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Chemical Compound Review:

CHEBI:63989 (5Z,8Z,11Z,13E,15R)-15- hydroxyicosa-5,8,11...

Synonyms: CHEBI:104378, LMFA03060030, AC1NR1OH, 15R-HETE

Schneider, C. et al., Fiorucci, S. et al., Gronert, K. et al.

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High impact information on LMFA03060030

In addition, aspirin-treated enterocytes generated 15R-HETE, a precursor of 15-epi-LXA4 biosynthesis, whose potent bioactions were mimicked by the stable analog 15R/S-methyl-LXA4 [1].
Remarkably, aspirin-treated COX-2 formed 15R-HETE with removal of the pro-S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the formation of prostaglandins by native cyclooxygenase [2].
The acetylated COX-2 remains active, and upon cell activation, initiates the generation of 15R-HETE, a lipid substrate for 5-lipoxygenase (LOX) leading to the formation of 15-epi-LXA4 (also termed "aspirin-triggered lipoxin," or ATL) [3].

Biological context of LMFA03060030

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site [2].

Gene context of LMFA03060030

To understand the changes that lead to 15R-HETE synthesis in aspirin-treated COX-2, we employed pro-R- and pro-S-labeled [13-(3)H]arachidonic acids to investigate the selectivity of the initial hydrogen abstraction [2].

References

Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. Gronert, K., Gewirtz, A., Madara, J.L., Serhan, C.N. J. Exp. Med. (1998) [Pubmed]
Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site. Schneider, C., Brash, A.R. J. Biol. Chem. (2000) [Pubmed]
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. Fiorucci, S., Distrutti, E., de Lima, O.M., Romano, M., Mencarelli, A., Barbanti, M., Palazzini, E., Morelli, A., Wallace, J.L. FASEB J. (2003) [Pubmed]

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