Disease relevance of Phenacerum

• Phenacemide therapy was well tolerated with a minimum of untoward side effects and no evidence of irreversible drug toxicity [1].
• OBJECTIVE: To report two cases of increased true serum creatinine (Scr) without renal failure caused by an anticonvulsant drug, phenacemide, and to discuss the possible mechanisms [2].
• Three adolescent patients with severe seizure disorders were treated with phenacemide [3].

High impact information on Phenacerum

• The three-dimensional molecular structures of the potent anticonvulsant agents phenacemide and ethylphenacemide have been determined by single-crystal x-ray diffraction [4].
• Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations [1].
• Structure-activity relationships in the effects of phenacemide analogs on serum creatinine and anticonvulsant activity [5].

Analytical, diagnostic and therapeutic context of Phenacerum

• We developed a rapid and sensitive assay for the determination of plasma phenacemide concentrations by high performance liquid chromatography to monitor drug levels during therapy [1].
• We used monotherapy with phenacemide to treat complex partial seizures in 13 children who were refractory to conventional antiepileptic drug therapy [1].

References