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Chemical Compound Review

Butiphos     1-bis(butylsulfanyl) phosphorylsulfanylbutane

Synonyms: Fossfall, Tribufos, Butifos, Tribuphos, TBTP, ...
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Disease relevance of Ortho phosphate defoliant

  • The toxicity of i.p.-administered PAF (LD50 ca. 0.5 mg/kg) was increased less than 2-fold by pretreatment with tribufos or the C(13)n-alkyl methylphosphonofluoridate [1].

High impact information on Ortho phosphate defoliant

  • Several key OP pesticides and their oxon metabolites were very poor inhibitors of mouse brain and human plasma PAF-AH in vitro but moderately active for mouse brain and blood PAF-AH in vivo (e.g., tribufos defoliant and profenofos insecticide, presumably following oxidative bioactivation) [1].
  • The plant defoliant tribufos inhibits CB1 in vivo, without cholinergic poisoning signs, by 50% at 50 mg/kg intraperitoneally with a recovery half-time of 3-4 days, indicating covalent derivatization [2].
  • The analytical findings for paraquat are compared with those for S,S,S-tributylphosphorotrithioate (DEF), a component of the harvest aid mixture employed, and discussed in terms of occupational exposure, potential hazard, and recommended occupational practices [3].
  • The esterase inhibitor S,S,S-tributyl-phosphorotrithioate (DEF) was able strongly to synergise bifenthrin toxicity in the resistant strain [4].
  • Including the synergists piperonyl butoxide, a cytochrome P-450 monooxygenase inhibitor, or S,S,S-tributylphosphorotrithioate, an esterase inhibitor, in the methiocarb bioassays partially suppressed resistance in the most resistant populations [5].

Chemical compound and disease context of Ortho phosphate defoliant


Associations of Ortho phosphate defoliant with other chemical compounds


Gene context of Ortho phosphate defoliant


  1. Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates. Quistad, G.B., Fisher, K.J., Owen, S.C., Klintenberg, R., Casida, J.E. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  2. Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides. Quistad, G.B., Nomura, D.K., Sparks, S.E., Segall, Y., Casida, J.E. Toxicol. Lett. (2002) [Pubmed]
  3. Sampling and analysis of airborne residues of paraquat in treated cotton field environments. Seiber, J.N., Woodrow, J.E. Arch. Environ. Contam. Toxicol. (1981) [Pubmed]
  4. Esterase-mediated bifenthrin resistance in a multiresistant strain of the two-spotted spider mite, Tetranychus urticae. Van Leeuwen, T., Tirry, L. Pest Manag. Sci. (2007) [Pubmed]
  5. Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). Jensen, S.E. J. Econ. Entomol. (2000) [Pubmed]
  6. Monitoring and characterization of diamondback moth (Lepidoptera: Plutellidae) resistance to spinosad. Zhao, J.Z., Li, Y.X., Collins, H.L., Gusukuma-Minuto, L., Mau, R.F., Thompson, G.D., Shelto, A.M. J. Econ. Entomol. (2002) [Pubmed]
  7. Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. Johnson, R.M., Wen, Z., Schuler, M.A., Berenbaum, M.R. J. Econ. Entomol. (2006) [Pubmed]
  8. Effects of three synergists on pyrethroid resistance in the German cockroach (Dictyoptera: Blattellidae). Cochran, D.G. J. Econ. Entomol. (1994) [Pubmed]
  9. Inheritance and synergism of resistance to imidacloprid in the Colorado potato beetle (Coleoptera: Chrysomelidae). Zhao, J.Z., Bishop, B.A., Grafius, E.J. J. Econ. Entomol. (2000) [Pubmed]
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