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Chemical Compound Review

PIPERONYL BUTOXIDE     5-[2-(2- butoxyethoxy)ethoxymethyl]- 6...

Synonyms: Butacide, Butocide, Butoxide, Obilique, Alleviate, ...
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Disease relevance of PIPERONYL BUTOXIDE


Psychiatry related information on PIPERONYL BUTOXIDE

  • Piperonyl butoxide, a microsomal monooxygenase inhibitor, administered intraperitoneally to mice exerts peak anti-maximal electroshock activity and peak neurotoxicity at 5 and 7h, respectively [6].
  • The animals performed three trials in multiple water T-maze at 10 weeks of age, and the number of errors was significantly decreased in treatment groups on the 3rd trial, while there was no biologically significant effect of piperonyl butoxide on maze learning [7].
  • From these results, piperonyl butoxide showed adverse effects on the motor activity of the exploratory behaviour in male mice [7].
  • The effects of these compounds on the feeding behavior and performance (with and without piperonyl butoxide pretreatment) of Spodoptera littoralis larvae and Leptinotarsa decemlineata adults indicate that some strongly deterred these insects, L. decemlineata being less sensitive than S. littoralis [8].

High impact information on PIPERONYL BUTOXIDE

  • Prior treatment of the microsomes with piperonyl butoxide or another mixed-function oxidase inhibitor markedly decreases the activation [9].
  • Piperonyl butoxide also protects against brain acetylcholinesterase inhibition and cholinergic symptoms in chicks resulting from (-)-profenofos administration, thus establishing the importance of the oxidative bioactivation of S-alkyl phosphorothiolate pesticides in vivo [9].
  • (i) The effect of a specific P450 inhibitor, piperonyl butoxide, on larval survival through eclosion on each cactus substrate was investigated [10].
  • Blockers of the cytochrome P-450 epoxygenase, such as SKF 525A and piperonyl butoxide, compounds that have different molecular structures, also suppressed secretagogue-induced ACTH release [11].
  • At 60 min, the amount of isaxonine metabolite covalently bound per mg of protein was similar in plasma membranes (0.42 nmole protein-1) and in microsomes (0.38); both values were decreased by about 70% in rats pretreated with piperonyl butoxide, an inhibitor of cytochrome P-450 [12].

Chemical compound and disease context of PIPERONYL BUTOXIDE


Biological context of PIPERONYL BUTOXIDE


Anatomical context of PIPERONYL BUTOXIDE


Associations of PIPERONYL BUTOXIDE with other chemical compounds




Analytical, diagnostic and therapeutic context of PIPERONYL BUTOXIDE


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