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Chemical Compound Review:

SureCN2030327 N-[(4- dimethylaminophenyl)methyl]- 7...

Synonyms: AC1NSK18, KB-56923, CTK8E8940, FT-0693687, W-54011, ...

This record was replaced with 5311122.

Sumichika, H. et al.

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Disease relevance of N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

In gerbils, oral administration of W-54011 (3-30 mg/kg) inhibited C5a-induced neutropenia in a dose-dependent manner [1].

High impact information on N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

W-54011 inhibited the binding of (125)I-labeled C5a to human neutrophils with a K(i) value of 2.2 nm [1].

Biological context of N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

Examination on the species specificity of W-54011 revealed that it was able to inhibit C5a-induced intracellular Ca(2+) mobilization in neutrophils of cynomolgus monkeys and gerbils but not mice, rats, guinea pigs, rabbits, and dogs [1].

References

Identification of a potent and orally active non-peptide C5a receptor antagonist. Sumichika, H., Sakata, K., Sato, N., Takeshita, S., Ishibuchi, S., Nakamura, M., Kamahori, T., Ehara, S., Itoh, K., Ohtsuka, T., Ohbora, T., Mishina, T., Komatsu, H., Naka, Y. J. Biol. Chem. (2002) [Pubmed]

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