The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

D-FddC     4-amino-5-fluoro-1-[(2R,5S)- 5...

Synonyms: beta-D-FddC, CHEMBL89498, SureCN396634, AG-D-21882, beta-D-5-F-ddC, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of D-FddC

  • While neither compounds is a potent as ddC or 5-F-ddC (2b), 10b gives complete protection against the cytopathic effects of HIV in both host cell lines [1].
  • The rank-order of this ratio was ddC > 5-F-ddC >> ddA > ddI > ddG > beta-F-ddC > beta-F-ddA > beta-F-ddG with the highest ratios indicating the greatest potential for delayed toxicity [2].

High impact information on D-FddC


  1. Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines. Siddiqui, M.A., Driscoll, J.S., Marquez, V.E., Roth, J.S., Shirasaka, T., Mitsuya, H., Barchi, J.J., Kelley, J.A. J. Med. Chem. (1992) [Pubmed]
  2. Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production. Tsai, C.H., Doong, S.L., Johns, D.G., Driscoll, J.S., Cheng, Y.C. Biochem. Pharmacol. (1994) [Pubmed]
  3. Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity. Cui, L., Schinazi, R.F., Gosselin, G., Imbach, J.L., Chu, C.K., Rando, R.F., Revankar, G.R., Sommadossi, J.P. Biochem. Pharmacol. (1996) [Pubmed]
  4. Comparison of the in vitro toxicity of 2',3'-dideoxynucleosides to murine hematopoietic progenitor cells. Du, D.L., Volpe, D.A., Grieshaber, C.K., Murphy, M.J. Int. J. Cell Cloning (1992) [Pubmed]
WikiGenes - Universities