Disease relevance of Notophthalmus

• Cyclophosphamide-induced leukopenia and suppression of limb regeneration in the adult newt, notophthalmus viridescens [1].

High impact information on Notophthalmus

• We investigated the expression of the RAR in the adult newt, Notophthalmus viridescens, whose amputated limbs are capable of regenerating and upon which retinoic acid can act to alter pattern [2].
• Cultured newt (Notophthalmus viridescens) limb cells were transfected by nuclear microinjection of plasmids which provided RA-sensitive reporter activity that could be normalized for differences in cell recovery and transfection efficiency [3].
• To further define its role in the regenerative process, we have examined the pattern of distribution and spatiotemporal expression of two key components, C3 and C5, during limb and lens regeneration in the newt Notophthalmus viridescens [4].
• Structure and stability of an acidic fibroblast growth factor from Notophthalmus viridescens [5].
• C3 was expressed in the dedifferentiated regeneration blastema and in the redifferentiated limb tissues in the axolotl, Amblystoma mexicanum, and in Notophthalmus viridescens [6].

Biological context of Notophthalmus

• It has been suggested (Yorke and Dickson 1984) that myeloid bodies (MBs) in the retinal pigment epithelium (RPE) of the newt, Notophthalmus viridescens, may represent areas of endoplasmic reticulum where lipids, such as 11-cis retinal derived from phagocytized outer segment tips, accumulate prior to esterification [7].
• Using six species of North American amphibian larvae (Rana sylvatica, R. pipiens, R. clamitans, R. catesbeiana, Bufo americanus, and Hyla versicolor), I examined the impact of a globally common herbicide (Roundup) on the survival of tadpoles for 16 days with and without the chemical cues emitted by predatory newts (Notophthalmus viridescens) [8].
• We report the nucleotide sequences of two fibroblast growth factor receptor (FGFR) cDNAs, FGFR1 and FGFR3, from the newt species Notophthalmus viridescens [9].
• 1. Extracts of the dermis of the adult newt, Notophthalmus viridescens, contain hemagglutination activity which is specifically inhibited by N-acetylglucosamine [10].
• We report the sequence of two newt (Notophthalmus viridescens) FGFR2 cDNAs which were isolated from a forelimb blastema cDNA library and represent the newt cognates of two different isoforms of FGFR2, one homologous to bek the other to the KGFR [11].

Anatomical context of Notophthalmus

• The effects of varying doses of retinoic acid on forelimb regeneration in larval Ambystoma mexicanum amputated through the wrist joint and in adult Notophthalmus viridescens amputated through the basal carpals were compared [12].
• Here, we investigated the role of retinoic acid (RA) and one of its receptors, RARbeta, in the reciprocal neurotropic interactions between regenerating limb blastemas and spinal cord explants from the adult newt Notophthalmus viridescens [13].
• We have previously shown, by in situ hybridization, that fibroblast growth factor receptor 2 (FGFR2) is present in the basal layer of wound epithelium during limb regeneration in newts (Notophthalmus viridescens) [14].
• Hox C6 expression during development and regeneration of forelimbs in larval Notophthalmus viridescens [15].
• Catecholamines and adenosine have a stimulating effect on the process of dedifferentiation of cultured iris epithelial cells (IECs) from the adult newt Notophthalmus viridescens [16].

Associations of Notophthalmus with chemical compounds

• To gain insight into the mechanism of activation of the receptor by FGFs, in the present study we investigate the effect(s) of interaction of a heparin analog, sucrose octasulfate (SOS), on the structure, stability, and biological activities of a recombinant acidic FGF from Notophthalmus viridescens (nFGF-1) [17].
• alpha-, beta- and gamma-Crystallins in the regenerating lens of Notophthalmus viridescens [18].
• The antitumor drug 3-nitrobenzothiazolo(3,2-a)quinolinium chloride (NBQ): effects on lens regeneration and interaction with DNA of Notophthalmus viridescens [19].
• The antitumor drug 3-nitrobenzothiazolo [3,2-a] quinolinium chloride (NBQ) stimulates the in vivo lens regeneration in the adult newt Notophthalmus viridescens and induces a differentiated state in HL-60 leukemia cells [20].
• A search for immunoreactive substance P and other neural peptides in the limb regenerate of the newt Notophthalmus viridescens [21].

Gene context of Notophthalmus

• In this report, we describe the isolation and characterization of an FGF-1 molecule from the newt, Notophthalmus viridescens [22].
• Pieces of glass coverslip coated with human fibronectin or human fibrinogen were implanted under one margin of a skin wound on adult newt (Notophthalmus viridescens) hind limbs [23].
• PURPOSE: To determine the expression pattern of Prox 1 during the process of lens regeneration in the urodele Notophthalmus viridescens [24].
• Results of previous research have led to the suggestion that homeobox containing genes are "re-expressed" during the epimorphic regeneration of forelimbs of adult Notophthalmus viridescens in patterns which retrace larval limb development [15].
• Delayed carpal ossification in Notophthalmus viridescens Efts: Relation to the progress of mesopodial completion in newt forelimb regenerates [25].

Analytical, diagnostic and therapeutic context of Notophthalmus

• Effects of hypophysectomy and prolactin on calcium regulation in the red-spotted newt, Notophthalmus viridescens [26].

References