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Chemical Compound Review

AC1LAHXQ     6-(tetradecylamino)-3-[3,4,5- trihydroxy-6...

Synonyms: AG-K-42477, CTK6E0212, N-tetradecylamino-1-deoxylactitol
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Disease relevance of AIDS-058808

  • Thus, the data suggest that SPC3 affects HIV-1 infection by two distinct mechanisms: (i) prevention of GalCer-mediated HIV-1 attachment to the surface of CD4-/GalCer+ cells and (ii) post-binding inhibition of HIV-1 entry into CD4+ lymphocytes [1].

High impact information on AIDS-058808

  • Accordingly, SPC3 was found to inhibit the binding of gp120 to the GalCer receptor [1].
  • Rat ama4 bound to an affinity matrix on mannose-sepharose but lost all of the SP-A functions except carbohydrate binding and Ca2+-independent GalCer binding [2].
  • SP-A binds to dipalmitoyl phosphatidylcholine (DPPC) and galactosylceramide (GalCer) and MBP-A binds to phosphatidylinositol (PI) [2].
  • Through development the hydroxy-species contributed 56-60% to GalCer and 28-41% to SGalCer in spinal cord, whereas in cerebrum of 24-week-old rats 73% of GalCer and 48% of SGalCer was alpha-hydroxylated in the ceramide moiety [3].

Gene context of AIDS-058808

  • All of the chimeras bound DPPC and GalCer with activity comparable to recombinant SP-A [4].


  1. SPC3, a synthetic peptide derived from the V3 domain of human immunodeficiency virus type 1 (HIV-1) gp120, inhibits HIV-1 entry into CD4+ and CD4- cells by two distinct mechanisms. Yahi, N., Fantini, J., Baghdiguian, S., Mabrouk, K., Tamalet, C., Rochat, H., Van Rietschoten, J., Sabatier, J.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Introduction of mannose binding protein-type phosphatidylinositol recognition into pulmonary surfactant protein A. Chiba, H., Sano, H., Saitoh, M., Sohma, H., Voelker, D.R., Akino, T., Kuroki, Y. Biochemistry (1999) [Pubmed]
  3. Hydroxy- and non-hydroxy-galactolipids in developing rat CNS. De Haas, C.G., Lopes-Cardozo, M. Int. J. Dev. Neurosci. (1995) [Pubmed]
  4. The mannose-binding protein A region of glutamic acid185-alanine221 can functionally replace the surfactant protein A region of glutamic acid195-phenylalanine228 without loss of interaction with lipids and alveolar type II cells. Honma, T., Kuroki, Y., Tsunezawa, W., Ogasawara, Y., Sohma, H., Voelker, D.R., Akino, T. Biochemistry (1997) [Pubmed]
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