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Chemical Compound Review:

AC1LAIIQ 9-[(2R,4S,5R)-4-hydroxy-5...

Synonyms: AG-J-29115, CTK7J7655

Awaya, A. et al., Sienaert, R. et al., Sienaert, R. et al., Balzarini, J. et al., Seto, S. et al., et al.

Seto, Tanioka, Ikeda, Izawa, Balzarini, McGuigan, Balzarini, McGuigan,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIDS-059323

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase [1].
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase [2].
A series of novel bicyclic pyrimidine derivatives was prepared as part of a search for NK1 antagonist aimed at the treatment of urinary incontinence [3].
From the study using cultured human and mouse neuroblastoma cells, we found that a new type of synthetic bicyclic pyrimidine compounds possessing piperazine moiety strongly promoted neurite outgrowth in neuroblastoma cell lines human GOTO and mouse neuro 2a [4].

Analytical, diagnostic and therapeutic context of AIDS-059323

Bicyclic pyrimidine nucleoside analogues (BCNAs) represent highly potent and selective inhibitors of varicella-zoster virus (VZV) replication in cell culture [5].
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides [6].

References

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Sienaert, R., Naesens, L., Brancale, A., De Clercq, E., McGuigan, C., Balzarini, J. Mol. Pharmacol. (2002) [Pubmed]
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. Sienaert, R., Andrei, G., Snoeck, R., De Clercq, E., McGuigan, C., Balzarini, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Design, synthesis, and evaluation of novel 2-substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-ones as NK1 antagonists. Seto, S., Tanioka, A., Ikeda, M., Izawa, S. Bioorg. Med. Chem. (2005) [Pubmed]
Neurotropic pyrimidine heterocyclic compounds. I. The newly synthesized pyrimidine compounds promote neurite outgrowth of GOTO and neuro 2a neuroblastoma cell lines, and potentiate nerve growth factor (NGF)-induced neurite sprouting of PC 12 cells. Awaya, A., Kobayashi, H., Horikomi, K., Tanaka, S., Kabir, A.M., Yokoyama, K., Ohno, H., Kato, K., Kitahara, T., Tomino, I. Biol. Pharm. Bull. (1993) [Pubmed]
Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. Balzarini, J., McGuigan, C. J. Antimicrob. Chemother. (2002) [Pubmed]
Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides. Balzarini, J., McGuigan, C. Biochim. Biophys. Acta (2002) [Pubmed]

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