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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Arborinin     1-hydroxy-2,3-dimethoxy-10- methyl-acridin...

Synonyms: Arbornine, Arborinine, CHEMBL349609, SureCN1663913, NSC-94650, ...
 
 
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High impact information on Arborinin

  • Investigation of Cytotoxic Activity on Human Cancer Cell Lines of Arborinine and Furanoacridones Isolated from Ruta graveolens [1].
  • Antispasmogenic effect of rutamarin and arborinine on isolated smooth muscle organs [2].
  • Different effects of arborinine alkaloid obtained from Brazilian Erthela baihensis on spleen and thymus cells stimulated in vitro with different mitogens [3].
  • Our results showed an inhibitory effect of arborinine on splenocytes proliferation under ConA or PWM stimulation and increased apoptosis on splenocytes and thymocytes stimulated with PWM in 24 hr [3].
  • The present study has examined the effects of arborinine, an alkaloid obtained from Erthela bahiensis, a Brazilian plant popularly used as diuretic, antidiabetic, antithermic and expectorant, on the viability and function of immune system cells in vitro using a murine model [3].
 

Anatomical context of Arborinin

 

Associations of Arborinin with other chemical compounds

  • (Rutaceae) and of two further acridone alkaloids (arborinine and evoxanthine) were investigated by means of the MTT assay, using the human cell lines HeLa, MCF7 and A431 [1].
  • Seven alkaloids have been isolated from Teclea trichocarpa including four, normelicopicine (1), arborinine (2), skimmianine (6), and dictamnine (7), that are reported for the first time in addition to the previously reported alkaloids melicopicine (3), tecleanthine (4), and 6-methoxytecleanthine (5) [4].

References

  1. Investigation of Cytotoxic Activity on Human Cancer Cell Lines of Arborinine and Furanoacridones Isolated from Ruta graveolens. Réthy, B., Zupkó, I., Minorics, R., Hohmann, J., Ocsovszki, I., Falkay, G. Planta Med. (2007) [Pubmed]
  2. Antispasmogenic effect of rutamarin and arborinine on isolated smooth muscle organs. Minker, E., Bartha, C., Rózsa, Z., Szendrei, K., Reisch, J. Planta Med. (1979) [Pubmed]
  3. Different effects of arborinine alkaloid obtained from Brazilian Erthela baihensis on spleen and thymus cells stimulated in vitro with different mitogens. Roseghini, R., Moreira, P., Vale, V., Pinheiro, A.M., Costa, J.F., Bittencourt, T., Nascimento, I., Schaer, R., Velozo, E., El-Bachá, R., Meyer, R., Freire, S. Immunopharmacology and immunotoxicology. (2006) [Pubmed]
  4. Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine. Muriithi, M.W., Abraham, W.R., Addae-Kyereme, J., Scowen, I., Croft, S.L., Gitu, P.M., Kendrick, H., Njagi, E.N., Wright, C.W. J. Nat. Prod. (2002) [Pubmed]
 
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