Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-001T4N (hydroxy-(3,7,11,15- tetramethylhexadec-2...

Synonyms: AC1L99Q9

Keller, Y. et al., Collakova, E. et al., Helfrich, M. et al., Ischebeck, T. et al., Scheumann, V. et al.

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Disease relevance of C05427

Geranylgeranyl reductase expressed in Escherichia coli sequentially catalyzes the reduction of geranylgeranyl-chlorophyll a into phytyl-chlorophyll a as well as the reduction of free geranylgeranyl diphosphate into phytyl diphosphate [1].

High impact information on C05427

Phytol is phosphorylated to phytyl-phosphate and phytyl-diphosphate by two successive kinase activities associated with chloroplast envelope membranes of Arabidopsis [2].
The committed step in tocopherol biosynthesis involves condensation of homogentisic acid and phytyl diphosphate (PDP) catalyzed by a membrane-bound homogentisate phytyltransferase (HPT) [3].
The reaction proceeded likewise before esterification and after esterification with phytyl diphosphate [4].
Chlorophyll synthetase catalyzes the last step of chlorophyll biosynthesis, namely prenylation (esterification) of chlorophyllide with phytyl diphosphate or geranylgeranyl diphosphate [5].

References

Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase. Keller, Y., Bouvier, F., d'Harlingue, A., Camara, B. Eur. J. Biochem. (1998) [Pubmed]
A salvage pathway for phytol metabolism in Arabidopsis. Ischebeck, T., Zbierzak, A.M., Kanwischer, M., Dörmann, P. J. Biol. Chem. (2006) [Pubmed]
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis. Collakova, E., DellaPenna, D. Plant Physiol. (2001) [Pubmed]
Substrate specificity of chlorophyll(ide) b reductase in etioplasts of barley (Hordeum vulgare L.). Scheumann, V., Ito, H., Tanaka, A., Schoch, S., Rüdiger, W. Eur. J. Biochem. (1996) [Pubmed]
Chlorophyll synthetase cannot synthesize chlorophyll a'. Helfrich, M., Schoch, S., Lempert, U., Cmiel, E., Rüdiger, W. Eur. J. Biochem. (1994) [Pubmed]

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