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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AC1L9UER     2-[[3-[(2-amino-5-methanoyl- 4-oxo-1,6,7,8...

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Disease relevance of leucovorin

  • METHODS: Seventy chemotherapy naive patients with colorectal cancer were randomly assigned to oral glutamine (18 g/day) or placebo before the first cycle of FU (450 mg/m(2)) and FA (100 mg/m(2)) administered intravenously for five days [1].
 

High impact information on leucovorin

  • The maximum-tolerated dose (MTD) of UFT with this schedule, when administered concomitantly with oral LV 150 mg daily, is 300 mg/m2 daily [2].
  • AIM: To determine if oral glutamine prevents changes in intestinal absorption (IA) and permeability (IP) induced by FU/FA [1].
  • Synergism occurred in HCT116, demonstrating previously RNA-mediated FUra/LV cytotoxicity that could not be potentiated by IFN-gamma [3].
  • Because of their modest therapeutic index, currently employed regimens of 5-FU +/- LV plus IFN-alpha cannot be recommended for routine use at the present time [4].
 

Anatomical context of leucovorin

  • Data demonstrate that IFN-gamma combined with ZD9331 is synergistic in additional cell lines that demonstrate RNA-mediated FUra/LV cytotoxicity, and that a major target of interaction is at the level of caspases, downstream of Fas, and independent of involvement of either the mitochondria or survivin [3].

References

  1. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Daniele, B., Perrone, F., Gallo, C., Pignata, S., De Martino, S., De Vivo, R., Barletta, E., Tambaro, R., Abbiati, R., D'Agostino, L. Gut (2001) [Pubmed]
  2. Uracil-ftorafur: an oral fluoropyrimidine active in colorectal cancer. Sulkes, A., Benner, S.E., Canetta, R.M. J. Clin. Oncol. (1998) [Pubmed]
  3. Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin. Geller, J., Petak, I., Szucs, K.S., Nagy, K., Tillman, D.M., Houghton, J.A. Clin. Cancer Res. (2003) [Pubmed]
  4. Treatment of advanced colorectal cancer with 5-fluorouracil and interferon-alpha: an overview of clinical trials. Raderer, M., Scheithauer, W. Eur. J. Cancer (1995) [Pubmed]
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