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Chemical Compound Review:

CHEMBL1235872 (2R,3R,4S,5R,6R)-2- [(2S,3S,4R,5R)-3,4...

Synonyms: CHEBI:45560, AC1L9FZD, LS-187097, SCR, Sucrose octasulfate

Arunkumar, A.I. et al., Hung, K.W. et al., Chi, Y. et al.

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High impact information on Sucrose octasulfate

Binding of SOS to hFGF-1 is found to induce a subtle conformational change in the protein [1].
SOS binding sites in the D2 domain have been mapped on the basis of the 1H-15N chemical shift perturbation data [2].
To gain insight into the mechanism of activation of the receptor by FGFs, in the present study we investigate the effect(s) of interaction of a heparin analog, sucrose octasulfate (SOS), on the structure, stability, and biological activities of a recombinant acidic FGF from Notophthalmus viridescens (nFGF-1) [3].
In its monomeric state (complexed to SOS), n-FGF-1 shows significant cell proliferation activity [3].

Gene context of Sucrose octasulfate

Binding of SOS to either the D2 domain or hFGF-1 does not seem to be the driving force for the formation of the D2-hFGF-1 binary complex [2].

Analytical, diagnostic and therapeutic context of Sucrose octasulfate

Titration experiments with SOS reveals that the ligand binds specifically to the C-terminal domain of the protein in a 1:1 ratio [1].
Using a variety of techniques such as size-exclusion chromatography, sedimentation velocity, and multidimensional nuclear magnetic resonance (NMR) spectroscopy, it is shown that binding of SOS to nFGF-1 retains the protein in its monomeric state [3].

References

15N NMR relaxation studies of free and ligand-bound human acidic fibroblast growth factor. Chi, Y., Kumar, T.K., Chiu, I.M., Yu, C. J. Biol. Chem. (2000) [Pubmed]
Solution structure of the ligand binding domain of the fibroblast growth factor receptor: role of heparin in the activation of the receptor. Hung, K.W., Kumar, T.K., Kathir, K.M., Xu, P., Ni, F., Ji, H.H., Chen, M.C., Yang, C.C., Lin, F.P., Chiu, I.M., Yu, C. Biochemistry (2005) [Pubmed]
Oligomerization of acidic fibroblast growth factor is not a prerequisite for its cell proliferation activity. Arunkumar, A.I., Kumar, T.K., Kathir, K.M., Srisailam, S., Wang, H.M., Leena, P.S., Chi, Y.H., Chen, H.C., Wu, C.H., Wu, R.T., Chang, G.G., Chiu, I.M., Yu, C. Protein Sci. (2002) [Pubmed]

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