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Chemical Compound Review

ddA (Antiviral)     [(2S,5R)-5-(6-aminopurin-9- yl)oxolan-2...

Synonyms: ddAdo, SureCN3541, CCRIS 428, CHEMBL23094, AC-332, ...
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Disease relevance of dideoxyadenosine


High impact information on dideoxyadenosine


Chemical compound and disease context of dideoxyadenosine


Biological context of dideoxyadenosine


Anatomical context of dideoxyadenosine


Associations of dideoxyadenosine with other chemical compounds


Gene context of dideoxyadenosine

  • Dideoxyadenosine (DDA) inhibited the GRP-induced growth effect in DU-145 and PC-346C, whereas oxadiazoloquinoxaline-1-one (ODQ) had no effect on (3)H-thymidine incorporation [30].
  • 2',3'-Dideoxyadenosine, which inhibits adenyl cyclase activity, reduced IL-1, IL-6, and IL-10 levels by 29, 15, and 28% respectively [31].
  • Furthermore, C-ANP(4-23)-induced increase in IP(3) formation was significantly potentiated by DDA and inhibited by FSK and db cAMP, whereas ET-1-induced increase in IP(3) production was not affected by FSK [32].
  • Following pretreatment with H-89 or dideoxyadenosine, the TSH-mediated PLD response was also significantly reduced [33].
  • Identification of Escherichia coli dnaE (polC) mutants with altered sensitivity to 2',3'-dideoxyadenosine [34].

Analytical, diagnostic and therapeutic context of dideoxyadenosine


  1. Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. Richman, D.D., Kornbluth, R.S., Carson, D.A. J. Exp. Med. (1987) [Pubmed]
  2. Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro. Mitsuya, H., Jarrett, R.F., Matsukura, M., Di Marzo Veronese, F., DeVico, A.L., Sarngadharan, M.G., Johns, D.G., Reitz, M.S., Broder, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  3. Dopamine D2L receptors stimulate Na+/K(+)-ATPase activity in murine LTK- cells. Yamaguchi, I., Walk, S.F., Jose, P.A., Felder, R.A. Mol. Pharmacol. (1996) [Pubmed]
  4. Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations. Smith, A.J., Meyer, P.R., Asthana, D., Ashman, M.R., Scott, W.A. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus. Lee, B., Luo, W.X., Suzuki, S., Robins, M.J., Tyrrell, D.L. Antimicrob. Agents Chemother. (1989) [Pubmed]
  6. Identification and role of adenylyl cyclase in auxin signalling in higher plants. Ichikawa, T., Suzuki, Y., Czaja, I., Schommer, C., Lessnick, A., Schell, J., Walden, R. Nature (1997) [Pubmed]
  7. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides. Perno, C.F., Yarchoan, R., Cooney, D.A., Hartman, N.R., Gartner, S., Popovic, M., Hao, Z., Gerrard, T.L., Wilson, Y.A., Johns, D.G. J. Exp. Med. (1988) [Pubmed]
  8. Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Gu, Z., Arts, E.J., Parniak, M.A., Wainberg, M.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. Balzarini, J., Hao, Z., Herdewijn, P., Johns, D.G., De Clercq, E. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. 2',3'-Dideoxyadenosine is selectively toxic for TdT-positive cells. Spigelman, Z., Duff, R., Beardsley, G.P., Broder, S., Cooney, D., Landau, N.R., Mitsuya, H., Ullman, B., McCaffrey, R. Blood (1988) [Pubmed]
  11. Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection. Hartman, N.R., Yarchoan, R., Pluda, J.M., Thomas, R.V., Marczyk, K.S., Broder, S., Johns, D.G. Clin. Pharmacol. Ther. (1990) [Pubmed]
  12. Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium. Urbach, V., Harvey, B.J. J. Physiol. (Lond.) (2001) [Pubmed]
  13. Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations. Thomas, J.M., Hoffman, B.B. Cell. Signal. (1992) [Pubmed]
  14. Production of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine from 2',3'-dideoxyuridine and the corresponding purine bases by resting cells of Escherichia coli AJ 2595. Shirae, H., Kobayashi, K., Shiragami, H., Irie, Y., Yasuda, N., Yokozeki, K. Appl. Environ. Microbiol. (1989) [Pubmed]
  15. Inhibition of reverse transcriptase from feline immunodeficiency virus by analogs of 2'-deoxyadenosine-5'-triphosphate. Cronn, R.C., Remington, K.M., Preston, B.D., North, T.W. Biochem. Pharmacol. (1992) [Pubmed]
  16. Nucleobase transporter-mediated permeation of 2',3'-dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRF-CEM cells. Gati, W.P., Paterson, A.R., Tyrrell, D.L., Cass, C.E., Moravek, J., Robins, M.J. J. Biol. Chem. (1992) [Pubmed]
  17. Ethanol induces apoptotic death of developing beta-endorphin neurons via suppression of cyclic adenosine monophosphate production and activation of transforming growth factor-beta1-linked apoptotic signaling. Chen, C.P., Kuhn, P., Chaturvedi, K., Boyadjieva, N., Sarkar, D.K. Mol. Pharmacol. (2006) [Pubmed]
  18. Tumor necrosis factor production in the perfused mouse liver and its pharmacological modulation by methylxanthines. Leist, M., Auer-Barth, S., Wendel, A. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  19. Biochemical genetic analysis of 2',3'-dideoxyadenosine metabolism in human T lymphocytes. Carson, D.A., Haertle, T., Wasson, D.B., Richman, D.D. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  20. Permeation and salvage of dideoxyadenosine in mammalian cells. Plagemann, P.G., Woffendin, C. Mol. Pharmacol. (1989) [Pubmed]
  21. Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine. Griffith, T.M., Chaytor, A.T., Edwards, D.H., Daverio, F., McGuigan, C. Br. J. Pharmacol. (2004) [Pubmed]
  22. Design of some nucleic acid antimetabolites: expectations and reality. Horwitz, J.P. Investigational new drugs. (1989) [Pubmed]
  23. The B lymphocyte is the immune cell target for 2',3'-dideoxyadenosine. Cao, W., Sikorski, E.E., Fuchs, B.A., Stern, M.L., Luster, M.I., Munson, A.E. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  24. Antiviral effects of 3'-azido-3'-deoxythymidine, 2',3'-dideoxycytidine, and 2',3'-dideoxyadenosine against simian acquired immunodeficiency syndrome-associated type D retrovirus in vitro. Tsai, C.C., Follis, K.E., Benveniste, R.E. AIDS Res. Hum. Retroviruses (1988) [Pubmed]
  25. Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine. Ahluwalia, G.S., Cooney, D.A., Shirasaka, T., Mitsuya, H., Driscoll, J.S., Johns, D.G. Mol. Pharmacol. (1994) [Pubmed]
  26. Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus. Burns, C.L., St Clair, M.H., Frick, L.W., Spector, T., Averett, D.R., English, M.L., Holmes, T.J., Krenitsky, T.A., Koszalka, G.W. J. Med. Chem. (1993) [Pubmed]
  27. The peptide TRH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex. Browning, K.N., Travagli, R.A. J. Physiol. (Lond.) (2001) [Pubmed]
  28. Comparative pharmacokinetics of new anti-HIV agents: 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine. Russell, J.W., Klunk, L.J. Biochem. Pharmacol. (1989) [Pubmed]
  29. Intracellular signaling of tumor necrosis factor-alpha in brain microvascular endothelial cells is mediated by a protein tyrosine kinase and protein kinase C-dependent pathway. Hudson, S.J., Cai, J.P., Thomas, V., Chin, Y.H. J. Neuroimmunol. (1996) [Pubmed]
  30. Androgen-independent growth is induced by neuropeptides in human prostate cancer cell lines. Jongsma, J., Oomen, M.H., Noordzij, M.A., Romijn, J.C., van Der Kwast, T.H., Schröder, F.H., van Steenbrugge, G.J. Prostate (2000) [Pubmed]
  31. Evidence for protein kinase C pathway in the response of human peripheral blood mononuclear cells to cholera toxin. Krakauer, T. Cell. Immunol. (1996) [Pubmed]
  32. Atrial natriuretic peptide-C receptor-induced attenuation of adenylyl cyclase signaling activates phosphatidylinositol turnover in A10 vascular smooth muscle cells. Mouawad, R., Li, Y., Anand-Srivastava, M.B. Mol. Pharmacol. (2004) [Pubmed]
  33. Activation of phospholipase D in FRTL-5 thyroid cells by forskolin and dibutyryl-cyclic adenosine monophosphate. Ginsberg, J., Gupta, S., Matowe, W.C., Kline, L., Brindley, D.N. Endocrinology (1997) [Pubmed]
  34. Identification of Escherichia coli dnaE (polC) mutants with altered sensitivity to 2',3'-dideoxyadenosine. Hiratsuka, K., Reha-Krantz, L.J. J. Bacteriol. (2000) [Pubmed]
  35. Pharmacokinetics of 2',3'-dideoxyadenosine in dogs. Wientjes, M.G., Placke, M.E., Chang, M.J., Page, J.G., Kluwe, W.M., Tomaszewski, J.E. Investigational new drugs. (1991) [Pubmed]
  36. Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Pauwels, R., Baba, M., Balzarini, J., Herdewijn, P., Desmyter, J., Robins, M.J., Zou, R.M., Madej, D., De Clercq, E. Biochem. Pharmacol. (1988) [Pubmed]
  37. Application of high-performance liquid chromatography and thermospray high-performance liquid chromatography-mass spectrometry to the analysis and identification of 2',3'-dideoxyadenosine and its metabolite in biological media. Blau, P.A., Hines, J.W., Voyksner, R.D. J. Chromatogr. (1987) [Pubmed]
  38. The cAMP-mediated protein kinase signal transduction pathway is involved in the pyrogenic effect of CRH in rats. Wang, H., Wang, Y., Qu, Y., Qi, R., Lu, D., Li, C., Yan, L. Chin. Med. J. (2001) [Pubmed]
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