Chemical Compound Review:
Comtess (E)-2-cyano-3-(3,4-dihydroxy- 5-nitro...
Synonyms:
Entacom, Comtan, ENTACAPONE, Entacapona, Entacaponum, ...
- Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: effect of the plasma 3-O-methyldopa fraction on data analysis. Ishikawa, T., Dhawan, V., Chaly, T., Robeson, W., Belakhlef, A., Mandel, F., Dahl, R., Margouleff, C., Eidelberg, D. J. Cereb. Blood Flow Metab. (1996)
- Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. Kaakkola, S., Wurtman, R.J. J. Neurochem. (1993)
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- Cerebral 6-[18F]fluoro-L-DOPA uptake in rhesus monkey: pharmacological influence of aromatic amino acid decarboxylase (AAAD) and catechol-O-methyltransferase (COMT) inhibition. Psylla, M., Günther, I., Antonini, A., Vontobel, P., Reist, H.W., Zollinger, A., Leenders, K.L. Brain Res. (1997)
- The effect of entacapone (OR-611) on brain [18F]-6-L-fluorodopa metabolism: implications for levodopa therapy of Parkinson's disease. Sawle, G.V., Burn, D.J., Morrish, P.K., Lammertsma, A.A., Snow, B.J., Luthra, S., Osman, S., Brooks, D.J. Neurology (1994)
- Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. Merello, M., Lees, A.J., Webster, R., Bovingdon, M., Gordin, A. J. Neurol. Neurosurg. Psychiatr. (1994)
- L-dopa as substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase. Schultz, E. Biomed. Chromatogr. (1990)
- Acute toxicity of three new selective COMT inhibitors in mice with special emphasis on interactions with drugs increasing catecholaminergic neurotransmission. Törnwall, M., Männistö, P.T. Pharmacol. Toxicol. (1991)
- Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease. Cedarbaum, J.M., Leger, G., Guttman, M. Clinical neuropharmacology. (1991)
- Catechol-O-methyltransferase and aromatic L-amino acid decarboxylase activities in human gastrointestinal tissues. Schultz, E. Life Sci. (1991)