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Disease relevance of Scutellaria


High impact information on Scutellaria

  • Therefore, HLJDT and Scutellaria radix have an antiproliferative effect on myeloma cells, especially MPC-1- immature myeloma cells, and baicalein may be responsible for the suppressive effect of Scutellaria radix by blocking IkB-alpha degradation [5].
  • Scutellaria baicalensis inhibited COX-2 expression, whereas celecoxib inhibited COX-2 activity directly [6].
  • The IC(50)s were 150 micro g/ml for Scutellaria baicalensis, 25 micro M for celecoxib, and 75 micro M for baicalein and indomethacin [6].
  • The addition of TJ-9 to the cultures strongly induced IL-10, and this induction was mainly attributable to the effects of 2 components (scutellaria root and glycyrrhiza root) on the monocyte/macrophage fraction [7].
  • On the other hand, Phe-215 mutants of Scutellaria baicalensis CHS (L214I/F215L, F215W, F215Y, F215S, F215A, F215H, and F215C) afforded increased levels of truncated products; however, none of them generated benzalacetone [8].

Biological context of Scutellaria


Anatomical context of Scutellaria


Associations of Scutellaria with chemical compounds


Gene context of Scutellaria


Analytical, diagnostic and therapeutic context of Scutellaria


  1. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Zhao, Y., Li, H., Gao, Z., Gong, Y., Xu, H. Eur. J. Pharmacol. (2006) [Pubmed]
  2. Effect of processed Scutellaria baicalensis on dextran sulfate sodium-induced colitis in mice. Choi, Y.A., Kang, O.H., Park, H.J., Tae, J., Kim, D.K., Kang, C.S., Choi, S.C., Yun, K.J., Choi, S.J., Nah, Y.H., Kim, Y.H., Bae, K.H., Lee, Y.M. Int. J. Mol. Med. (2005) [Pubmed]
  3. Scutellaria flavonoid reduced memory dysfunction and neuronal injury caused by permanent global ischemia in rats. Shang, Y., Cheng, J., Qi, J., Miao, H. Pharmacol. Biochem. Behav. (2005) [Pubmed]
  4. In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. Nagai, T., Miyaichi, Y., Tomimori, T., Suzuki, Y., Yamada, H. Antiviral Res. (1992) [Pubmed]
  5. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Ma, Z., Otsuyama, K., Liu, S., Abroun, S., Ishikawa, H., Tsuyama, N., Obata, M., Li, F.J., Zheng, X., Maki, Y., Miyamoto, K., Kawano, M.M. Blood (2005) [Pubmed]
  6. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Zhang, D.Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., Li, X. Cancer Res. (2003) [Pubmed]
  7. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., Kosaka, Y. Hepatology (1997) [Pubmed]
  8. Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases. Abe, I., Sano, Y., Takahashi, Y., Noguchi, H. J. Biol. Chem. (2003) [Pubmed]
  9. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Huen, M.S., Leung, J.W., Ng, W., Lui, W.S., Chan, M.N., Wong, J.T., Xue, H. Biochem. Pharmacol. (2003) [Pubmed]
  10. Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Aung, H.H., Dey, L., Mehendale, S., Xie, J.T., Wu, J.A., Yuan, C.S. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  11. Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. Chan, J.Y., Tang, P.M., Hon, P.M., Au, S.W., Tsui, S.K., Waye, M.M., Kong, S.K., Mak, T.C., Fung, K.P. Planta Med. (2006) [Pubmed]
  12. Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. Wang, H., Hui, K.M., Chen, Y., Xu, S., Wong, J.T., Xue, H. Planta Med. (2002) [Pubmed]
  13. Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis. Lai, M.Y., Hsiu, S.L., Hou, Y.C., Tsai, S.Y., Chao, P.D. Planta Med. (2004) [Pubmed]
  14. Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. Chiu, J.H., Lay, I.S., Su, M.Y., Chiu, H.L., Chiu, A.C., Lui, W.Y., Wu, C.W. Planta Med. (2002) [Pubmed]
  15. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Chung, C.P., Park, J.B., Bae, K.H. Planta Med. (1995) [Pubmed]
  16. Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis. Kang, B.Y., Chung, S.W., Kim, S.H., Cho, D., Kim, T.S. Planta Med. (2003) [Pubmed]
  17. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., Okuda, H. Planta Med. (2001) [Pubmed]
  18. Endothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery. Chen, Z.Y., Su, Y.L., Lau, C.W., Law, W.I., Huang, Y. Eur. J. Pharmacol. (1999) [Pubmed]
  19. Molecular characterization of a novel beta-glucuronidase from Scutellaria baicalensis georgi. Sasaki, K., Taura, F., Shoyama, Y., Morimoto, S. J. Biol. Chem. (2000) [Pubmed]
  20. Novel hydrogen peroxide metabolism in suspension cells of Scutellaria baicalensis Georgi. Morimoto, S., Tateishi, N., Matsuda, T., Tanaka, H., Taura, F., Furuya, N., Matsuyama, N., Shoyama, Y. J. Biol. Chem. (1998) [Pubmed]
  21. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Chang, Y.L., Shen, J.J., Wung, B.S., Cheng, J.J., Wang, D.L. Mol. Pharmacol. (2001) [Pubmed]
  22. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Chi, Y.S., Kim, H.P. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  23. Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts. Nakajima, T., Imanishi, M., Yamamoto, K., Cyong, J.C., Hirai, K. Planta Med. (2001) [Pubmed]
  24. Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. Chuang, H.N., Wang, J.Y., Chiu, J.H., Tsai, T.H., Yeh, S.F., Fu, S.L., Lui, W.Y., Wu, C.W. Planta Med. (2005) [Pubmed]
  25. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Kim, B.R., Kim, D.H., Park, R., Kwon, K.B., Ryu, D.G., Kim, Y.C., Kim, N.Y., Jeong, S., Kang, B.K., Kim, K.S. Planta Med. (2001) [Pubmed]
  26. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., Zhang, D. Cancer Lett. (2004) [Pubmed]
  27. Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Tsai, P.L., Tsai, T.H. Planta Med. (2004) [Pubmed]
  28. Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts. Chen, X., Nishida, H., Konishi, T. Biol. Pharm. Bull. (2003) [Pubmed]
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