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Chemical Compound Review

Curacron     4-bromo-2-chloro-1-(ethoxy- propylsulfanyl...

Synonyms: Ictacron, Polycron, Selecron, Calofos, Prowess, ...
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Disease relevance of Curacron


High impact information on Curacron


Biological context of Curacron

  • Mixtures of atropine with eserine, pyridinium oximes, or the bispyridinium compound SAD-128 increased the LD50 of coadministered profenofos by up to sevenfold in chicks and fourfold in mice [6].
  • The initial disappearance of profenofos appeared to follow first order kinetics with different rates of reaction of 0.38, 0.40 and 0.35 day(-1) for hot pepper, sweet pepper and eggplant, respectively [7].
  • Concentration of melon volatiles by steam distillation yielded a product identical to that obtained by hydrolysis of profenofos, identified as 4-bromo-2-chlorophenol [8].
  • Thrombin is the most sensitive blood-clotting factor with IC-50 values of 19 to 160 microM for tribufos, the cyclic phosphonate, isoflurophate, and profenofos; plasmin and kallikrein are less affected (IC-50 >100 microM) [9].
  • The two pest control agents, buprofezin and petroleum oil (Super Royal), were tested to evaluate their potential mutagenicity, in comparison with the organophosphorus insecticide profenofos [10].

Anatomical context of Curacron

  • The results indicated that the accumulation of profenofos was the highest in viscera followed by head and body, with depuration rates of 6.14, 0.16 and 0.12 micro g/h, respectively [11].
  • Cytotoxicity and genotoxicity induced by the pesticide profenofos on cultured human peripheral blood lymphocytes [12].

Associations of Curacron with other chemical compounds


Gene context of Curacron

  • Although profenofos was active against electric eel AChE, incubation of the OP with MCPBA did not enhance its anti-AChE properties toward the eel or insect AChEs [15].
  • Spring onionwere sampled at different time intervals and analyzed for profenofos residues using a GC equipped with NPD detector [16].

Analytical, diagnostic and therapeutic context of Curacron


  1. Chromosome aberrations in spermatogonia and sperm abnormalities in Curacron-treated mice. el Nahas, S.M., de Hondt, H.A., Abdou, H.E. Mutat. Res. (1989) [Pubmed]
  2. Insect detoxifying enzymes: their importance in pesticide synergism and resistance. Ishaaya, I. Arch. Insect Biochem. Physiol. (1993) [Pubmed]
  3. Effect of profenofos feeding on food consumption, body weight and tissue residues in chickens. Eglal, n.u.l.l., Salem, A.G., Abdel-Azize, T., Azza, n.u.l.l., Aboul el Wafa, M., Hesham, n.u.l.l., El-Derea, B. The Journal of the Egyptian Public Health Association (1994) [Pubmed]
  4. Oxidative bioactivation of S-alkyl phosphorothiolate pesticides: stereospecificity of profenofos insecticide activation. Wing, K.D., Glickman, A.H., Casida, J.E. Science (1983) [Pubmed]
  5. In vivo evaluation of the genotoxic potential of curacron in somatic cells of mice. el Nahas, S.M., de Hondt, H.A., Ramadan, A.I. Environ. Mol. Mutagen. (1988) [Pubmed]
  6. Profenofos insecticide bioactivation in relation to antidote action and the stereospecificity of acetylcholinesterase inhibition, reactivation, and aging. Glickman, A.H., Wing, K.D., Casida, J.E. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  7. Residual behaviour of profenofos on some field-grown vegetables and its removal using various washing solutions and household processing. Radwan, M.A., Abu-Elamayem, M.M., Shiboob, M.H., Abdel-Aal, A. Food Chem. Toxicol. (2005) [Pubmed]
  8. Identification of 4-bromo-2-chlorophenol as a contaminant responsible for organoleptic taint in melons. Sanchez Saez, J.J., Herce Garraleta, M.D., Calvo Anton, P., Folgueiras Alonso, M.L. Food additives and contaminants. (1991) [Pubmed]
  9. Sensitivity of blood-clotting factors and digestive enzymes to inhibition by organophosphorus pesticides. Quistad, G.B., Casida, J.E. J. Biochem. Mol. Toxicol. (2000) [Pubmed]
  10. Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice. Fahmy, M.A., Abdalla, E.F. Journal of applied toxicology : JAT. (1998) [Pubmed]
  11. Toxic effects of profenofos on tissue acetylcholinesterase and gill morphology in a euryhaline fish, Oreochromis mossambicus. Venkateswara Rao, J., Shilpanjali, D., Kavitha, P., Madhavendra, S.S. Arch. Toxicol. (2003) [Pubmed]
  12. Cytotoxicity and genotoxicity induced by the pesticide profenofos on cultured human peripheral blood lymphocytes. Prabhavathy Das, G., Pasha Shaik, A., Jamil, K. Drug and chemical toxicology. (2006) [Pubmed]
  13. Estimation of apoptosis and necrosis caused by pesticides in vitro on human lymphocytes using DNA diffusion assay. Das, G.P., Shaik, A.P., Jamil, K. Drug and chemical toxicology. (2006) [Pubmed]
  14. In vitro effect of profenofos, fenvalerate and dimilin on protein and RNA biosynthesis by rabbit liver and muscle tissues. el-Sebae, A.H., Salem, M.H., el-Assar, M.R., Enan, E.E. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1988) [Pubmed]
  15. Evaluation of peracid activated organophosphates in studies of insecticide resistance conferred by insensitive acetylcholinesterases. Byrne, F.J., Toscano, N.C. J. Econ. Entomol. (2002) [Pubmed]
  16. Residues of profenofos in spring onion. Talebi, K., Ghassami, M.R. Communications in agricultural and applied biological sciences. (2004) [Pubmed]
  17. Profenofos metabolites in human poisoning. Gotoh, M., Sakata, M., Endo, T., Hayashi, H., Seno, H., Suzuki, O. Forensic Sci. Int. (2001) [Pubmed]
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