Disease relevance of C10980

• The pyrethroid bifenthrin, due to its high concentrations and relative toxicity as compared to other pyrethroids, was likely responsible for the majority of the toxicity at most sites [1].
• When compared with controls dosed only with DNB, Bifenthrin tremor made both the ataxia and other functional effects caused by DNB more pronounced [2].
• In the aqueous phase, bifenthrin was rapidly degraded by strains of Stenotrophomonas acidaminiphila, and the half-life (t1/2) was reduced from >700 h to 30 to 131 h [3].
• The combined mosquitocidal activities of bifenthrin is considered more effective especially in the control of dengue vectors [4].
• Bacillus thuringiensis Berliner var kurstaki controlled neonates within 3 days but was less active against late instars, with shorter residual action than bifenthrin or spinosad [5].

High impact information on C10980

• Very low toxicity was observed with bifenthrin (LD50 = 5157.8 mg/m2) [6].
• A. lacunatus showed higher parasitism rate with bifenthrin than with deltamethrin indicating a higher selectivity of the first compound to the biocontrol agent [7].
• The combination of bifenthrin or dimethoate with a synergist indicated changes in the ability of the more resistant 1995 mites to detoxify insecticides [8].
• The synergist diethyl maleate (DEM) enhanced the toxicities of bifenthrin and lambda-cyhalothrin against BGM by 2.2- and 2.9- fold, respectively, and enhanced the toxicity of bifenthrin against TSM by 4.1-fold [9].
• The esterase inhibitor S,S,S-tributyl-phosphorotrithioate (DEF) was able strongly to synergise bifenthrin toxicity in the resistant strain [10].

Chemical compound and disease context of C10980

• The present study has extended this earlier work and examined the ability of carboxylesterase activity to remove permethrin- and bifenthrin-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in a variety of matrices, including laboratory water, Sacramento River (CA, USA) water, and Salinas River (CA, USA) interstitial water [11].
• For bifenthrin, cyfluthrin, lambda-cyhalothrin, and deltamethrin, the 10th centile values for all organisms were 15, 12, 10, and 9 ng/L, respectively, indicating similar or somewhat lower toxicity than cypermethrin [12].
• Bifenthrin toxicity was determined using trypan blue exclusion [13].
• The influence of post-treatment temperature on the toxicities of two pyrethroids (lambda-cyhalothrin and bifenthrin), a carbamate (methomyl) and a spinosyn (spinosad) to Ostrinia nubilalis (Hubner) larvae was evaluated in laboratory assays [14].

Biological context of C10980

• Bifenthrin causes neurite retraction in the absence of cell death: a model for pesticide associated neurodegeneration [13].
• MATERIAL/METHODS: PC12 cells were exposed to varying concentrations of technical grade bifenthrin or Ortho Home Defense. Cell viability was determined using the AlmarBlue Toxicity Assay. Nontoxic concentrations of these chemicals were concomitantly with nerve growth factor and neurite outgrowth was assessed [15].
• The paper also describes the pilot application of this method to a study of South Australian pest control operators handling bifenthrin [16].
• Estimating occupational exposure to the pyrethroid termiticide bifenthrin by measuring metabolites in urine [16].
• Bifenthrin did not inhibit PHA induced cell aggregation in all cell lines tested [17].

Anatomical context of C10980

• PolicosanolPlus((R)) and Neuroprevintrade mark are nutraceutical supplements which ameliorate the effects of bifenthrin on neurite outgrowth and retraction [18].
• RESULTS: Bifenthrin was not toxic to PC12 cells at concentrations ranging from 1 x 10(-10) M to 1 x 10(-4) M [13].
• Bifenthrin activates homotypic aggregation in human T-cell lines [17].
• Here, we used the PC12 neuronal cell line to examine the effect of bifenthrin on the formation of neurites and the potential developmental neurotoxicity of this pesticide [15].
• BACKGROUND: Here, we addressed the concern that, despite the lack of overt toxicity, exposure to low levels of the common household pyrethroid pesticide, bifenthrin, could cause harm to the immune system [17].

Associations of C10980 with other chemical compounds

• Increased soil pH diminished residual activity of termiticide in the following order: imidacloprid > fipronil > chlorpyrifos = bifenthrin > permethrin > cypermethrin [19].
• Percentage of mortality in these bioassays was 15, 43, and 13 for bifenthrin, chlorpyrifos, and imidacloprid respectively [20].
• A single village control trial for Triatoma pallidipennis and T. barberi was conducted using three synthetic pyrethroids (bifenthrin, cyfluthrin, and deltamethrin), evaluated as residual treatments in separate sectors, with complete coverage indoors and in peridomiciliary areas [21].
• Termite mortalities in contact bioassays remained high for bifenthrin and chlorpyrifos throughout the 48-mo sampling period; however, mortality of termites exposed to imidacloprid-treated soil dropped after the initial sampling [20].
• In this study, we assess the efficacy of bifenthrin (Onyx) and carbaryl (Sevin SL) for protecting: ponderosa pine, Pinus ponderosa Dougl. ex [22].

Gene context of C10980

• Expression of GRP94 was found to be increased and HSP27 lowered by the highest concentrations of bifenthrin commercial formulations [23].
• CONCLUSIONS: The results here show that bifenthrin activates T-cell function by stimulating ICAM/LFA-1 mediated homotypic aggregation [17].
• Bifenthrin with irrigation at 1 h after insecticide treatment provided better mole cricket control than that of irrigation at 5 min after treatment at 30 DAT only in the 1998 test [24].
• Method development, validation, and analysis of bifenthrin residues in fresh and dry cilantro foliages and cilantro seeds using GC-ECD [25].

Analytical, diagnostic and therapeutic context of C10980

• Laboratory bioassays showed the field mites to be 3- to 23-fold more tolerant to bifenthrin than the susceptible laboratory culture [8].
• Effects of bifenthrin on Daphnia magna during chronic toxicity test and the recovery test [26].
• Bifenthrin-hydrolysing activity in the resistant and susceptible strains was examined in vitro and quantified with gas chromatography [10].

References