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Chemical Compound Review

METHIOCARB     (3,5-dimethyl-4- methylsulfanyl-phenyl) N...

Synonyms: Grandslam, Lizetan, Mesurol, Certan, Draza, ...
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Disease relevance of METHIOCARB


High impact information on METHIOCARB


Biological context of METHIOCARB

  • Crystal and molecular structure of carbamate insecticides. 1. Mesurol [7].
  • Methiocarb appeared to be noncumulative when measured by an index of chronicity: birds consumed several LD50 doses during a day's feeding, and when deaths occurred, they appeared to be due to acute intoxication [8].

Associations of METHIOCARB with other chemical compounds


Gene context of METHIOCARB


Analytical, diagnostic and therapeutic context of METHIOCARB

  • Determination of carbaryl, carbofuran and methiocarb in cucumbers and strawberries by monoclonal enzyme immunoassays and high-performance liquid chromatography with fluorescence detection. An analytical comparison [9].
  • These studies reveal that cells obtained from certan patients are particularly sensitive to the cytoxic effects of interferon, and it may be useful to monitor the erythropoietic state of the patient during interferon chemotherapy [17].
  • Methiocarb was extracted from surface water samples collected at experimental rice field sites in Louisiana and Texas. The sampling system consisted of a single-stage 90-mm Empore extraction disk unit equipped with a battery-powered vacuum pump [18].


  1. Survival tests with Chironomus riparius exposed to spiked sediments can profit from DEBtox model. Péry, A.R., Ducrot, V., Mons, R., Miège, C., Gahou, J., Gorini, D., Garric, J. Water Res. (2003) [Pubmed]
  2. Allergic contact dermatitis due to methiocarb (Mesurol). Willems, P.W., Geursen-Reitsma, A.M., van Joost, T. Contact Derm. (1997) [Pubmed]
  3. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Kojima, H., Katsura, E., Takeuchi, S., Niiyama, K., Kobayashi, K. Environ. Health Perspect. (2004) [Pubmed]
  4. Extrahepatic metabolism of carbamate and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. Furnes, B., Schlenk, D. Drug Metab. Dispos. (2005) [Pubmed]
  5. In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily. Usmani, K.A., Karoly, E.D., Hodgson, E., Rose, R.L. Drug Metab. Dispos. (2004) [Pubmed]
  6. Stability studies of carbamate pesticides and analysis by gas chromatography with flame ionization and nitrogen-phosphorus detection. Santos Delgado, M.J., Rubio Barroso, S., Fernández-Tostado, G.T., Polo-Díez, L.M. Journal of chromatography. A. (2001) [Pubmed]
  7. Crystal and molecular structure of carbamate insecticides. 1. Mesurol. Takusagawa, F., Jacobson, R.A. J. Agric. Food Chem. (1977) [Pubmed]
  8. The chronic toxicity of methiocarb to grackles, doves, and quail and reproductive effect in quail. Schafer, E.W., Brunton, R.B., Lockyer, N.F., Cunningham, D.J. Bulletin of environmental contamination and toxicology. (1975) [Pubmed]
  9. Determination of carbaryl, carbofuran and methiocarb in cucumbers and strawberries by monoclonal enzyme immunoassays and high-performance liquid chromatography with fluorescence detection. An analytical comparison. Abad, A., Moreno, M.J., Pelegrí, R., Martínez, M.I., Sáez, A., Gamón, M., Montoya, A. Journal of chromatography. A. (1999) [Pubmed]
  10. Hydroperoxide-dependent sulfoxidation catalyzed by soybean microsomes. Blee, E., Durst, F. Arch. Biochem. Biophys. (1987) [Pubmed]
  11. Factors influencing discrimination between insecticide-treated and untreated foods by northern bobwhite. Bennett, R.S. Arch. Environ. Contam. Toxicol. (1989) [Pubmed]
  12. Dermal in vitro penetration of methiocarb, paclobutrazol, and pirimicarb. Nielsen, J.B., Nielsen, F. Occupational and environmental medicine. (2000) [Pubmed]
  13. The excretion in urine of four insecticidal carbamates and their phenolic metabolites after oral administration to rats. van Hoof, F., Heyndrickx, A. Arch. Toxicol. (1975) [Pubmed]
  14. Effects of the pesticides prochloraz and methiocarb on human estrogen receptor alpha and beta mRNA levels analyzed by on-line RT-PCR. Hofmeister, M.V., Bonefeld-Jørgensen, E.C. Toxicology in vitro : an international journal published in association with BIBRA. (2004) [Pubmed]
  15. A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes. Grothusen, A., Hardt, J., Bräutigam, L., Lang, D., Böcker, R. Arch. Toxicol. (1996) [Pubmed]
  16. Stereoselective sulfoxidation of the pesticide methiocarb by flavin-containing monooxygenase and cytochrome P450-dependent monooxygenases of rat liver microsomes. Anticholinesterase activity of the two sulfoxide enantiomers. Buronfosse, T., Moroni, P., Benoît, E., Rivière, J.L. J. Biochem. Toxicol. (1995) [Pubmed]
  17. Suppressive effect of human interferons on erythroid colony growth in disorders of erythropoiesis. Lutton, J.D., Levere, R.D. J. Lab. Clin. Med. (1980) [Pubmed]
  18. Novel field sampling procedure for the determination of methiocarb residues in surface waters from rice fields. Primus, T.M., Kohler, D.J., Avery, M., Bolich, P., Way, M.O., Johnston, J.J. J. Agric. Food Chem. (2001) [Pubmed]
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