Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NSJS5 (2S,3S,4R)-4- benzo[1,3]dioxol-5-yl-1...

Synonyms: CHEMBL428504, SureCN7069251, CHEBI:105158, A127722

Blezer, E.L. et al., Nelson, J.B. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of A127722

However, A127722 treatment did not prolong survival in SHRSP with cerebral edema [1].
Late-onset A127722 treatment failed to affect survival, systolic blood pressure, or proteinuria [1].
Development of hypertension, cerebral edema, and proteinuria was prevented in SHRSP when A127722 treatment was initiated at the start of salt-loading [1].

High impact information on A127722

-The ability of endothelin receptor blockade to prevent and to treat established cerebral and renal injury was explored in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP) with the endothelin receptor subtype-A antagonist A127722 [1].
Conversely, areas of new bone formation were significantly less in animals treated with a selective endothelin A (ET(A)) receptor antagonist A127722 [2].

References

Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats. Blezer, E.L., Nicolay, K., Goldschmeding, R., Jansen, G.H., Koomans, H.A., Rabelink, T.J., Joles, J.A. Hypertension (1999) [Pubmed]
New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade. Nelson, J.B., Nguyen, S.H., Wu-Wong, J.R., Opgenorth, T.J., Dixon, D.B., Chung, L.W., Inoue, N. Urology (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share