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Chemical Compound Review

D-FddC     4-amino-5-fluoro-1-[(2R,5S)- 5...

Synonyms: beta-D-FddC, CHEMBL89498, SureCN396634, AG-D-21882, beta-D-5-F-ddC, ...
 
 
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Disease relevance of D-FddC

  • While neither compounds is a potent as ddC or 5-F-ddC (2b), 10b gives complete protection against the cytopathic effects of HIV in both host cell lines [1].
  • The rank-order of this ratio was ddC > 5-F-ddC >> ddA > ddI > ddG > beta-F-ddC > beta-F-ddA > beta-F-ddG with the highest ratios indicating the greatest potential for delayed toxicity [2].
 

High impact information on D-FddC

References

  1. Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines. Siddiqui, M.A., Driscoll, J.S., Marquez, V.E., Roth, J.S., Shirasaka, T., Mitsuya, H., Barchi, J.J., Kelley, J.A. J. Med. Chem. (1992) [Pubmed]
  2. Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production. Tsai, C.H., Doong, S.L., Johns, D.G., Driscoll, J.S., Cheng, Y.C. Biochem. Pharmacol. (1994) [Pubmed]
  3. Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity. Cui, L., Schinazi, R.F., Gosselin, G., Imbach, J.L., Chu, C.K., Rando, R.F., Revankar, G.R., Sommadossi, J.P. Biochem. Pharmacol. (1996) [Pubmed]
  4. Comparison of the in vitro toxicity of 2',3'-dideoxynucleosides to murine hematopoietic progenitor cells. Du, D.L., Volpe, D.A., Grieshaber, C.K., Murphy, M.J. Int. J. Cell Cloning (1992) [Pubmed]
 
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