incubated 3 alpha-androstanediol [5].
  • Alkaline-earth ions (Mg2+, Ca2+ and Sr2+) have two specific effects on the kinetic parameters of the beef adrenal 3-oxosteroid delta4-delta5-isomerase activity in the microsomes and in the particles obtained after disrupting the membrane structure by action of 1 M MgCl2 [6].


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