Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NR9O8 ethane; ethanol; methanol; methoxymethane

Synonyms:

Vladkova, T. et al., Park, J.H. et al., Ciper, M. et al., Goldsmith, E.J. et al., Giancotti, F.R. et al., et al.

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Disease relevance of POLYETHYLENE GLYCOL (N=34)

B16 mouse melanoma cells in monolayers may be satisfactorily fused with 50% PEG 1500 [1].

High impact information on POLYETHYLENE GLYCOL (N=34)

Crystals of bacterially expressed plasminogen activator inhibitor (PAI-1) suitable for X-ray diffraction analysis have been obtained from 8% (w/v) PEG 1500, pH 8.25 [2].
The addition of the hydrophilic additives (xylitol, sorbitol or PEG 1500) did not significantly affect the viscosity and gelation temperature of the dipping solution [3].
In contrast, PEG 1500 had to be considered is 'the worst' material, because of lower initial cell adhesion and spreading and FN pre-adsorption did not restore normal cell morphology [4].
Splenic lymphocytes from the immunized mouse were fused with the myeloma cells SP2/0-AG14 in the presence of PEG 1500 [5].
Fluorescence labelling of ex vivo isolated macrophages prior to fusion and subsequent FACS analysis showed that PEG-4000 is a more effective fusion agent than PEG-1500 [6].

References

Surfactant enhancement of polyethyleneglycol-induced cell fusion. Prado, A., Partearroyo, M.A., Mencía, M., Goñi, F.M., Barberá-Guillem, E. FEBS Lett. (1989) [Pubmed]
Preliminary X-ray analysis of crystals of plasminogen activator inhibitor-1. Goldsmith, E.J., Sheng-Cheng, C., Danley, D.E., Gerard, R.D., Geoghegan, K.F., Mottonen, J., Strand, A. Proteins (1991) [Pubmed]
Preparation and characterization of novel fast disintegrating capsules (Fastcaps) for administration in the oral cavity. Ciper, M., Bodmeier, R. International journal of pharmaceutics. (2005) [Pubmed]
Preparation of PEG-coated surfaces and a study for their interaction with living cells. Vladkova, T., Krasteva, N., Kostadinova, A., Altankov, G. Journal of biomaterials science. Polymer edition. (1999) [Pubmed]
Immunohistochemical characterization of a monoclonal antibody detecting an endometrioid ovarian cancer-associated antigen. Giancotti, F.R., Dorsett, B.H., Kim, K.T., Ioachim, H.L., Barber, H.R. Int. J. Gynecol. Pathol. (1990) [Pubmed]
Generation and characterization of a novel fusion partner cell line for the production of human macrophage hybridoma. Park, J.H., Cho, E.W., Lee, Y.J., Hahm, K.S., Kim, K.L. Hybridoma (1997) [Pubmed]

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