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Chemical Compound Review:

Pindobind 2-bromo-N-[4-[2-[[2-hydroxy- 3-(1H-indol-4...

Synonyms: CHEMBL156628, CHEBI:360847, AR-1D9692, PDSP1_001698, PDSP2_001681, ...

Frank, M.G. et al., Abdul, M. et al., Oleskevich, S. et al., Bell, R. et al., Cao, B.J. et al., et al.

Frank, Johnson, Hendricks, Frank,

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High impact information on Pindobind

The 5-HT1A receptor antagonist, pindobind 5-HT1A (5 microM), had no effect on the depolarizing response to 5-HT [1].
Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. I. Pindolol enantiomers and pindobind 5-HT1A [2].
Of these, the 5-HT1A antagonist pindobind had the most marked antiproliferative effect in vitro [3].
Pindobind also had marked growth-inhibitory effects on the aggressive PC-3 cell line in vivo, in athymic nude mice [3].
Catalase inhibited pindobind-induced suppression of NKCA [4].

Anatomical context of Pindobind

Pindobind-treated monocytes suppressed NKCA, whereas pindobind treatment of PBL did not affect NKCA [4].
NK cell activity (NKCA) was measured after exposure of mononuclear cells to the 5-HT1A receptor antagonist pindobind and the 5-HT(1C/2) receptor antagonist ketanserin [4].
Elutriated monocytes were exposed to pindobind, incubated with peripheral blood lymphocytes (PBL) in the presence or absence of an H2O2 scavenger catalase, and NKCA measured [4].

Gene context of Pindobind

The sEPSP was studied in isolation with the use of a selective 5-HT1A receptor antagonist, pindobind 5HT1A, which eliminated the inhibitory postsynaptic potential (IPSP) that preceded the sEPSP [5].
Effects of pindobind 5-hydroxytryptamine1A (5-HT1A), a novel and potent 5-HT1A antagonist, on social and agonistic behaviour in male albino mice [6].

References

The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro. Albert, A.P., Spyer, K.M., Brooks, P.A. Br. J. Pharmacol. (1996) [Pubmed]
Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. I. Pindolol enantiomers and pindobind 5-HT1A. Cao, B.J., Rodgers, R.J. Pharmacol. Biochem. Behav. (1997) [Pubmed]
Growth inhibition of human prostatic carcinoma cell lines by serotonin antagonists. Abdul, M., Anezinis, P.E., Logothetis, C.J., Hoosein, N.M. Anticancer Res. (1994) [Pubmed]
Monocyte 5-HT1A receptors mediate pindobind suppression of natural killer cell activity: modulation by catalase. Frank, M.G., Johnson, D.R., Hendricks, S.E., Frank, J.L. Int. Immunopharmacol. (2001) [Pubmed]
Cocaine prolongs norepinephrine synaptic potentials in rat dorsal raphe. Oleskevich, S., Williams, J.T. J. Neurophysiol. (1995) [Pubmed]
Effects of pindobind 5-hydroxytryptamine1A (5-HT1A), a novel and potent 5-HT1A antagonist, on social and agonistic behaviour in male albino mice. Bell, R., Hobson, H. Pharmacol. Biochem. Behav. (1993) [Pubmed]

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