Disease relevance of Curacron

• Curacron was found to produce a significant increase in structural chromosomal aberrations after acute and subacute treatments [1].
• Monocrotophos, profenofos, acephate, and methidathion inhibited pyrethroid esterase activity in B. tabaci and synergized considerably the toxicity of cypermethrin [2].
• Effect of profenofos feeding on food consumption, body weight and tissue residues in chickens [3].

High impact information on Curacron

• This activation is stereospecific for the chiral isomers of O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothiolate (profenofos insecticide); the more toxic (-) isomer becomes a 34-fold better inhibitor of acetylcholinesterase in vitro, whereas the less toxic (+) isomer is deactivated by a factor of 2 [4].
• In order to assay its mutagenic potential in mammalian germ cells chromosomal aberrations in spermatogonial cells and sperm abnormalities were examined in mice after Curacron treatment [1].
• Chromosome aberrations in spermatogonia and sperm abnormalities in Curacron-treated mice [1].
• An inhibition of 40.2% in sperm count and of 74.5% in sperm motility occurred after treatment with 60 mg/kg Curacron [1].
• Cytogenetic effects produced in somatic cells by Curacron, a phosphoric acid ester insecticide, were assessed in mice by three criteria: chromosome aberrations, sister chromatid exchange (SCE), and micronucleus induction [5].

Biological context of Curacron

• Mixtures of atropine with eserine, pyridinium oximes, or the bispyridinium compound SAD-128 increased the LD50 of coadministered profenofos by up to sevenfold in chicks and fourfold in mice [6].
• The initial disappearance of profenofos appeared to follow first order kinetics with different rates of reaction of 0.38, 0.40 and 0.35 day(-1) for hot pepper, sweet pepper and eggplant, respectively [7].
• Concentration of melon volatiles by steam distillation yielded a product identical to that obtained by hydrolysis of profenofos, identified as 4-bromo-2-chlorophenol [8].
• Thrombin is the most sensitive blood-clotting factor with IC-50 values of 19 to 160 microM for tribufos, the cyclic phosphonate, isoflurophate, and profenofos; plasmin and kallikrein are less affected (IC-50 >100 microM) [9].
• The two pest control agents, buprofezin and petroleum oil (Super Royal), were tested to evaluate their potential mutagenicity, in comparison with the organophosphorus insecticide profenofos [10].

Anatomical context of Curacron

• The results indicated that the accumulation of profenofos was the highest in viscera followed by head and body, with depuration rates of 6.14, 0.16 and 0.12 micro g/h, respectively [11].
• Cytotoxicity and genotoxicity induced by the pesticide profenofos on cultured human peripheral blood lymphocytes [12].

Associations of Curacron with other chemical compounds

• Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice [10].
• Organophosphorus pesticides like monocrotophos, profenofos, chlorpyrifos, and acephate are most commonly used in India for agriculture and public health programs [13].
• The present study was carried out to investigate the effect of Curacron (profenofos), Sumicidin (fenvalerate) and Dimilin (difluobenzuron) on the in vitro rate of protein and RNA synthesis by rabbit liver and muscle tissues [14].

Gene context of Curacron

• Although profenofos was active against electric eel AChE, incubation of the OP with MCPBA did not enhance its anti-AChE properties toward the eel or insect AChEs [15].
• Spring onionwere sampled at different time intervals and analyzed for profenofos residues using a GC equipped with NPD detector [16].

Analytical, diagnostic and therapeutic context of Curacron

• Morphological sperm abnormalities increased significantly after treatment with Curacron [1].
• Profenofos residues were quantified by using gas chromatography [7].
• 4-Bromo-2-chlorophenol (BCP), an aryl moiety of profenofos, was also determined in blood and urine with high performance liquid chromatograph (HPLC) as free or conjugated metabolites [17].

References